Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RIT2
  • Mouse genes Rit2
  • Rat genes Rit2
  • Zfish genes rit1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rit2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005516	calmodulin binding	RIT2	IDA		Human	PMID:8918462
Molecular Function	GO:0005516	calmodulin binding	Rit2	IPI	UniProtKB:P62157	Mouse	MGI:MGI:5784991|PMID:14662747
Molecular Function	GO:0005516	calmodulin binding	Rit2	IDA		Mouse	MGI:MGI:83508|PMID:8824319
Molecular Function	GO:0003682	chromatin binding	Rit2	IGI	UniProtKB:P17208	Mouse	MGI:MGI:5784992|PMID:12934100
Molecular Function	GO:0005525	GTP binding	Rit2	IDA		Mouse	MGI:MGI:4456963|PMID:10545207
Molecular Function	GO:0005525	GTP binding	Rit2	IDA		Mouse	MGI:MGI:83508|PMID:8824319
Molecular Function	GO:0003924	GTPase activity	Rit2	IDA		Mouse	MGI:MGI:4456963|PMID:10545207
Molecular Function	GO:0005515	protein binding	RIT2	IPI	UniProtKB:Q01959	Human	PMID:21957239
Molecular Function	GO:0005515	protein binding	RIT2	IPI	UniProtKB:Q3MIN7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rit2	IPI	UniProtKB:Q13129	Mouse	MGI:MGI:4456963|PMID:10545207
Molecular Function	GO:0005515	protein binding	Rit2	IPI	UniProtKB:P17208	Mouse	MGI:MGI:5784992|PMID:12934100
Molecular Function	GO:0005515	protein binding	Rit2	IPI	UniProtKB:Q3UYI5	Mouse	MGI:MGI:1889089|PMID:10869344
Molecular Function	GO:0005515	protein binding	Rit2	IPI	UniProtKB:Q01959	Rat	PMID:21957239|RGD:12911003
Molecular Function	GO:0030215	semaphorin receptor binding	RIT2	IPI	UniProtKB:Q9ULL4	Human	PMID:16122393
Cellular Component	GO:0044297	cell body	Rit2	IDA		Mouse	MGI:MGI:5784972|PMID:23805044
Cellular Component	GO:0005737	cytoplasm	Rit2	IDA		Mouse	MGI:MGI:5784992|PMID:12934100
Cellular Component	GO:0005829	cytosol	RIT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0097447	dendritic tree	Rit2	IDA		Mouse	MGI:MGI:5784972|PMID:23805044
Cellular Component	GO:0005794	Golgi apparatus	RIT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045121	membrane raft	RIT2	IDA		Human	PMID:21957239
Cellular Component	GO:0043005	neuron projection	RIT2	IDA		Human	PMID:21957239
Cellular Component	GO:0005654	nucleoplasm	RIT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RIT2	IDA		Human	PMID:16122393
Cellular Component	GO:0005634	nucleus	Rit2	IDA		Mouse	MGI:MGI:5784992|PMID:12934100
Cellular Component	GO:0005886	plasma membrane	RIT2	IDA		Human	PMID:16122393
Cellular Component	GO:0005886	plasma membrane	RIT2	IDA		Human	PMID:21957239
Cellular Component	GO:0005886	plasma membrane	Rit2	IDA		Mouse	MGI:MGI:83508|PMID:8824319
Cellular Component	GO:0005886	plasma membrane	Rit2	IDA		Mouse	MGI:MGI:5784972|PMID:23805044
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rit2	IMP		Rat	PMID:18541665|RGD:2325271
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	rit1	IMP		Zfish	PMID:23791108
Biological Process	GO:0007507	heart development	rit1	IMP		Zfish	PMID:23791108
Biological Process	GO:0035556	intracellular signal transduction	RIT2	IDA		Human	PMID:21957239
Biological Process	GO:0032507	maintenance of protein location in cell	RIT2	IMP		Human	PMID:21957239
Biological Process	GO:0010977	negative regulation of neuron projection development	Rit2	IGI	UniProtKB:P61589	Mouse	MGI:MGI:5784991|PMID:14662747
Biological Process	GO:0043410	positive regulation of MAPK cascade	Rit2	IMP		Rat	PMID:16157584|RGD:11344942
Biological Process	GO:0010976	positive regulation of neuron projection development	RIT2	IGI	UniProtKB:Q5BJQ5	Human	PMID:16157584
Biological Process	GO:0010976	positive regulation of neuron projection development	Rit2	IGI	UniProtKB:P01139	Mouse	MGI:MGI:2179663|PMID:11877426
Biological Process	GO:0010976	positive regulation of neuron projection development	Rit2	IDA		Mouse	MGI:MGI:5784991|PMID:14662747
Biological Process	GO:0010976	positive regulation of neuron projection development	Rit2	IGI	UniProtKB:Q99578	Rat	PMID:16157584|RGD:11344942
Biological Process	GO:0010976	positive regulation of neuron projection development	Rit2	IMP		Rat	PMID:16157584|RGD:11344942
Biological Process	GO:0010976	positive regulation of neuron projection development	Rit2	IGI	UniProtKB:P13589	Rat	PMID:18541665|RGD:2325271
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rit2	IGI	UniProtKB:P17208-1	Mouse	MGI:MGI:5784992|PMID:12934100
Biological Process	GO:0007265	Ras protein signal transduction	Rit2	IDA		Mouse	MGI:MGI:2179663|PMID:11877426
Biological Process	GO:0007265	Ras protein signal transduction	Rit2	IGI	UniProtKB:Q61411	Mouse	MGI:MGI:2179663|PMID:11877426
Biological Process	GO:0050848	regulation of calcium-mediated signaling	Rit2	IMP		Rat	PMID:14662747|RGD:11344946
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	Rit2	IDA		Mouse	MGI:MGI:5784991|PMID:14662747
Biological Process	GO:0030100	regulation of endocytosis	RIT2	IMP		Human	PMID:21957239
Biological Process	GO:0001932	regulation of protein phosphorylation	Rit2	IGI	UniProtKB:P13589	Rat	PMID:18541665|RGD:2325271

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern