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Slc18a1 Gene Detail
Summary
  • Symbol
    Slc18a1
  • Name
    solute carrier family 18 (vesicular monoamine), member 1
  • Synonyms
    4832416I10Rik, MGC:28683, MGC:37299
  • Feature Type
    protein coding gene
  • IDs
    MGI:106684
    NCBI Gene: 110877
Location & Maps
more
  • Sequence Map
    Chr8:69037711-69089235 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51525 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.88 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLC18A1, solute carrier family 18 member A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC18A1, solute carrier family 18 member A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGAT, VAT1, VMAT1
  • Links
    NCBI Gene ID: 6570
    neXtProt AC: NX_P54219

  • Chr Location
    8p21.3; chr8:20144855-20183338 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Slc18a1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased neuron apoptosis, decreased neuron proliferation and impaired spatial object recognition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025652 VEGA Gene Model | MGI Sequence Detail 51525 C57BL/6J ±  kb
transcript OTTMUST00000063128 VEGA | MGI Sequence Detail 3115 Not Applicable  
polypeptide OTTMUSP00000031186 VEGA | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    379 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014966 chromaffin granule amine transporter
  • InterPro Domains
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
    IPR004734 Multidrug resistance protein
Molecular
Reagents
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  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35143, MGI:2443911
References
more
  • Summaries
    All 42
    Developmental Gene Expression 14
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:16163 Peter D, et al., Chromosomal localization of the human vesicular amine transporter genes. Genomics. 1993 Dec;18(3):720-3
  • Latest
    J:199593 Huber K, et al., The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells. Dev Biol. 2013 Aug 15;380(2):286-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory