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Prrx2 Gene Detail
Summary
  • Symbol
    Prrx2
  • Name
    paired related homeobox 2
  • Synonyms
    Prx2, S8
  • Feature Type
    protein coding gene
  • IDs
    MGI:98218
    NCBI Gene: 20204
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30735076-30771263 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.74 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98218
 protein coding gene Chr2:30724984-30771263 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025575
 protein coding gene Chr2:29118454-29172400 (+)
A/J MGP_AJ_G0025553
 protein coding gene Chr2:27936665-27982899 (+)
AKR/J MGP_AKRJ_G0025522
 protein coding gene Chr2:28891558-28941769 (+)
BALB/cJ MGP_BALBcJ_G0025549
 protein coding gene Chr2:28072267-28119097 (+)
C3H/HeJ MGP_C3HHeJ_G0025310
 protein coding gene Chr2:28811241-28860607 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025994
 protein coding gene Chr2:30069884-30115960 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023402
 protein coding gene Chr2:26701983-26750134 (+)
CAST/EiJ MGP_CASTEiJ_G0024772
 protein coding gene Chr2:28737746-28799098 (+)
CBA/J MGP_CBAJ_G0025287
 protein coding gene Chr2:31119487-31167876 (+)
DBA/2J MGP_DBA2J_G0025420
 protein coding gene Chr2:27717145-27764443 (+)
FVB/NJ MGP_FVBNJ_G0025383
 protein coding gene Chr2:27551290-27599894 (+)
LP/J MGP_LPJ_G0025506
 protein coding gene Chr2:29026193-29076153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025413
 protein coding gene Chr2:30915686-30965579 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026052
 protein coding gene Chr2:28796145-28844938 (+)
PWK/PhJ MGP_PWKPhJ_G0024519
 protein coding gene Chr2:27579677-27627137 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024319
 protein coding gene Chr2:28929809-28983955 (+)
WSB/EiJ MGP_WSBEiJ_G0024840
 protein coding gene Chr2:28964291-29015929 (+)



Homology
more
  • Human Ortholog
    PRRX2, paired related homeobox 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRRX2, paired related homeobox 2
  • Synonyms
    PMX2, PRX2
  • Links
    NCBI Gene ID: 51450
    neXtProt AC: NX_Q99811
    UniProt: Q99811

  • Chr Location
    9q34.11; chr9:129665641-129722674 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    91 phenotypes from multigenic genotypes
    13 phenotype references
Homozygotes for targeted null mutations are phenotypically normal, but Prrx1/Prrx2 double knockout homozygotes exhibit more severe skeletal defects than Prrx1 single knockout mutants, involving structures unaffected in the latter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1211
  • Tissues
    332
  • cDNA Data
    54
  • Literature Summary
    43
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20204 NCBI Gene Model | MGI Sequence Detail 36188 C57BL/6J ±  kb
transcript NM_009116 RefSeq | MGI Sequence Detail 1150 Not Specified  
polypeptide Q06348 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    Genomic 1
    cDNA 56
    Primer pair 6
    Other 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14270
References
more
  • Summaries
    All 83
    Developmental Gene Expression 43
    Gene Ontology 12
    Phenotypes 13
  • Earliest
    J:31855 Kongsuwan K, et al., Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. EMBO J. 1988 Jul;7(7):2131-8
  • Latest
    J:316178 Gamart J, et al., SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning. Development. 2021 Dec 1;148(23):dev200182
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/22/2022
MGI 6.22 		The Jackson Laboratory