Slc22a6
Gene Detail

Symbol Name ID

Slc22a6 solute carrier family 22 (organic anion transporter), member 6 MGI:892001

Synonyms

mOat1, NKT, Oat1, Orctl1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr19:8617996-8628299 bp, + strand From NCBI annotation of GRCm38   10304 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc22a6 ± 2 cM)

Gene Tree: Slc22a6

Human ortholog

SLC22A6 solute carrier family 22 (organic anion transporter), member 6 NCBI Gene ID 9356
Human Synonyms: HOAT1, OAT1, PAHT, ROAT1
Human Chr11:62744069-62752469 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	alpha-ketoglutarate transport, anion transport, ...
Component	basolateral plasma membrane, caveola, ...
Function	inorganic anion exchanger activity, ion transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (386)    Tissues (198)    Images (41)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	240
In situ reporter (knock in)	60
RT-PCR	86

cDNA source data(90)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(96) cDNA(91) Primer pair(5)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024650 (Evidence)
Entrez Gene	18399 (Evidence)
UniGene	30090
DFCI	TC1577678, TC1589195
DoTS	DT.486400
NIA Mouse Gene Index	U019118
Consensus CDS Project	CCDS29538.1
International Mouse Knockout Project Status	Slc22a6

Sequences

Length	Strain/Species
genomic	18399	NCBI Gene Model | MGI Sequence Detail	10304	C57BL/6J
transcript	NM_008766	RefSeq | MGI Sequence Detail	4026	C57BL/6
polypeptide	Q8VC69	UniProt | EBI | MGI Sequence Detail	545	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR004749	Organic cation transport protein
Protein Ontology	PR:000014993	solute carrier family 22 member 6

Graphical View of Protein Domain Structure

References

(Earliest) J:38984 Lopez-Nieto CE, et al., Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem. 1997 Mar 7;272(10):6471-8
(Latest) J:184733 Vallon V, et al., A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012 May;302(10):F1293-9
All references(56)