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Pycr1
Gene Detail
Symbol

Name
ID
Pycr1
pyrroline-5-carboxylate reductase 1
MGI:2384795
Synonyms
MGC:11688
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:120639416-120643769 bp, - strand
From VEGA annotation of GRCm38

  4354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56002  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: pyrroline-5-carboxylate reductase
Gene Tree: Pycr1

Human
homologs
Human Homolog PYCR1, pyrroline-5-carboxylate reductase 1
NCBI Gene ID 5831
neXtProt AC  NX_P32322
Human Synonyms  ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
Human Chr (Location)  17q25.3; chr17:81932384-81937328 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PYCR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pycr1 interacts with 187 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular amino acid biosynthetic process, cellular response to oxidative stress, ...
Component mitochondrion
Function identical protein binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (198)    Tissues (106)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 198
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(34)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000004087 (Evidence)
Ensembl Gene ModelENSMUSG00000025140 (Evidence)
Entrez Gene209027 (Evidence)
UniGene127731
DFCITC1581089
DoTSDT.525260, DT.55197683, DT.91286873
NIA Mouse Gene IndexU185129
EC1.5.1.2
Consensus CDS ProjectCCDS25749.1
International Mouse Knockout Project StatusPycr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004087 VEGA Gene Model | MGI Sequence Detail 4354 C57BL/6J ±  kb
transcript OTTMUST00000009191 VEGA | MGI Sequence Detail 1861 Not Applicable 
polypeptide OTTMUSP00000004476 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000304 Pyrroline-5-carboxylate reductase
Protein Ontology PR:000013515 pyrroline-5-carboxylate reductase 1, mitochondrial
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:203207 Yasuda T, et al., DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. Biochem Biophys Res Commun. 2013 Jun 28;436(2):289-94
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory