Pycr1
Gene Detail

Symbol Name ID

Pycr1 pyrroline-5-carboxylate reductase 1 MGI:2384795

Synonyms

MGC:11688

Feature Type

protein coding gene

Genetic Map

Chromosome 11

84.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:120639416-120643769 bp, - strand From VEGA annotation of GRCm38   4354 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56002  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: pyrroline-5-carboxylate reductase
Gene Tree: Pycr1

Human homologs

Human Homolog		PYCR1, pyrroline-5-carboxylate reductase 1
NCBI Gene ID		5831
neXtProt AC		NX_P32322
Human Synonyms		ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
Human Chr (Location)		17q25.3; chr17:79890267-79894968 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PYCR1

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cellular amino acid biosynthetic process, cellular response to oxidative stress, ...
Component	mitochondrion
Function	identical protein binding, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (198)    Tissues (106)    Images (33)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	198

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) cDNA(34)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000004087 (Evidence)
Ensembl Gene Model	ENSMUSG00000025140 (Evidence)
Entrez Gene	209027 (Evidence)
UniGene	127731
DFCI	TC1581089
DoTS	DT.525260, DT.55197683, DT.91286873
NIA Mouse Gene Index	U185129
EC	1.5.1.2
Consensus CDS Project	CCDS25749.1
International Mouse Knockout Project Status	Pycr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004087	VEGA Gene Model | MGI Sequence Detail	4354	C57BL/6J
transcript	OTTMUST00000009191	VEGA | MGI Sequence Detail	1861	Not Applicable
polypeptide	OTTMUSP00000004476	VEGA | MGI Sequence Detail	309	Not Applicable

All sequences(43) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008927	6-phosphogluconate dehydrogenase, C-terminal-like
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR004455	NADP oxidoreductase, coenzyme F420-dependent
InterPro	IPR000304	Pyrroline-5-carboxylate reductase
Protein Ontology	PR:000013515	pyrroline-5-carboxylate reductase 1, mitochondrial

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)