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S100a4
Gene Detail
Symbol

Name
ID
S100a4
S100 calcium binding protein A4
MGI:1330282
STS
Synonyms
18A2, 42a, calvasculin, Capl, CAPL, FSp1, metastasin, Mts1, PeL98, pk9a
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.27 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:90603771-90606045 bp, + strand
From VEGA annotation of GRCm38

  2275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7924  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: S100A4
Protein SuperFamily: S-100 protein
Gene Tree: S100a4

Human
homologs
S100A4, S100 calcium binding protein A4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6275
neXtProt AC: NX_P26447

Human Synonyms: 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98

Human Chr (Location): 1q21; chr1:153543619-153545806 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
 
Mice homozygous for one knock-out allele exhibit impaired chemotaxis of macrophages. Mice homozygous for another knock-out allele exhibit embryonic lethality resulting in a skewed sex ratio and increased tumor incidence.
 
Interactions
S100a4 interacts with 18 markers (Mir7-1, Mir7-2, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process positive regulation of I-kappaB kinase/NF-kappaB signaling
Component extracellular exosome, extracellular space, ...
Function actin binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (52)    Tissues (7)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 50
RT-PCR 2
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(7) cDNA(31) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022114 (Evidence)
Ensembl Gene Model ENSMUSG00000001020 (Evidence)
Entrez Gene 20198 (Evidence)
UniGene 3925
DFCI TC1581621
DoTS DT.536918
NIA Mouse Gene Index U003500
Consensus CDS Project CCDS17538.1
International Mouse Phenotyping Consortium Status S100a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022114 VEGA Gene Model | MGI Sequence Detail 2275 C57BL/6J ±  kb
transcript OTTMUST00000052492 VEGA | MGI Sequence Detail 498 Not Applicable 
polypeptide OTTMUSP00000024898 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand domain pair
InterPro IPR028496 Protein S100-A4
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Protein Ontology PR:000014411 protein S100-A4
References
(Earliest) J:223058 Ambartsumian N, et al., Tissue-specific posttranscriptional downregulation of expression of the S100A4(mts1) gene in transgenic animals. Invasion Metastasis. 1998-1999;18(2):96-104
(Latest) J:222170 Luo J, et al., FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice. Endocrinology. 2015 Jun;156(6):2200-10
All references(104)
Other
accession IDs
MGD-MRK-12597, MGD-MRK-1758, MGI:88267, MGI:97182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory