Prrx2 MGI Mouse Gene Detail - MGI:98218 - paired related homeobox 2

Prrx2 Gene Detail

Symbol

Prrx2
Name

paired related homeobox 2
Synonyms

Prx2, S8

Feature Type

protein coding gene
IDs

MGI:98218
NCBI Gene: 20204
Gene Overview

MyGene.info: PRRX2

Sequence Map

Chr2:30834972-30881251 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

46280 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.74 cM
Mapping Data

4 experiments

Human Ortholog

PRRX2, paired related homeobox 2

Vertebrate Orthologs

9

Human Ortholog

PRRX2, paired related homeobox 2
Orthology source: HomoloGene, HGNC
Synonyms

PMX2, PRX2
Links

HGNC:21338

NCBI Gene ID: 51450

neXtProt AC: NX_Q99811
Chr Location

9q34.1; chr9:129665641-129722674 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 7524
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
HCOP

human homology predictions: PRRX2
Gene Tree

Prrx2

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
83 phenotypes from multigenic genotypes
10 phenotype references

All Mutations and Alleles

17
Gene trapped

15
Targeted

2

Homozygotes for targeted null mutations are phenotypically normal, but Prrx1/Prrx2 double knockout homozygotes exhibit more severe skeletal defects than Prrx1 single knockout mutants, involving structures unaffected in the latter.

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All GO Annotations

16
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

458
Tissues

296
cDNA Data

52
Literature Summary

34

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase prrx2

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Prrx2 interacts with 87 markers (Mir17, Mir20b, Mir29b-2, ...) View All

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All Sequences

30
RefSeq

4
UniProt

3
CCDS

CCDS15888.1
UniGene

1802

			Length	Strain/Species	Flank
genomic	OTTMUSG00000011872	VEGA Gene Model \| MGI Sequence Detail	46280	C57BL/6J	± kb
transcript	OTTMUST00000027965	VEGA \| MGI Sequence Detail	1441	Not Applicable
polypeptide	OTTMUSP00000012690	VEGA \| MGI Sequence Detail	247	Not Applicable

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SNPs within 2kb

117 from dbSNP Build 142

RFLP

1

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UniProt

3 Sequences
Protein Ontology

PR:000013317 paired mesoderm homeobox protein 2
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeodomain-like

IPR003654 OAR domain

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All nucleic 61

Genomic 1

cDNA 54

Primer pair 3

Other 3

Microarray probesets 3

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MGD-MRK-14270

Summaries

All 64

Developmental Gene Expression 34

Gene Ontology 8

Phenotypes 10
Earliest

J:11448 Opstelten DJ, et al., The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech Dev. 1991 Mar;34(1):29-41
Latest

J:231885 Beccari L, et al., A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. Genes Dev. 2016 May 15;30(10):1172-86

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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