Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RNF186
  • Mouse genes Rnf186
  • Rat genes Rnf186
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rnf186

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140677	molecular function activator activity	RNF186	IDA		Human	PMID:33280498
Molecular Function	GO:0005515	protein binding	RNF186	IPI	UniProtKB:Q12981	Human	PMID:23896122
Molecular Function	GO:0005515	protein binding	RNF186	IPI	UniProtKB:P57086	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF186	IPI	UniProtKB:Q96AL5	Human	PMID:32296183
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RNF186	IDA		Human	PMID:33280498
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RNF186	IDA		Human	PMID:23896122
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF186	IDA		Human	PMID:23896122
Cellular Component	GO:0005783	endoplasmic reticulum	RNF186	IDA		Human	PMID:23896122
Cellular Component	GO:0005789	endoplasmic reticulum membrane	RNF186	IDA		Human	PMID:23896122
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	RNF186	IMP		Human	PMID:23896122
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RNF186	IDA		Human	PMID:23896122
Biological Process	GO:0051865	protein autoubiquitination	RNF186	IDA		Human	PMID:23896122
Biological Process	GO:0035519	protein K29-linked ubiquitination	RNF186	IDA		Human	PMID:23896122
Biological Process	GO:0070534	protein K63-linked ubiquitination	RNF186	IDA		Human	PMID:23896122
Biological Process	GO:0070585	protein localization to mitochondrion	RNF186	IMP		Human	PMID:23896122
Biological Process	GO:2000785	regulation of autophagosome assembly	RNF186	IDA		Human	PMID:33280498

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern