Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PYCR1
  • Mouse genes Pycr1
  • Rat genes Pycr1
  • Zfish genes pycr1a,pycr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pycr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	PYCR1	IPI	UniProtKB:P32322	Human	PMID:16730026
Molecular Function	GO:0042802	identical protein binding	PYCR1	IPI	UniProtKB:P32322	Human	PMID:2722838
Molecular Function	GO:0005515	protein binding	PYCR1	IPI	UniProtKB:Q99497	Human	PMID:23743200
Molecular Function	GO:0005515	protein binding	PYCR1	IPI	UniProtKB:Q8WV07	Human	PMID:24930674
Molecular Function	GO:0005515	protein binding	PYCR1	IPI	UniProtKB:O14787-2	Human	PMID:32296183
Molecular Function	GO:0004735	pyrroline-5-carboxylate reductase activity	PYCR1	IDA		Human	PMID:16730026
Molecular Function	GO:0004735	pyrroline-5-carboxylate reductase activity	PYCR1	IDA		Human	PMID:23743200
Cellular Component	GO:0005739	mitochondrion	PYCR1	IDA		Human	PMID:19648921
Cellular Component	GO:0005739	mitochondrion	PYCR1	IDA		Human	PMID:23743200
Cellular Component	GO:0005739	mitochondrion	Pycr1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pycr1	HDA		Mouse	PMID:18614015
Biological Process	GO:0007420	brain development	pycr1b	IMP	ZFIN:ZDB-MRPHLNO-150623-4	Zfish	PMID:25865492
Biological Process	GO:0034599	cellular response to oxidative stress	PYCR1	IMP		Human	PMID:19648921
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	PYCR1	IMP		Human	PMID:23743200
Biological Process	GO:0006561	proline biosynthetic process	PYCR1	IDA		Human	PMID:16730026
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	PYCR1	IMP		Human	PMID:23743200

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern