Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPINT1
  • Mouse genes Spint1
  • Rat genes Spint1
  • Zfish genes spint1a,spint1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spint1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	spint1a	IMP	ZFIN:ZDB-GENO-071219-4	Zfish	PMID:29301867
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Spint1	IMP		Rat	PMID:18048349|RGD:10043098
Cellular Component	GO:0070062	extracellular exosome	SPINT1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	SPINT1	HDA		Human	PMID:16502470
Cellular Component	GO:0005886	plasma membrane	Spint1	IDA		Mouse	PMID:25758223
Cellular Component	GO:0005886	plasma membrane	Spint1	IDA		Rat	PMID:23409135|RGD:10043095
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	Spint1	IMP	MGI:MGI:3709554	Mouse	PMID:17174946
Biological Process	GO:0008283	cell population proliferation	spint1a	IMP	ZFIN:ZDB-GENO-200109-5	Zfish	PMID:29301867
Biological Process	GO:0008283	cell population proliferation	spint1a	IGI	ZFIN:ZDB-GENE-040426-2169	Zfish	PMID:29301867
Biological Process	GO:0071773	cellular response to BMP stimulus	Spint1	IEP		Rat	PMID:23409135|RGD:10043095
Biological Process	GO:0030199	collagen fibril organization	spint1a	IGI	ZFIN:ZDB-GENE-040426-2132	Zfish	PMID:26015541
Biological Process	GO:0001892	embryonic placenta development	Spint1	IMP	MGI:MGI:3581891	Mouse	PMID:15964823
Biological Process	GO:0008544	epidermis development	spint1a	IMP	ZFIN:ZDB-GENO-071219-4	Zfish	PMID:17728346
Biological Process	GO:0008544	epidermis development	spint1a	IGI	ZFIN:ZDB-GENO-071219-4,ZFIN:ZDB-MRPHLNO-080227-2	Zfish	PMID:17881499
Biological Process	GO:0008544	epidermis development	spint1a	IMP	ZFIN:ZDB-GENO-071219-4	Zfish	PMID:17881499
Biological Process	GO:0008544	epidermis development	spint1b	IGI	ZFIN:ZDB-MRPHLNO-071218-4,ZFIN:ZDB-MRPHLNO-071218-5	Zfish	PMID:17728346
Biological Process	GO:0060429	epithelium development	spint1a	IGI	ZFIN:ZDB-GENE-040426-2132	Zfish	PMID:26015541
Biological Process	GO:0030198	extracellular matrix organization	Spint1	IMP	MGI:MGI:3709554	Mouse	PMID:17174946
Biological Process	GO:0002009	morphogenesis of an epithelium	spint1a	IMP	ZFIN:ZDB-GENO-200109-5	Zfish	PMID:29301867
Biological Process	GO:0002009	morphogenesis of an epithelium	spint1a	IGI	ZFIN:ZDB-GENE-040426-2169	Zfish	PMID:29301867
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Spint1	IMP		Rat	PMID:23409135|RGD:10043095
Biological Process	GO:0001843	neural tube closure	Spint1	IGI	MGI:MGI:1338881	Mouse	PMID:19592578
Biological Process	GO:0001843	neural tube closure	Spint1	IGI	MGI:MGI:1338031	Mouse	PMID:19592578
Biological Process	GO:0030593	neutrophil chemotaxis	spint1a	IMP	ZFIN:ZDB-GENO-071219-4	Zfish	PMID:17881499
Biological Process	GO:0060674	placenta blood vessel development	Spint1	IMP	MGI:MGI:3709554	Mouse	PMID:17174946
Biological Process	GO:0045687	positive regulation of glial cell differentiation	Spint1	IMP		Rat	PMID:23409135|RGD:10043095
Biological Process	GO:0050727	regulation of inflammatory response	spint1a	IMP	ZFIN:ZDB-GENO-201008-2	Zfish	PMID:31519199

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern