Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SAMHD1
  • Mouse genes Samhd1
  • Rat genes Samhd1
  • Zfish genes samhd1,si:ch211-233g6.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Samhd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032567	dGTP binding	SAMHD1	IDA		Human	PMID:24141705
Molecular Function	GO:0008832	dGTPase activity	SAMHD1	IDA		Human	PMID:23601106
Molecular Function	GO:0008832	dGTPase activity	SAMHD1	IDA		Human	PMID:24217394
Molecular Function	GO:0008832	dGTPase activity	SAMHD1	IDA		Human	PMID:26294762
Molecular Function	GO:0008832	dGTPase activity	Samhd1	IDA		Mouse	MGI:MGI:6114841|PMID:29379009
Molecular Function	GO:0042802	identical protein binding	SAMHD1	IPI	UniProtKB:Q9Y3Z3	Human	PMID:22056990
Molecular Function	GO:0042802	identical protein binding	SAMHD1	IPI	UniProtKB:Q9Y3Z3	Human	PMID:24141705
Molecular Function	GO:0003676	nucleic acid binding	SAMHD1	IDA		Human	PMID:22461318
Molecular Function	GO:0005515	protein binding	SAMHD1	IPI	UniProtKB:P58753	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	SAMHD1	IPI	UniProtKB:P06493	Human	PMID:23601106
Molecular Function	GO:0005515	protein binding	SAMHD1	IPI	UniProtKB:P49959	Human	PMID:28834754
Molecular Function	GO:0005515	protein binding	SAMHD1	IPI	UniProtKB:Q99708	Human	PMID:28834754
Molecular Function	GO:0005515	protein binding	SAMHD1	IPI	UniProtKB:P60033	Human	PMID:28871089
Molecular Function	GO:0005515	protein binding	SAMHD1	IPI	UniProtKB:P49959	Human	PMID:29670289
Molecular Function	GO:0005515	protein binding	SAMHD1	IPI	UniProtKB:Q08380	Human	PMID:30833792
Molecular Function	GO:0003723	RNA binding	SAMHD1	IDA		Human	PMID:22461318
Molecular Function	GO:0004540	RNA nuclease activity	SAMHD1	IDA		Human	PMID:25038827
Molecular Function	GO:0003697	single-stranded DNA binding	SAMHD1	IDA		Human	PMID:29670289
Molecular Function	GO:0016793	triphosphoric monoester hydrolase activity	SAMHD1	IDA		Human	PMID:23601106
Molecular Function	GO:0016793	triphosphoric monoester hydrolase activity	SAMHD1	IDA		Human	PMID:26294762
Molecular Function	GO:0016793	triphosphoric monoester hydrolase activity	Samhd1	IDA		Mouse	MGI:MGI:6114841|PMID:29379009
Molecular Function	GO:0008270	zinc ion binding	SAMHD1	IDA		Human	PMID:24217394
Cellular Component	GO:0005654	nucleoplasm	SAMHD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SAMHD1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	SAMHD1	IDA		Human	PMID:19525956
Cellular Component	GO:0005886	plasma membrane	SAMHD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0035861	site of double-strand break	SAMHD1	IDA		Human	PMID:28834754
Cellular Component	GO:0035861	site of double-strand break	SAMHD1	IDA		Human	PMID:29670289
Cellular Component	GO:0097197	tetraspanin-enriched microdomain	SAMHD1	IDA		Human	PMID:28871089
Biological Process	GO:0046061	dATP catabolic process	SAMHD1	IDA		Human	PMID:24141705
Biological Process	GO:0051607	defense response to virus	SAMHD1	IMP		Human	PMID:19525956
Biological Process	GO:0051607	defense response to virus	SAMHD1	IDA		Human	PMID:23601106
Biological Process	GO:0051607	defense response to virus	SAMHD1	IDA		Human	PMID:26294762
Biological Process	GO:0051607	defense response to virus	Samhd1	IMP		Mouse	MGI:MGI:5521417|PMID:23972988
Biological Process	GO:0009264	deoxyribonucleotide catabolic process	SAMHD1	IDA		Human	PMID:23601106
Biological Process	GO:0009264	deoxyribonucleotide catabolic process	SAMHD1	IDA		Human	PMID:26294762
Biological Process	GO:0006203	dGTP catabolic process	SAMHD1	IDA		Human	PMID:24217394
Biological Process	GO:0006974	DNA damage response	SAMHD1	IDA		Human	PMID:28834754
Biological Process	GO:0006974	DNA damage response	SAMHD1	IDA		Human	PMID:29670289
Biological Process	GO:0110025	DNA strand resection involved in replication fork processing	SAMHD1	IDA		Human	PMID:28834754
Biological Process	GO:0110025	DNA strand resection involved in replication fork processing	SAMHD1	IDA		Human	PMID:29670289
Biological Process	GO:0000724	double-strand break repair via homologous recombination	SAMHD1	IDA		Human	PMID:28834754
Biological Process	GO:0000724	double-strand break repair via homologous recombination	SAMHD1	IDA		Human	PMID:29670289
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	SAMHD1	IDA		Human	PMID:29670289
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Samhd1	IMP		Mouse	MGI:MGI:5521417|PMID:23972988
Biological Process	GO:0051289	protein homotetramerization	SAMHD1	IDA		Human	PMID:23601106
Biological Process	GO:0051289	protein homotetramerization	SAMHD1	IDA		Human	PMID:24217394
Biological Process	GO:0051289	protein homotetramerization	SAMHD1	IDA		Human	PMID:26294762
Biological Process	GO:0051289	protein homotetramerization	Samhd1	IDA		Mouse	MGI:MGI:6114841|PMID:29379009
Biological Process	GO:0045088	regulation of innate immune response	SAMHD1	IMP		Human	PMID:19525956
Biological Process	GO:0045088	regulation of innate immune response	SAMHD1	IDA		Human	PMID:29670289
Biological Process	GO:0045088	regulation of innate immune response	samhd1	IMP	ZFIN:ZDB-MRPHLNO-151009-1	Zfish	PMID:25672750
Biological Process	GO:0045088	regulation of innate immune response	samhd1	IMP	ZFIN:ZDB-MRPHLNO-151009-2	Zfish	PMID:25672750
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Samhd1	IMP		Mouse	MGI:MGI:6157199|PMID:29669924

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern