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Prrx2 Gene Detail
Summary
  • Symbol
    Prrx2
  • Name
    paired related homeobox 2
  • Synonyms
    Prx2, S8
  • Feature Type
    protein coding gene
  • IDs
    MGI:98218
    NCBI Gene: 20204
  • Gene Overview
    MyGene.info: PRRX2
Location & Maps
more
  • Sequence Map
    Chr2:30834972-30881251 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      46280 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.74 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRRX2, paired related homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRRX2, paired related homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PMX2, PRX2
  • Links
    NCBI Gene ID: 51450
    neXtProt AC: NX_Q99811
    UniProt: Q99811

  • Chr Location
    9q34.11; chr9:129665641-129722674 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 7524
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRRX2
  • Gene Tree
    Prrx2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    84 phenotypes from multigenic genotypes
    10 phenotype references
Homozygotes for targeted null mutations are phenotypically normal, but Prrx1/Prrx2 double knockout homozygotes exhibit more severe skeletal defects than Prrx1 single knockout mutants, involving structures unaffected in the latter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    458
  • Tissues
    296
  • cDNA Data
    52
  • Literature Summary
    36
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011872 VEGA Gene Model | MGI Sequence Detail 46280 C57BL/6J ±  kb
transcript OTTMUST00000027965 VEGA | MGI Sequence Detail 1441 Not Applicable  
polypeptide OTTMUSP00000012690 VEGA | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    117 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    Genomic 1
    cDNA 54
    Primer pair 3
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14270
References
more
  • Summaries
    All 66
    Developmental Gene Expression 36
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:11448 Opstelten DJ, et al., The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech Dev. 1991 Mar;34(1):29-41
  • Latest
    J:241567 Tavares ALP, et al., Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 Jun 01;144(11):2021-2031
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory