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S100a4 Gene Detail
Summary
  • Symbol
    S100a4
  • Name
    S100 calcium binding protein A4
  • Synonyms
    18A2, 42a, calvasculin, Capl, CAPL, FSp1, metastasin, Mts1, PeL98, pk9a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330282
    NCBI Gene: 20198
  • Gene Overview
    MyGene.info: S100A4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90603771-90606045 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.27 cM, cytoband F1-F2
  • Mapping Data
    9 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330282
protein coding gene Chr3:90603770-90606045 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027475
protein coding gene Chr3:90935285-90937545 (+)
A/J MGP_AJ_G0027439
protein coding gene Chr3:87900274-87902580 (+)
AKR/J MGP_AKRJ_G0027404
protein coding gene Chr3:90066429-90068693 (+)
BALB/cJ MGP_BALBcJ_G0027448
protein coding gene Chr3:87857005-87859723 (+)
C3H/HeJ MGP_C3HHeJ_G0027190
protein coding gene Chr3:90228165-90230429 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027894
protein coding gene Chr3:94340354-94342627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025247
protein coding gene Chr3:83402508-83404748 (+)
CAST/EiJ MGP_CASTEiJ_G0026636
protein coding gene Chr3:90625397-90627718 (+)
CBA/J MGP_CBAJ_G0027165
protein coding gene Chr3:97546680-97548953 (+)
DBA/2J MGP_DBA2J_G0027302
protein coding gene Chr3:87265692-87268011 (+)
FVB/NJ MGP_FVBNJ_G0027270
protein coding gene Chr3:85596144-85598415 (+)
LP/J MGP_LPJ_G0027411
protein coding gene Chr3:91992709-91994992 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027291
protein coding gene Chr3:103789590-103791872 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027953
protein coding gene Chr3:89813924-89816242 (+)
PWK/PhJ MGP_PWKPhJ_G0026370
protein coding gene Chr3:87165155-87167489 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026190
protein coding gene Chr3:88994834-88997119 (+)
WSB/EiJ MGP_WSBEiJ_G0026718
protein coding gene Chr3:90219781-90222107 (+)



Homology
more
  • Human Ortholog
    S100A4, S100 calcium binding protein A4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    S100A4, S100 calcium binding protein A4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98
  • Links
    NCBI Gene ID: 6275
    neXtProt AC: NX_P26447
    UniProt: P26447

  • Chr Location
    1q21.3; chr1:153543619-153545806 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit impaired chemotaxis of macrophages. Mice homozygous for another knock-out allele exhibit embryonic lethality resulting in a skewed sex ratio and increased tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001020 Ensembl Gene Model | MGI Sequence Detail 2275 C57BL/6J ±  kb
    transcript ENSMUST00000001046 Ensembl | MGI Sequence Detail 498 Not Applicable  
    polypeptide ENSMUSP00000001046 Ensembl | MGI Sequence Detail 101 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 7
      cDNA 32
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12597, MGD-MRK-1758, MGI:88267, MGI:97182
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 6
      Phenotypes 29
    • Earliest
      J:27240 Jackson-Grusby LL, et al., A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein. Nucleic Acids Res. 1987 Aug 25;15(16):6677-90
    • Latest
      J:264144 Eley L, et al., A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory