Gene Expression Literature Summary

• Symbol: Prrx2
• Name: paired related homeobox 2
• ID: MGI:98218

44 matching records from 44 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E4.5	E5	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)	1	1	1				1					1			1				1				1				1
In situ RNA (section)				2	1	2		2		3		5		2	5	1	2	1	6		2		2	1		1	3
In situ RNA (whole mount)							1	1	1	3	1	14	1	1	4	1					1
In situ reporter (knock in)								1		1		4		1	1
Northern blot																			1
Western blot																											1
RT-PCR								1				1			1	1		1	1	1		1	1		2		4
cDNA clones							1	1						1									1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prrx2  paired related homeobox 2   (Synonyms: Prx2, S8)
Results	Reference
1	J:128020 Barbosa AC, Funato N, Chapman S, McKee MD, Richardson JA, Olson EN, Yanagisawa H, Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol. 2007 Oct 1;310(1):154-68
2	J:231885 Beccari L, Yakushiji-Kaminatsui N, Woltering JM, Necsulea A, Lonfat N, Rodriguez-Carballo E, Mascrez B, Yamamoto S, Kuroiwa A, Duboule D, A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. Genes Dev. 2016 May 15;30(10):1172-86
5*	J:71422 Beverdam A, Meijlink F, Expression patterns of group-I aristaless-related genes during craniofacial and limb development. Mech Dev. 2001 Sep;107(1-2):163-7
3*	J:155785 Brinkmeier ML, Davis SW, Carninci P, MacDonald JW, Kawai J, Ghosh D, Hayashizaki Y, Lyons RH, Camper SA, Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches. Genomics. 2009 May;93(5):449-60
1*	J:116770 Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V, Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am J Hum Genet. 2006 Oct;79(4):668-78
4*	J:73653 Chesterman ES, Kern MJ, Comparative analysis of Prx1 and Prx2 expression in mice provides evidence for incomplete compensation. Anat Rec. 2002 Jan 1;266(1):1-4
1	J:171520 Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ, Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011 Apr;49(4):307-25
1*	J:38385 Conway SJ, Henderson DJ, Copp AJ, Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development. 1997 Jan;124(2):505-14
1	J:99734 de Graaff W, Tomotsune D, Oosterveen T, Takihara Y, Koseki H, Deschamps J, Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13362-7
3*	J:12155 de Jong R, Meijlink F, The homeobox gene S8: mesoderm-specific expression in presomite embryos and in cells cultured in vitro and modulation in differentiating pluripotent cells. Dev Biol. 1993 May;157(1):133-46
1	J:79553 Depew MJ, Lufkin T, Rubenstein JL, Specification of jaw subdivisions by Dlx genes. Science. 2002 Oct 11;298(5592):381-5
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
6*	J:286856 Funada K, Yoshizaki K, MIyazaki K, Han X, Yuta T, Tian T, Mizuta K, Fu Y, Iwamoto T, Yamada A, Takahashi I, Fukumoto S, microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development. Sci Rep. 2020 Mar 18;10(1):4918
2*	J:316178 Gamart J, Barozzi I, Laurent F, Reinhardt R, Martins LR, Oberholzer T, Visel A, Zeller R, Zuniga A, SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning. Development. 2021 Dec 1;148(23):dev200182
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:163272 Haugas M, Lillevali K, Hakanen J, Salminen M, Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space. Dev Dyn. 2010 Sep;239(9):2452-69
1	J:90847 Hirota J, Mombaerts P, The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8751-5
5*	J:125749 Hou J, Charters AM, Lee SC, Zhao Y, Wu MK, Jones SJ, Marra MA, Hoodless PA, A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). BMC Dev Biol. 2007;7:92
7	J:309444 Jiang Y, Kong S, He B, Wang B, Wang H, Lu J, Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice. Cell Tissue Res. 2016 Aug;365(2):403-14
2	J:194035 Kan A, Tabin CJ, c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
4	J:44495 Karg H, Burger EH, Lyaruu DM, Bronckers AL, Woltgens JH, Spatiotemporal expression of the homeobox gene S8 during mouse tooth development. Arch Oral Biol. 1997 Sep;42(9):625-31
1*	J:94411 Kelly RG, Jerome-Majewska LA, Papaioannou VE, The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Hum Mol Genet. 2004 Nov 15;13(22):2829-40
11*	J:28661 Leussink B, Brouwer A, el Khattabi M, Poelmann RE, Gittenberger-de Groot AC, Meijlink F, Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain. Mech Dev. 1995 Jul;52(1):51-64
3*	J:51596 Lu MF, Cheng HT, Kern MJ, Potter SS, Tran B, Diekwisch TG, Martin JF, prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development. 1999 Feb;126(3):495-504
3*	J:52212 Lu MF, Cheng HT, Lacy AR, Kern MJ, Argao EA, Potter SS, Olson EN, Martin JF, Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis. Dev Biol. 1999 Jan 1;205(1):145-57
2*	J:135688 Moisan V, Bomgardner D, Tremblay JJ, Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis. BMC Dev Biol. 2008;8:22
1	J:337259 Ocana OH, Coskun H, Minguillon C, Murawala P, Tanaka EM, Galceran J, Munoz-Chapuli R, Nieto MA, A right-handed signalling pathway drives heart looping in vertebrates. Nature. 2017 Sep 6;549(7670):86-90
6*	J:11448 Opstelten DJ, Vogels R, Robert B, Kalkhoven E, Zwartkruis F, de Laaf L, Destree OH, Deschamps J, Lawson KA, Meijlink F, The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech Dev. 1991 Mar;34(1):29-41
1*	J:90465 Ozeki H, Kurihara Y, Tonami K, Watatani S, Kurihara H, Endothelin-1 regulates the dorsoventral branchial arch patterning in mice. Mech Dev. 2004 Apr;121(4):387-95
1	J:264351 Rivera-Reyes R, Kleppa MJ, Kispert A, Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins. PLoS One. 2018;13(8):e0200964
2	J:114449 Robledo RF, Lufkin T, Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus. Genesis. 2006 Sep;44(9):425-37
1*	J:239225 Scott KK, Norris RA, Potter SS, Norrington DW, Baybo MA, Hicklin DM, Kern MJ, GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. DNA Cell Biol. 2003 Feb;22(2):95-105
1	J:182258 Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG, Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
2	J:241567 Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE, Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 Jun 01;144(11):2021-2031
1*	J:48587 ten Berge D, Brouwer A, el Bahi S, Guenet JL, Robert B, Meijlink F, Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm. Dev Biol. 1998 Jul 1;199(1):11-25
6*	J:50488 ten Berge D, Brouwer A, Korving J, Martin JF, Meijlink F, Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs. Development. 1998 Oct;125(19):3831-42
1*	J:71035 ten Berge D, Brouwer A, Korving J, Reijnen MJ, van Raaij EJ, Verbeek F, Gaffield W, Meijlink F, Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development. 2001 Aug;128(15):2929-38
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:79512 Tribioli C, Robledo R, Lufkin T, The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis. Mech Dev. 2002 Oct;118(1-2):161
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:85072 Vitelli F, Viola A, Morishima M, Pramparo T, Baldini A, Lindsay E, TBX1 is required for inner ear morphogenesis. Hum Mol Genet. 2003 Aug 15;12(16):2041-8
1	J:312465 Yin Y, Haller ME, Chadchan SB, Kommagani R, Ma L, Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization. JCI Insight. 2021 Sep 8;6(17)
1	J:183887 Zhang Y, Blackwell EL, McKnight MT, Knutsen GR, Vu WT, Ruest LB, Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2. Dev Dyn. 2012 May;241(5):924-40