Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC22A6
  • Mouse genes Slc22a6
  • Rat genes Slc22a6
  • Zfish genes slc22a6l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc22a6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015297	antiporter activity	Slc22a6	IDA		Rat	PMID:18361503|RGD:7243886
Molecular Function	GO:0031404	chloride ion binding	Slc22a6	IDA		Rat	PMID:18361503|RGD:7243886
Molecular Function	GO:0042802	identical protein binding	Slc22a6	IPI	RGD:69338	Rat	PMID:18361503|RGD:7243886
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	SLC22A6	IDA		Human	PMID:10049739
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	SLC22A6	IDA		Human	PMID:11907186
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	SLC22A6	IDA		Human	PMID:16024787
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	SLC22A6	IMP		Human	PMID:22169006
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	SLC22A6	IDA		Human	PMID:9950961
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	Slc22a6	IMP		Mouse	MGI:MGI:5314493|PMID:22169006
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	Slc22a6	IDA		Mouse	PMID:10751225
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	Slc22a6	IDA		Rat	PMID:15068970|RGD:1304320
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	slc22a6l	IDA		Zfish	PMID:31255699
Molecular Function	GO:0015132	prostaglandin transmembrane transporter activity	SLC22A6	IDA		Human	PMID:11907186
Molecular Function	GO:0005515	protein binding	SLC22A6	IPI	UniProtKB:Q92624	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SLC22A6	IPI	UniProtKB:Q92624	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	Slc22a6	IPI	RGD:620348	Rat	PMID:16000875|RGD:2300100
Molecular Function	GO:0015347	sodium-independent organic anion transmembrane transporter activity	Slc22a6	IDA		Rat	PMID:9228014|RGD:68822
Molecular Function	GO:0005452	solute:inorganic anion antiporter activity	SLC22A6	IDA		Human	PMID:15037815
Cellular Component	GO:0009925	basal plasma membrane	SLC22A6	IDA		Human	PMID:35307651
Cellular Component	GO:0016323	basolateral plasma membrane	SLC22A6	IDA		Human	PMID:15037815
Cellular Component	GO:0016323	basolateral plasma membrane	SLC22A6	IDA		Human	PMID:9887087
Cellular Component	GO:0016323	basolateral plasma membrane	SLC22A6	IDA		Human	PMID:27053689
Cellular Component	GO:0005901	caveola	Slc22a6	IDA		Rat	PMID:16000875|RGD:2300100
Cellular Component	GO:0070062	extracellular exosome	SLC22A6	HDA		Human	PMID:19056867
Cellular Component	GO:0005886	plasma membrane	SLC22A6	IDA		Human	PMID:14749323
Cellular Component	GO:0005886	plasma membrane	Slc22a6	IDA		Mouse	MGI:MGI:5315700|PMID:14749323
Cellular Component	GO:0005886	plasma membrane	Slc22a6	IDA		Rat	PMID:16000875|RGD:2300100
Cellular Component	GO:0005886	plasma membrane	slc22a6l	IDA		Zfish	PMID:31255699
Cellular Component	GO:0032991	protein-containing complex	Slc22a6	IDA		Rat	PMID:16000875|RGD:2300100
Biological Process	GO:0015742	alpha-ketoglutarate transport	SLC22A6	IDA		Human	PMID:9950961
Biological Process	GO:0072237	metanephric proximal tubule development	Slc22a6	IEP		Rat	PMID:30645697|RGD:155631307
Biological Process	GO:0006820	monoatomic anion transport	Slc22a6	IDA		Mouse	PMID:10751225
Biological Process	GO:0015711	organic anion transport	SLC22A6	IDA		Human	PMID:10049739
Biological Process	GO:0015711	organic anion transport	SLC22A6	IMP		Human	PMID:22169006
Biological Process	GO:0015711	organic anion transport	SLC22A6	IDA		Human	PMID:9950961
Biological Process	GO:0015711	organic anion transport	Slc22a6	IMP		Mouse	MGI:MGI:5314493|PMID:22169006
Biological Process	GO:0015711	organic anion transport	Slc22a6	IDA		Rat	PMID:15068970|RGD:1304320
Biological Process	GO:0015732	prostaglandin transport	SLC22A6	IDA		Human	PMID:11907186
Biological Process	GO:0097254	renal tubular secretion	SLC22A6	IMP		Human	PMID:22169006
Biological Process	GO:0097254	renal tubular secretion	Slc22a6	IMP		Mouse	MGI:MGI:5314493|PMID:22169006
Biological Process	GO:0014070	response to organic cyclic compound	Slc22a6	IEP		Rat	PMID:16925582|RGD:1598604
Biological Process	GO:0043252	sodium-independent organic anion transport	Slc22a6	IDA		Rat	PMID:9228014|RGD:68822

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern