About   Help   FAQ
Rps6ka4 Gene Detail
Summary
  • Symbol
    Rps6ka4
  • Name
    ribosomal protein S6 kinase, polypeptide 4
  • Synonyms
    1110069D02Rik, 90kDa, MSK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930076
    NCBI Gene: 56613
  • Gene Overview
    MyGene.info: RPS6KA4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6829085-6840601 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930076
protein coding gene Chr19:6829084-6840989 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024766
protein coding gene Chr19:3914666-3926057 (-)
A/J MGP_AJ_G0024732
protein coding gene Chr19:3587281-3598683 (-)
AKR/J MGP_AKRJ_G0024705
protein coding gene Chr19:3700616-3712001 (-)
BALB/cJ MGP_BALBcJ_G0024732
protein coding gene Chr19:3699580-3710965 (-)
C3H/HeJ MGP_C3HHeJ_G0024500
protein coding gene Chr19:3829164-3840611 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025178
protein coding gene Chr19:4004239-4015628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022612
protein coding gene Chr19:3498630-3510009 (-)
CAST/EiJ MGP_CASTEiJ_G0023972
protein coding gene Chr19:3736318-3747769 (-)
CBA/J MGP_CBAJ_G0024472
protein coding gene Chr19:4051367-4062763 (-)
DBA/2J MGP_DBA2J_G0024599
protein coding gene Chr19:3563602-3575003 (-)
FVB/NJ MGP_FVBNJ_G0024565
protein coding gene Chr19:3582287-3593720 (-)
LP/J MGP_LPJ_G0024685
protein coding gene Chr19:3757756-3769141 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024594
protein coding gene Chr19:3957760-3970423 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025226
protein coding gene Chr19:3839658-3851048 (-)
PWK/PhJ MGP_PWKPhJ_G0023718
protein coding gene Chr19:3603773-3615048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023523
protein coding gene Chr19:3659960-3671182 (-)
WSB/EiJ MGP_WSBEiJ_G0024034
protein coding gene Chr19:3733491-3744879 (-)



Homology
more
  • Human Ortholog
    RPS6KA4, ribosomal protein S6 kinase A4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RPS6KA4, ribosomal protein S6 kinase A4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSK2, RSK-B, S6K-alpha-4
  • Links
    NCBI Gene ID: 8986
    neXtProt AC: NX_O75676
    UniProt: O75676

  • Chr Location
    11q13.1; chr11:64359153-64372215 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from multigenic genotypes
    30 phenotype references
No phenotypic information associated with mutations in this gene have been reported.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024952 Ensembl Gene Model | MGI Sequence Detail 11517 C57BL/6J ±  kb
transcript ENSMUST00000170516 Ensembl | MGI Sequence Detail 3105 Not Applicable  
polypeptide ENSMUSP00000131581 Ensembl | MGI Sequence Detail 773 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 61
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916134, MGI:2147615
References
more
  • Summaries
    All 62
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 30
  • Earliest
    J:49137 Deak M, et al., Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41
  • Latest
    J:242992 McGuire VA, et al., Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways. Mol Cell Biol. 2017 Jan 01;37(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory