Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes S100A4
  • Mouse genes S100a4
  • Rat genes S100a4
  • Zfish genes icn,icn2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set S100a4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	S100a4	IDA		Rat	PMID:8878885|RGD:7205640
Molecular Function	GO:0005509	calcium ion binding	S100a4	IDA		Mouse	PMID:11914069
Molecular Function	GO:0005509	calcium ion binding	S100a4	IDA		Rat	PMID:2357224|RGD:7205642
Molecular Function	GO:0048306	calcium-dependent protein binding	S100a4	IMP		Rat	PMID:15856021|RGD:1547864
Molecular Function	GO:0048306	calcium-dependent protein binding	S100a4	IDA		Rat	PMID:8878885|RGD:7205640
Molecular Function	GO:0042056	chemoattractant activity	S100A4	IDA		Human	PMID:26654597
Molecular Function	GO:0042802	identical protein binding	S100A4	IPI	UniProtKB:P26447	Human	PMID:20421509
Molecular Function	GO:0042802	identical protein binding	S100A4	IPI	UniProtKB:P26447	Human	PMID:22483112
Molecular Function	GO:0042802	identical protein binding	S100a4	IPI	UniProtKB:P07091	Mouse	MGI:MGI:3763311|PMID:10869553
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P35579	Human	PMID:14640694
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P35579	Human	PMID:15479433
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P23297	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04637	Human	PMID:19740107
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P15514	Human	PMID:19740107
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P35070	Human	PMID:19740107
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P35579	Human	PMID:20421509
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04637	Human	PMID:20591429
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:Q00987	Human	PMID:20591429
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04271	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P35579	Human	PMID:22460785
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P35579	Human	PMID:22483112
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P08637	Human	PMID:23024279
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04637	Human	PMID:23752197
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04271	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04271	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P00533	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P15514	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P21860	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:Q15303	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04637	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P15311	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P35579	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:Q8TD43	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:Q9HB71	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P04271	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	S100A4	IPI	UniProtKB:P23297	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	S100a4	IPI	UniProtKB:P56565	Mouse	MGI:MGI:3763311|PMID:10869553
Molecular Function	GO:0005515	protein binding	S100a4	IPI	RGD:732401	Rat	PMID:15856021|RGD:1547864
Molecular Function	GO:0050786	RAGE receptor binding	S100A4	IPI	UniProtKB:Q15109	Human	PMID:15033494
Molecular Function	GO:0003723	RNA binding	S100A4	HDA		Human	PMID:22658674
Cellular Component	GO:0062023	collagen-containing extracellular matrix	S100A4	HDA		Human	PMID:25037231
Cellular Component	GO:0005829	cytosol	S100A4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	S100A4	HDA		Human	PMID:19056867
Cellular Component	GO:0005576	extracellular region	S100A4	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	S100A4	IDA		Human	PMID:26654597
Cellular Component	GO:0005615	extracellular space	S100A4	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	S100A4	HDA		Human	PMID:23580065
Cellular Component	GO:0043005	neuron projection	S100a4	IDA		Rat	PMID:15101091|RGD:1547863
Cellular Component	GO:0005654	nucleoplasm	S100A4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	S100A4	IDA		Human	PMID:12118070
Cellular Component	GO:0005634	nucleus	S100A4	IDA		Human	PMID:15033494
Cellular Component	GO:0048471	perinuclear region of cytoplasm	S100A4	IDA		Human	PMID:15033494
Biological Process	GO:0021782	glial cell development	icn2	IMP	ZFIN:ZDB-CRISPR-191009-37,ZFIN:ZDB-CRISPR-191009-38	Zfish	PMID:30924555
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	S100A4	IDA		Human	PMID:15033494
Biological Process	GO:0060041	retina development in camera-type eye	icn2	IMP	ZFIN:ZDB-CRISPR-191009-37,ZFIN:ZDB-CRISPR-191009-38	Zfish	PMID:30924555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern