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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Spint1
serine protease inhibitor, Kunitz type 1
MGI:1338033
30 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
involves: 129S5/SvEvBrd
abnormal basement membrane morphology J:118798
abnormal placenta labyrinth morphology J:118798
abnormal placental labyrinth vasculature morphology J:118798
abnormal trophoblast layer morphology J:118798
normal embryo phenotype J:118798
embryonic lethality during organogenesis, complete penetrance J:118798
Spint1tm1b(EUCOMM)Wtsi/Spint1+
C57BL/6N-Spint1tm1b(EUCOMM)Wtsi/Tcp
preweaning lethality, incomplete penetrance J:211773
Spint1tm1b(EUCOMM)Wtsi/Spint1tm1b(EUCOMM)Wtsi
C57BL/6N-Spint1tm1b(EUCOMM)Wtsi/Tcp
preweaning lethality, complete penetrance J:211773
Spint1tm1Bug/Spint1tm1Bug
involves: 129S6/SvEvTac
absent placental labyrinth J:188121
embryonic lethality during organogenesis, complete penetrance J:188121
Spint1tm1Bug/Spint1tm1Bug
involves: 129S6/SvEvTac * NIH Black Swiss
abnormal trophoblast layer morphology J:142708
absent placental labyrinth J:142708
embryonic growth retardation J:142708
embryonic lethality during organogenesis, complete penetrance J:142708
Spint1tm1Hk/Spint1tm1Hk
involves: C57BL/6 * CBA
abnormal chorionic plate morphology J:99182
abnormal placenta development J:99182
abnormal placenta morphology J:99182
abnormal placenta vasculature J:99182
abnormal placental transport J:99182
abnormal trophoblast giant cell morphology J:99182
absent placental labyrinth J:99182
embryonic growth arrest J:99182
embryonic lethality during organogenesis, complete penetrance J:99182
enlarged pericardium J:99182
increased embryonic tissue cell apoptosis J:99182
Spint1tm2.1Hk/Spint1tm2.1Hk
Tg(Vil1-cre)997Gum/0
involves: C57BL/6 * C57BL/6J * SJL
abnormal defecation J:179937
abnormal enterocyte proliferation J:179937
abnormal intestine physiology J:179937
abnormal large intestine crypts of Lieberkuhn morphology J:179937
diarrhea J:179937
increased enterocyte apoptosis J:179937
increased susceptibility to induced colitis J:179937
increased susceptibility to weight loss J:179937
increased susceptibility to xenobiotic induced morbidity/mortality J:179937
intestinal ulcer J:179937
small cecum J:179937

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory