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Prrx2
Gene Detail
 Symbol
Name
ID
Prrx2
paired related homeobox 2
MGI:98218
Synonyms Prx2, S8
Feature Type protein coding gene
Genetic Map
Chromosome 2
21.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:30834972-30881251 bp, + strand
From VEGA annotation of GRCm38

  46280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Prrx2

Human
homologs
Human Homolog PRRX2, paired related homeobox 2
NCBI Gene ID 51450
neXtProt AC  NX_Q99811
Human Synonyms  PMX2, PRX2
Human Chr (Location)  9q34.1; chr9:129665641-129722674 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(15) Targeted(2)
 
Homozygotes for targeted null mutations are phenotypically normal, but Prrx1/Prrx2 double knockout homozygotes exhibit more severe skeletal defects than Prrx1 single knockout mutants, involving structures unaffected in the latter.
 
Interactions
Prrx2 interacts with 88 markers (Mir17, Mir20b, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process artery morphogenesis, cartilage development, ...
Component nucleus
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (458)    Tissues (296)    Images (111)
Theiler Stages: 9, 10, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 422
In situ reporter (knock in) 31
Northern blot 3
RT-PCR 2
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(61) Genomic(1) cDNA(54) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011872 (Evidence)
Ensembl Gene ModelENSMUSG00000039476 (Evidence)
Entrez Gene20204 (Evidence)
UniGene1802
DFCITC1582311, TC1595333, TC1779036
DoTSDT.110737770, DT.531443, DT.94191859
NIA Mouse Gene IndexU001592
Consensus CDS ProjectCCDS15888.1
International Mouse Knockout Project StatusPrrx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011872 VEGA Gene Model | MGI Sequence Detail 46280 C57BL/6J ±  kb
transcript OTTMUST00000027965 VEGA | MGI Sequence Detail 1441 Not Applicable 
polypeptide OTTMUSP00000012690 VEGA | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000013317 paired mesoderm homeobox protein 2
References (Earliest) J:11448 Opstelten DJ, et al., The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech Dev. 1991 Mar;34(1):29-41
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(67)
Other
accession IDs
MGD-MRK-14270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory