Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC18A1
  • Mouse genes Slc18a1
  • Rat genes Slc18a1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc18a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Slc18a1	IPI	RGD:3853	Rat	PMID:19903816|RGD:5128868
Molecular Function	GO:0015311	monoamine:proton antiporter activity	SLC18A1	IDA		Human	PMID:8643547
Molecular Function	GO:0015311	monoamine:proton antiporter activity	Slc18a1	IDA		Mouse	MGI:MGI:7413162|PMID:21712771
Molecular Function	GO:0015311	monoamine:proton antiporter activity	Slc18a1	IDA		Rat	PMID:8125935|RGD:155663520
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc18a1	IDA		Rat	PMID:16926160|RGD:5130998
Cellular Component	GO:0005737	cytoplasm	Slc18a1	IDA		Rat	PMID:16926160|RGD:5130998
Cellular Component	GO:0045202	synapse	Slc18a1	IDA		Mouse	PMID:23201251
Biological Process	GO:0071285	cellular response to lithium ion	Slc18a1	IEP		Rat	PMID:11080216|RGD:5131196
Biological Process	GO:0051612	negative regulation of serotonin uptake	Slc18a1	IMP		Rat	PMID:16926160|RGD:5130998
Biological Process	GO:0033603	positive regulation of dopamine secretion	Slc18a1	IMP		Rat	PMID:17244889|RGD:5131195
Biological Process	GO:0051610	serotonin uptake	SLC18A1	IDA		Human	PMID:8643547
Biological Process	GO:0051610	serotonin uptake	Slc18a1	IDA		Mouse	MGI:MGI:7413162|PMID:21712771
Biological Process	GO:0051610	serotonin uptake	Slc18a1	IDA		Rat	PMID:19008227|RGD:5131091
Biological Process	GO:0051610	serotonin uptake	Slc18a1	IDA		Rat	PMID:8125935|RGD:155663520

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern