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Prrx2
Gene Detail
Symbol

Name
ID
Prrx2
paired related homeobox 2
MGI:98218
Synonyms
Prx2, S8
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:30834972-30881251 bp, + strand
From VEGA annotation of GRCm38

  46280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PRRX2
Gene Tree: Prrx2

Human
homologs
PRRX2, paired related homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51450
neXtProt AC: NX_Q99811

Human Synonyms: PMX2, PRX2

Human Chr (Location): 9q34.1; chr9:129665641-129722674 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(15) Targeted(2)
 
Homozygotes for targeted null mutations are phenotypically normal, but Prrx1/Prrx2 double knockout homozygotes exhibit more severe skeletal defects than Prrx1 single knockout mutants, involving structures unaffected in the latter.
 
Interactions
Prrx2 interacts with 87 markers (Mir17, Mir20b, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process artery morphogenesis, cartilage development, ...
Component nucleus
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (458)    Tissues (296)    Images (111)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 422
In situ reporter (knock in) 31
Northern blot 3
RT-PCR 2
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prrx2    NEW 
Molecular
reagents
All nucleic(61) Genomic(1) cDNA(54) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011872 (Evidence)
Ensembl Gene Model ENSMUSG00000039476 (Evidence)
Entrez Gene 20204 (Evidence)
UniGene 1802
DFCI TC1582311, TC1595333, TC1779036
DoTS DT.110737770, DT.531443, DT.94191859
NIA Mouse Gene Index U001592
Consensus CDS Project CCDS15888.1
International Mouse Phenotyping Consortium Status Prrx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011872 VEGA Gene Model | MGI Sequence Detail 46280 C57BL/6J ±  kb
transcript OTTMUST00000027965 VEGA | MGI Sequence Detail 1441 Not Applicable 
polypeptide OTTMUSP00000012690 VEGA | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000013317 paired mesoderm homeobox protein 2
References
(Earliest) J:11448 Opstelten DJ, et al., The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech Dev. 1991 Mar;34(1):29-41
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(66)
Other
accession IDs
MGD-MRK-14270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory