Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RCC2
  • Mouse genes Rcc2
  • Rat genes Rcc2
  • Zfish genes rcc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rcc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008017	microtubule binding	RCC2	IMP		Human	PMID:12919680
Molecular Function	GO:0005515	protein binding	RCC2	IPI	UniProtKB:Q14247	Human	PMID:22282019
Molecular Function	GO:0005515	protein binding	RCC2	IPI	UniProtKB:Q60598	Human	PMID:22282019
Molecular Function	GO:0005515	protein binding	RCC2	IPI	UniProtKB:P46940	Human	PMID:25074804
Molecular Function	GO:0005515	protein binding	RCC2	IPI	UniProtKB:Q5JSL3	Human	PMID:25074804
Molecular Function	GO:0005515	protein binding	RCC2	IPI	UniProtKB:Q9H0H5	Human	PMID:25074804
Molecular Function	GO:0005515	protein binding	RCC2	IPI	UniProtKB:Q9NWT1	Human	PMID:25074804
Molecular Function	GO:0019904	protein domain specific binding	RCC2	IPI	UniProtKB:Q9ULV4	Human	PMID:25074804
Molecular Function	GO:0019901	protein kinase binding	RCC2	IPI	UniProtKB:O96013	Human	PMID:25074804
Molecular Function	GO:0003723	RNA binding	RCC2	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	RCC2	HDA		Human	PMID:22681889
Molecular Function	GO:0031267	small GTPase binding	RCC2	IPI	UniProtKB:P63000	Human	PMID:12919680
Molecular Function	GO:0031267	small GTPase binding	RCC2	IPI	UniProtKB:P60953	Human	PMID:25074804
Molecular Function	GO:0031267	small GTPase binding	Rcc2	IPI	UniProtKB:P63001	Mouse	MGI:MGI:5621257|PMID:25074804
Cellular Component	GO:0034506	chromosome, centromeric core domain	RCC2	IDA		Human	PMID:12919680
Cellular Component	GO:0031901	early endosome membrane	Rcc2	IDA		Mouse	MGI:MGI:5621257|PMID:25074804
Cellular Component	GO:0016020	membrane	RCC2	IDA		Human	PMID:25074804
Cellular Component	GO:0030496	midbody	RCC2	IDA		Human	PMID:12919680
Cellular Component	GO:1990023	mitotic spindle midzone	RCC2	IDA		Human	PMID:12919680
Cellular Component	GO:0005634	nucleus	Rcc2	IDA		Mouse	MGI:MGI:5621257|PMID:25074804
Cellular Component	GO:0005886	plasma membrane	Rcc2	IDA		Mouse	MGI:MGI:5621257|PMID:25074804
Biological Process	GO:0090630	activation of GTPase activity	Rcc2	IGI	UniProtKB:Q9WUM4	Mouse	MGI:MGI:5621257|PMID:25074804
Biological Process	GO:0072356	chromosome passenger complex localization to kinetochore	RCC2	IMP		Human	PMID:12919680
Biological Process	GO:0045184	establishment of protein localization	Rcc2	IGI	UniProtKB:Q9WUM4	Mouse	MGI:MGI:5621257|PMID:25074804
Biological Process	GO:0048041	focal adhesion assembly	RCC2	IDA		Human	PMID:19738201
Biological Process	GO:0007229	integrin-mediated signaling pathway	RCC2	IDA		Human	PMID:19738201
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	Rcc2	IMP		Mouse	MGI:MGI:5551375|PMID:19738201
Biological Process	GO:0034260	negative regulation of GTPase activity	RCC2	IMP		Human	PMID:25074804
Biological Process	GO:0034260	negative regulation of GTPase activity	Rcc2	IMP		Mouse	MGI:MGI:5621257|PMID:25074804
Biological Process	GO:0034260	negative regulation of GTPase activity	Rcc2	IMP		Mouse	MGI:MGI:5551375|PMID:19738201
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	Rcc2	IMP		Mouse	MGI:MGI:5551375|PMID:19738201
Biological Process	GO:0001755	neural crest cell migration	rcc2	IMP		Zfish	PMID:25074804|ZFIN:ZDB-PUB-140731-3
Biological Process	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	RCC2	IMP		Human	PMID:12919680
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	RCC2	IMP		Human	PMID:12919680
Biological Process	GO:0030334	regulation of cell migration	Rcc2	IMP		Mouse	MGI:MGI:5551375|PMID:19738201
Biological Process	GO:0010762	regulation of fibroblast migration	Rcc2	IMP		Mouse	MGI:MGI:5621257|PMID:25074804
Biological Process	GO:1900027	regulation of ruffle assembly	Rcc2	IGI	UniProtKB:Q9WUM4	Mouse	MGI:MGI:5621257|PMID:25074804
Biological Process	GO:1900027	regulation of ruffle assembly	Rcc2	IMP		Mouse	MGI:MGI:5621257|PMID:25074804

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern