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Samhd1
Gene Detail
Symbol

Name
ID
Samhd1
SAM domain and HD domain, 1
MGI:1927468
Synonyms
E330031J07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
78.00 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:157097533-157135265 bp, - strand
From VEGA annotation of GRCm38

  37733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Samhd1

Human
homologs
Human Homolog SAMHD1, SAM domain and HD domain 1
NCBI Gene ID 25939
neXtProt AC  NX_Q9Y3Z3
Human Synonyms  CHBL2, DCIP, HDDC1, MOP-5, SBBI88
Human Chr (Location)  20pter-q12; chr20:36890882-36951843 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SAMHD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to infection with pseudotyped HIV-1.
 
Interactions
Samhd1 interacts with 325 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dATP catabolic process, defense response to virus, ...
Component nucleus, plasma membrane
Function catalytic activity, dGTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (3)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000016173 (Evidence)
Ensembl Gene ModelENSMUSG00000027639 (Evidence)
Entrez Gene56045 (Evidence)
DFCITC1574281, TC1596516, TC1588180, TC1589092
DoTSDT.101400904, DT.87072624, DT.87072620, DT.528645, DT.40176252, DT.97354181
NIA Mouse Gene IndexU023575
EC3.1.5.-
Consensus CDS ProjectCCDS16973.2, CCDS50783.1
International Mouse Knockout Project StatusSamhd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016173 VEGA Gene Model | MGI Sequence Detail 37733 C57BL/6J ±  kb
transcript OTTMUST00000038703 VEGA | MGI Sequence Detail 3926 Not Applicable 
polypeptide OTTMUSP00000017309 VEGA | MGI Sequence Detail 658 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(6) UniProt(23)
Polymorphisms
SNPs within 2kb(405 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006674 HD domain
InterPro IPR003607 HD/PDEase domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000014443 SAM domain and HD domain-containing protein 1
References
(Earliest) J:23604 Lafuse WP, et al., Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. J Leukoc Biol. 1995 Mar;57(3):477-83
(Latest) J:203798 Zhao K, et al., Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1. Cell Rep. 2013 Sep 26;4(6):1108-15
All references(37)
Other
accession IDs
MGI:2442130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory