Samhd1
Gene Detail

Symbol

Name
ID

Samhd1
SAM domain and HD domain, 1
MGI:1927468

Synonyms

E330031J07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2
78.00 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:157097533-157135265 bp, - strand From VEGA annotation of GRCm38   37733 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:9160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Samhd1

Human
homologs

Human Homolog		SAMHD1, SAM domain and HD domain 1
NCBI Gene ID		25939
neXtProt AC		NX_Q9Y3Z3
Human Synonyms		CHBL2, DCIP, HDDC1, MOP-5, SBBI88
Human Chr (Location)		20pter-q12; chr20:36890882-36951843 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human SAMHD1

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit increased susceptibility to infection with pseudotyped HIV-1.

 

Interactions

Samhd1 interacts with 325 markers (Mir7-1, Mir9-1, Mir9-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	dATP catabolic process, defense response to virus, ...
Component	nucleoplasm, nucleus, ...
Function	catalytic activity, dGTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (21)    Tissues (3)    Images (17)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	21

cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(18) cDNA(18)
Microarray probesets(10)

Other database
links

VEGA Gene Model	OTTMUSG00000016173 (Evidence)
Ensembl Gene Model	ENSMUSG00000027639 (Evidence)
Entrez Gene	56045 (Evidence)
DFCI	TC1596516, TC1589092, TC1588180, TC1574281
DoTS	DT.40176252, DT.101400904, DT.528645, DT.87072620, DT.87072624, DT.97354181
NIA Mouse Gene Index	U023575
EC	3.1.5.-
Consensus CDS Project	CCDS16973.2, CCDS50783.1
International Mouse Knockout Project Status	Samhd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016173	VEGA Gene Model | MGI Sequence Detail	37733	C57BL/6J
transcript	OTTMUST00000038703	VEGA | MGI Sequence Detail	3926	Not Applicable
polypeptide	OTTMUSP00000017309	VEGA | MGI Sequence Detail	658	Not Applicable

All sequences(96) RefSeq(6) UniProt(23)

Polymorphisms

SNPs within 2kb(405 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006674	HD domain
InterPro	IPR003607	HD/PDEase domain
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000014443	SAM domain and HD domain-containing protein 1

References

(Earliest) J:23604 Lafuse WP, et al., Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. J Leukoc Biol. 1995 Mar;57(3):477-83
(Latest) J:203798 Zhao K, et al., Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1. Cell Rep. 2013 Sep 26;4(6):1108-15
All references(37)

Other
accession IDs

MGI:2442130