Slc18a1
Gene Detail

Symbol Name ID

Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 MGI:106684

Synonyms

4832416I10Rik, MGC:28683, MGC:37299

Feature Type

protein coding gene

Genetic Map

Chromosome 8

33.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:69037711-69089235 bp, - strand From VEGA annotation of GRCm38   51525 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc18a1 ± 2 cM)

Protein SuperFamily: synaptic vesicle amine transporter
Gene Tree: Slc18a1

Human ortholog

SLC18A1 solute carrier family 18 (vesicular monoamine), member 1 NCBI Gene ID 6570
Human Synonyms: CGAT, VAT1, VMAT1
Human Chr8:20002366-20040717 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	drug transport, negative regulation of serotonin uptake, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	drug transmembrane transporter activity, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (219)    Tissues (174)    Images (21)
Theiler Stages: 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	138
In situ reporter (knock in)	37
Western blot	4
RT-PCR	38

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000025652 (Evidence)
Ensembl Gene Model	ENSMUSG00000036330 (Evidence)
Entrez Gene	110877 (Evidence)
UniGene	19301
DFCI	TC1582543, TC1592997, TC1634648
DoTS	DT.102555411, DT.55131432, DT.94236305
NIA Mouse Gene Index	U029894
Consensus CDS Project	CCDS22344.1
International Mouse Knockout Project Status	Slc18a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025652	VEGA Gene Model | MGI Sequence Detail	51525	C57BL/6J
transcript	OTTMUST00000063128	VEGA | MGI Sequence Detail	3115	Not Applicable
polypeptide	OTTMUSP00000031186	VEGA | MGI Sequence Detail	521	Not Applicable

All sequences(38) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(293 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR004734	Multidrug resistance protein
Protein Ontology	PR:000014966	chromaffin granule amine transporter

References

(Earliest) J:16163 Peter D, et al., Chromosomal localization of the human vesicular amine transporter genes. Genomics. 1993 Dec;18(3):720-3
(Latest) J:176226 Yan CH, et al., Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. J Neurosci. 2011 Aug 31;31(35):12413-25
All references(42)

Other accession IDs

MGD-MRK-35143, MGI:2443911