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Slc22a6 Gene Detail
Summary
  • Symbol
    Slc22a6
  • Name
    solute carrier family 22 (organic anion transporter), member 6
  • Synonyms
    mOat1, NKT, Oat1, Orctl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:892001
    NCBI Gene: 18399
  • Gene Overview
    MyGene.info: SLC22A6
Location & Maps
more
  • Sequence Map
    Chr19:8617996-8628299 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10304 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    SLC22A6, solute carrier family 22 member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC22A6, solute carrier family 22 member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOAT1, OAT1, PAHT, ROAT1
  • Links
    NCBI Gene ID: 9356
    neXtProt AC: NX_Q4U2R8

  • Chr Location
    11q12.3; chr11:62976597-62985023 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18399 NCBI Gene Model | MGI Sequence Detail 10304 C57BL/6J ±  kb
transcript NM_008766 RefSeq | MGI Sequence Detail 4026 C57BL/6  
polypeptide Q8VC69 UniProt | EBI | MGI Sequence Detail 545 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    118 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014993 solute carrier family 22 member 6
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR004749 Organic cation transport protein/SVOP
Molecular
Reagents
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  • All nucleic 96
    cDNA 91
    Primer pair 5

    Microarray probesets 4
References
more
  • Summaries
    All 54
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:38984 Lopez-Nieto CE, et al., Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem. 1997 Mar 7;272(10):6471-8
  • Latest
    J:201751 Wang L, et al., The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination. Biochem Pharmacol. 2013 Oct 1;86(7):991-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory