Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRRX2
  • Mouse genes Prrx2
  • Rat genes Prrx2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prrx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Prrx2	IMP		Mouse	MGI:MGI:5827899|PMID:12713735
Molecular Function	GO:0071837	HMG box domain binding	Prrx2	IPI	UniProtKB:Q04886	Mouse	MGI:MGI:5284787|PMID:16582099
Molecular Function	GO:0016251	RNA polymerase II general transcription initiation factor activity	Prrx2	IDA		Mouse	PMID:32188878
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Prrx2	IMP		Mouse	MGI:MGI:5827899|PMID:12713735
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PRRX2	IDA		Human	PMID:28473536
Biological Process	GO:0048844	artery morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:10664157
Biological Process	GO:0051216	cartilage development	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9876178
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9729491
Biological Process	GO:0030326	embryonic limb morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9729491
Biological Process	GO:0030326	embryonic limb morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9882503
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9876178
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:11532916
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9729491
Biological Process	GO:0042472	inner ear morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9729491
Biological Process	GO:0010463	mesenchymal cell proliferation	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:11532916
Biological Process	GO:0042474	middle ear morphogenesis	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:9729491
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:11532916
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:11532916
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:11532916
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Prrx2	IMP		Mouse	MGI:MGI:5827899|PMID:12713735
Biological Process	GO:0007224	smoothened signaling pathway	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:11532916
Biological Process	GO:0072089	stem cell proliferation	Prrx2	IGI	MGI:MGI:97712	Mouse	PMID:11532916

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern