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Spint1
Gene Detail
Symbol

Name
ID
Spint1
serine protease inhibitor, Kunitz type 1
MGI:1338033
Synonyms
HAI-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.97 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:119237362-119249527 bp, + strand
From VEGA annotation of GRCm38

  12166 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9653  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SPINT1
Gene Tree: Spint1

Human
homologs
SPINT1, serine peptidase inhibitor, Kunitz type 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6692
neXtProt AC: NX_O43278

Human Synonyms: HAI, HAI1, MANSC2

Human Chr (Location): 15q15.1; chr15:40844018-40857655 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit embryonic lethality at E10.5 or earlier, growth retardation, and widespread cell apoptosis. Placental development is impaired with abnormalities in branching morphogenesis, the formation of the labyrinth layer and placental function.
 
Interactions
Spint1 interacts with 117 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (51)    Tissues (47)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 47
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SPINT1 ; Xenbase spint1 ; ZFIN spint1b    NEW 
Molecular
reagents
All nucleic(78) cDNA(75) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015880 (Evidence)
Ensembl Gene Model ENSMUSG00000027315 (Evidence)
Entrez Gene 20732 (Evidence)
UniGene 104955
DFCI TC1576725, TC1580779, TC1598286
DoTS DT.60118553, DT.91341837, DT.94162178
NIA Mouse Gene Index U002308
Consensus CDS Project CCDS16597.1
International Mouse Phenotyping Consortium Status Spint1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015880 VEGA Gene Model | MGI Sequence Detail 12166 C57BL/6J ±  kb
transcript OTTMUST00000037745 VEGA | MGI Sequence Detail 2273 Not Applicable 
polypeptide OTTMUSP00000016930 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR013980 MANSC domain
InterPro IPR002223 Pancreatic trypsin inhibitor Kunitz domain
InterPro IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
InterPro IPR011106 Seven cysteines, N-terminal
Protein Ontology PR:000015542 kunitz-type protease inhibitor 1
References
(Earliest) J:53204 Itoh H, et al., Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human. Biochem Biophys Res Commun. 1999 Feb 24;255(3):740-8
(Latest) J:221185 Kawaguchi M, et al., Hepatocyte Growth Factor Activator Inhibitor Type 1 Maintains the Assembly of Keratin into Desmosomes in Keratinocytes by Regulating Protease-Activated Receptor 2-Dependent p38 Signaling. Am J Pathol. 2015 Jun;185(6):1610-23
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory