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S100a4
Gene Detail
Symbol

Name
ID
S100a4
S100 calcium binding protein A4
MGI:1330282
STS
Synonyms
18A2, 42a, calvasculin, Capl, CAPL, FSp1, metastasin, Mts1, PeL98, pk9a
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.27 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:90603771-90606045 bp, + strand
From VEGA annotation of GRCm38

  2275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7924  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: S-100 protein
Gene Tree: S100a4

Human
homologs
Human Homolog S100A4, S100 calcium binding protein A4
NCBI Gene ID 6275
neXtProt AC  NX_P26447
Human Synonyms  18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98
Human Chr (Location)  1q21; chr1:153543619-153545806 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
 
Mice homozygous for one knock-out allele exhibit impaired chemotaxis of macrophages. Mice homozygous for another knock-out allele exhibit embryonic lethality resulting in a skewed sex ratio and increased tumor incidence.
 
Interactions
S100a4 interacts with 18 markers (Mir7-1, Mir7-2, Mir25, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (52)    Tissues (7)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 50
RT-PCR 2
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(7) cDNA(31) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022114 (Evidence)
Ensembl Gene ModelENSMUSG00000001020 (Evidence)
Entrez Gene20198 (Evidence)
UniGene3925
DFCITC1581621
DoTSDT.536918
NIA Mouse Gene IndexU003500
Consensus CDS ProjectCCDS17538.1
International Mouse Knockout Project StatusS100a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022114 VEGA Gene Model | MGI Sequence Detail 2275 C57BL/6J ±  kb
transcript OTTMUST00000052492 VEGA | MGI Sequence Detail 498 Not Applicable 
polypeptide OTTMUSP00000024898 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Protein Ontology PR:000014411 protein S100-A4
References
(Earliest) J:27240 Jackson-Grusby LL, et al., A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein. Nucleic Acids Res. 1987 Aug 25;15(16):6677-90
(Latest) J:213534 Bruhn S, et al., A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy. Sci Transl Med. 2014 Jan 8;6(218):218ra4
All references(99)
Other
accession IDs
MGD-MRK-12597, MGD-MRK-1758, MGI:88267, MGI:97182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory