About   Help   FAQ
Rps6ka4 Gene Detail
Summary
  • Symbol
    Rps6ka4
  • Name
    ribosomal protein S6 kinase, polypeptide 4
  • Synonyms
    1110069D02Rik, 90kDa, MSK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930076
    NCBI Gene: 56613
  • Gene Overview
    MyGene.info: RPS6KA4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6806578-6818004 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930076
protein coding gene Chr19:6806573-6819513 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RPS6KA4, ribosomal protein S6 kinase A4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS6KA4, ribosomal protein S6 kinase A4
  • Synonyms
    MSK2, RSK-B, S6K-alpha-4
  • Links
    NCBI Gene ID: 8986
    neXtProt AC: NX_O75676
    UniProt: O75676

  • Chr Location
    11q13.1; chr11:64359153-64372215 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from multigenic genotypes
    30 phenotype references
No phenotypic information associated with mutations in this gene have been reported.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000118668 Ensembl Gene Model | MGI Sequence Detail 11427 C57BL/6J ±  kb
transcript ENSMUST00000239527 Ensembl | MGI Sequence Detail 3140 Not Applicable  
polypeptide ENSMUSP00000159422 Ensembl | MGI Sequence Detail 773 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 61
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916134, MGI:2147615
References
more
  • Summaries
    All 61
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 30
  • Earliest
    J:49137 Deak M, et al., Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41
  • Latest
    J:258440 Sutavani RV, et al., Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018 Feb 16;293(7):2302-2317

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/07/2021
MGI 6.17
The Jackson Laboratory