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Slc22a6
Gene Detail
Symbol

Name
ID
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
MGI:892001
Synonyms
mOat1, NKT, Oat1, Orctl1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:8617996-8628299 bp, + strand
From NCBI annotation of GRCm38

  10304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16813  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 western clawed frog; 1 zebrafish

Gene Tree: Slc22a6

Human
homologs
Human Homolog SLC22A6, solute carrier family 22 (organic anion transporter), member 6
NCBI Gene ID 9356
neXtProt AC  NX_Q4U2R8
Human Synonyms  HOAT1, OAT1, PAHT, ROAT1
Human Chr (Location)  11q12.3; chr11:62976597-62985023 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions.
 
Interactions
Slc22a6 interacts with 282 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process alpha-ketoglutarate transport, anion transport, ...
Component basolateral plasma membrane, caveola, ...
Function anion:anion antiporter activity, chloride ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (411)    Tissues (214)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 265
In situ reporter (knock in) 60
RT-PCR 86
cDNA source data(90)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(91) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024650 (Evidence)
Entrez Gene18399 (Evidence)
UniGene30090
DFCITC1589195, TC1577678
DoTSDT.486400
NIA Mouse Gene IndexU019118
Consensus CDS ProjectCCDS29538.1
International Mouse Knockout Project StatusSlc22a6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18399 NCBI Gene Model | MGI Sequence Detail 10304 C57BL/6J ±  kb
transcript NM_008766 RefSeq | MGI Sequence Detail 4026 C57BL/6 
polypeptide Q8VC69 UniProt | EBI | MGI Sequence Detail 545 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004749 Organic cation transport protein
Protein Ontology PR:000014993 solute carrier family 22 member 6
Graphical View of Protein Domain Structure
References
(Earliest) J:38984 Lopez-Nieto CE, et al., Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem. 1997 Mar 7;272(10):6471-8
(Latest) J:201751 Wang L, et al., The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination. Biochem Pharmacol. 2013 Oct 1;86(7):991-6
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory