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Spint1
Gene Detail
 Symbol
Name
ID
Spint1
serine protease inhibitor, Kunitz type 1
MGI:1338033
Synonyms HAI-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
59.97 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:119237362-119249527 bp, + strand
From VEGA annotation of GRCm38

  12166 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9653  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Spint1

Human
homologs
Human Homolog SPINT1, serine peptidase inhibitor, Kunitz type 1
NCBI Gene ID 6692
neXtProt AC  NX_O43278
Human Synonyms  HAI, HAI1, MANSC2
Human Chr (Location)  15q15.1; chr15:40844048-40857655 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit embryonic lethality at E10.5 or earlier, growth retardation, and widespread cell apoptosis. Placental development is impaired with abnormalities in branching morphogenesis, the formation of the labyrinth layer and placental function.
 
Interactions
Spint1 interacts with 117 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process branching involved in labyrinthine layer morphogenesis, embryonic placenta development, ...
Component extracellular region, extracellular space, ...
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (51)    Tissues (47)    Images (2)
Theiler Stages: 12, 15, 23, 28
Assay TypeResults
RNA in situ 4
RT-PCR 47
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(75) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015880 (Evidence)
Ensembl Gene ModelENSMUSG00000027315 (Evidence)
Entrez Gene20732 (Evidence)
UniGene104955
DFCITC1576725, TC1580779, TC1598286
DoTSDT.60118553, DT.91341837, DT.94162178
NIA Mouse Gene IndexU002308
Consensus CDS ProjectCCDS16597.1
International Mouse Knockout Project StatusSpint1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015880 VEGA Gene Model | MGI Sequence Detail 12166 C57BL/6J ±  kb
transcript OTTMUST00000037745 VEGA | MGI Sequence Detail 2273 Not Applicable 
polypeptide OTTMUSP00000016930 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
InterPro IPR013980 Seven cysteines
InterPro IPR011106 Seven cysteines, N-terminal
Protein Ontology PR:000015542 kunitz-type protease inhibitor 1
References (Earliest) J:53204 Itoh H, et al., Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human. Biochem Biophys Res Commun. 1999 Feb 24;255(3):740-8
(Latest) J:198274 Mikelis CM, et al., PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem. 2013 Apr 26;288(17):12232-43
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory