Prrx2
Gene Detail

Symbol Name ID

Prrx2 paired related homeobox 2 MGI:98218

Synonyms

Prx2, S8

Feature Type

protein coding gene

Genetic Map

Chromosome 2

21.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:30834972-30881255 bp, + strand From VEGA annotation of GRCm38   46284 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Prrx2

Human homologs

Human Homolog		PRRX2, paired related homeobox 2
NCBI Gene ID		51450
neXtProt AC		NX_Q99811
Human Synonyms		PMX2, PRX2
Human Chr (Location)		9q34.1; chr9:129665641-129722674 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(17) : Gene trapped(15) Targeted(2)
 

Homozygotes for targeted null mutations are phenotypically normal, but Prrx1/Prrx2 double knockout homozygotes exhibit more severe skeletal defects than Prrx1 single knockout mutants, involving structures unaffected in the latter.

 

Interactions

Prrx2 interacts with 88 markers (Mir17, Mir20b, Mir29b-2, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	artery morphogenesis, cartilage development, ...
Component	nucleus
Function	DNA binding, HMG box domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)

Data Summary: Results (458)    Tissues (296)    Images (111)
Theiler Stages: 9, 10, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	414
In situ reporter (knock in)	31
Northern blot	3
RT-PCR	2

cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(61) Genomic(1) cDNA(54) Primer pair(3) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011872 (Evidence)
Ensembl Gene Model	ENSMUSG00000039476 (Evidence)
Entrez Gene	20204 (Evidence)
UniGene	1802
DFCI	TC1582311, TC1595333, TC1779036
DoTS	DT.110737770, DT.531443, DT.94191859
NIA Mouse Gene Index	U001592
Consensus CDS Project	CCDS15888.1
International Mouse Knockout Project Status	Prrx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011872	VEGA Gene Model | MGI Sequence Detail	46284	C57BL/6J
transcript	OTTMUST00000027965	VEGA | MGI Sequence Detail	1445	Not Applicable
polypeptide	OTTMUSP00000012690	VEGA | MGI Sequence Detail	247	Not Applicable

All sequences(37) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000013317	paired mesoderm homeobox protein 2

References

(Earliest) J:11448 Opstelten DJ, et al., The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech Dev. 1991 Mar;34(1):29-41
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(67)

Other accession IDs

MGD-MRK-14270