Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SERPINA12
  • Mouse genes Serpina12
  • Rat genes Serpina12
  • Zfish genes serpina7,si:ch211-186e20.7,zgc:113828,zgc:174259,zgc:174260
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpina12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140678	molecular function inhibitor activity	SERPINA12	IMP		Human	PMID:23370777
Molecular Function	GO:0005515	protein binding	Serpina12	IPI	PR:P20029	Mouse	PMID:22837305
Cellular Component	GO:0005615	extracellular space	Serpina12	IDA		Mouse	PMID:22837305
Cellular Component	GO:0005886	plasma membrane	Serpina12	IDA		Mouse	PMID:22837305
Biological Process	GO:0006094	gluconeogenesis	Serpina12	IDA		Mouse	PMID:22837305
Biological Process	GO:0006006	glucose metabolic process	Serpina12	IEP		Rat	PMID:16030142|RGD:1547845
Biological Process	GO:0008610	lipid biosynthetic process	Serpina12	IDA		Mouse	PMID:22837305
Biological Process	GO:0045721	negative regulation of gluconeogenesis	Serpina12	IDA		Mouse	PMID:22837305
Biological Process	GO:0051055	negative regulation of lipid biosynthetic process	Serpina12	IDA		Mouse	PMID:22837305
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Serpina12	IMP	MGI:MGI:5568548	Mouse	PMID:22837305
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Serpina12	IMP	MGI:MGI:5568548	Mouse	PMID:22837305
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Serpina12	IMP	MGI:MGI:5568548	Mouse	PMID:22837305
Biological Process	GO:0090181	regulation of cholesterol metabolic process	Serpina12	IMP	MGI:MGI:5568548	Mouse	PMID:22837305
Biological Process	GO:0090207	regulation of triglyceride metabolic process	Serpina12	IMP	MGI:MGI:5568548	Mouse	PMID:22837305

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern