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Serpina12
Gene Detail
 Symbol
Name
ID
Serpina12
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
MGI:1915304
Synonyms vaspin
Feature Type protein coding gene
Genetic Map
Chromosome 12
53.05 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:104028769-104044443 bp, - strand
From VEGA annotation of GRCm38

  15675 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23588  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: serpin
Gene Tree: Serpina12

Human
homologs
Human Homolog SERPINA12, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
NCBI Gene ID 145264
neXtProt AC  NX_Q8IW75
Human Synonyms  OL-64
Human Chr (Location)  14q32.13; chr14:94487274-94517844 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice hmomozygous for a knock-out allele exhibit increased body weight, epididymal fat pad weight, liver weight, fat cell size, serum total and small density LDL cholesterol, serum leptin, liver triglyceride and insulin resistance when fed a high fat, high sucrose diet.
 
Interactions
Serpina12 interacts with 240 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process negative regulation of endopeptidase activity, negative regulation of gluconeogenesis, ...
Component extracellular region, extracellular space, ...
Function peptidase inhibitor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 23, 24
Assay TypeResults
RT-PCR 3
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027616 (Evidence)
Ensembl Gene ModelENSMUSG00000041567 (Evidence)
Entrez Gene68054 (Evidence)
UniGene20286
DFCITC1583867, TC1732987
DoTSDT.486001
NIA Mouse Gene IndexU034303
Consensus CDS ProjectCCDS26145.1
International Mouse Knockout Project StatusSerpina12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027616 VEGA Gene Model | MGI Sequence Detail 15675 C57BL/6J ±  kb
transcript OTTMUST00000068349 VEGA | MGI Sequence Detail 3690 Not Applicable 
polypeptide OTTMUSP00000034535 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014681 serpin A12
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208508 Nakatsuka A, et al., Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Diabetes. 2012 Nov;61(11):2823-32
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory