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Rcc2 Gene Detail
Summary
  • Symbol
    Rcc2
  • Name
    regulator of chromosome condensation 2
  • Synonyms
    2610510H01Rik, 2610529N02Rik, mKIAA1470, Td60
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919784
    NCBI Gene: 108911
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:140427852-140450531 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 72.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    642 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919784
 protein coding gene Chr4:140427308-140450531 (+)
129S1/SvImJ ENSMUSG00200042006
 protein coding gene Chr4:133847931-133870017 (+)
A/J ENSMUSG00195029292
 protein coding gene Chr4:135193592-135216271 (+)
AKR/J ENSMUSG00220047523
 protein coding gene Chr4:134193476-134215564 (+)
BALB/cJ ENSMUSG00180042540
 protein coding gene Chr4:132833334-132855421 (+)
C3H/HeJ ENSMUSG00175032800
 protein coding gene Chr4:133861346-133884025 (+)
C57BL/6NJ ENSMUSG00215047305
 protein coding gene Chr4:135379163-135401843 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026722
 protein coding gene Chr4:130382323-130406689 (+)
CAST/EiJ ENSTCUG00005013217
 protein coding gene Chr4:134818170-134840713 (+)
CBA/J ENSMUSG00210026694
 protein coding gene Chr4:133485354-133508033 (+)
DBA/2J ENSMUSG00185048692
 protein coding gene Chr4:134995524-135017610 (+)
FVB/NJ ENSMUSG00205040344
 protein coding gene Chr4:133256570-133278692 (+)
JF1/MsJ ENSUMUG00000044086
 protein coding gene Chr4:135686987-135709667 (+)
LP/J ENSMUSG00230033126
 protein coding gene Chr4:138785891-138808909 (+)
NOD/ShiLtJ ENSMUSG00190021738
 protein coding gene Chr4:133251431-133273530 (+)
NZO/HlLtJ ENSMUSG00225008022
 protein coding gene Chr4:144742474-144765567 (+)
PWK/PhJ ENSLUMG00010039848
 protein coding gene Chr4:132681117-132703193 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005040222
 protein coding gene Chr4:133136604-133158680 (+)



Homology
more
  • Human Ortholog
    RCC2, regulator of chromosome condensation 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RCC2, regulator of chromosome condensation 2
  • Synonyms
    TD-60
  • Links
    NCBI Gene ID: 55920
    UniProt: Q9P258

  • Chr Location
    1p36.13; chr1:17406755-17439772 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    73
  • cDNA Data
    244
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040945 Ensembl Gene Model | MGI Sequence Detail 22680 C57BL/6J ±  kb
    transcript ENSMUST00000038893 Ensembl | MGI Sequence Detail 3767 Not Applicable  
    polypeptide ENSMUSP00000038144 Ensembl | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013834 protein RCC2
      (term hierarchy)
    • InterPro Domains
      IPR028641 Protein RCC2
      IPR058923 RCC1-like domain
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
    • GlyGen
      Q8BK67 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 244
      cDNA 244

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917298, MGI:2140160, MGI:2140174
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:373437 Cui X, et al., RCC2 and CD24 cooperate to modulate prostate cancer progression through vimentin ubiquitination and beta-catenin activation. J Clin Invest. 2025 Oct 15;135(20)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory