Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPS6KA4
  • Mouse genes Rps6ka4
  • Rat genes Rps6ka4
  • Zfish genes rps6ka4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6ka4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	RPS6KA4	IDA		Human	PMID:9792677
Molecular Function	GO:0035175	histone H3S10 kinase activity	RPS6KA4	IMP		Human	PMID:12773393
Molecular Function	GO:0044022	histone H3S28 kinase activity	RPS6KA4	IMP		Human	PMID:12773393
Molecular Function	GO:0005515	protein binding	RPS6KA4	IPI	UniProtKB:Q16539	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	RPS6KA4	IPI	UniProtKB:Q16539	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	RPS6KA4	IPI	UniProtKB:Q16539	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RPS6KA4	IPI	UniProtKB:Q16539	Human	PMID:9792677
Molecular Function	GO:0005515	protein binding	Rps6ka4	IPI	UniProtKB:P63085	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0004674	protein serine/threonine kinase activity	RPS6KA4	IDA		Human	PMID:9792677
Cellular Component	GO:0005829	cytosol	RPS6KA4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RPS6KA4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RPS6KA4	IDA		Human	PMID:11035004
Cellular Component	GO:0005634	nucleus	RPS6KA4	IDA		Human	PMID:9792677
Cellular Component	GO:0045202	synapse	Rps6ka4	IDA		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Rps6ka4	EXP		Mouse	PMID:25211037
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	RPS6KA4	IMP		Human	PMID:20018936
Biological Process	GO:0035556	intracellular signal transduction	RPS6KA4	IDA		Human	PMID:9792677
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RPS6KA4	IMP		Human	PMID:20018936
Biological Process	GO:0043687	post-translational protein modification	RPS6KA4	IMP		Human	PMID:12773393
Biological Process	GO:0006468	protein phosphorylation	RPS6KA4	IDA		Human	PMID:9792677
Biological Process	GO:0006355	regulation of DNA-templated transcription	RPS6KA4	IDA		Human	PMID:9792677

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern