Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKAR2A
  • Mouse genes Prkar2a
  • Rat genes Prkar2a
  • Zfish genes prkar2aa,prkar2ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkar2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	Prkar2a	IPI	UniProtKB:P10608	Rat	PMID:20395454|RGD:12907549
Molecular Function	GO:0030552	cAMP binding	Prkar2a	IDA		Rat	PMID:11907174|RGD:2312572
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	PRKAR2A	IDA		Human	PMID:21812984
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	PRKAR2A	IDA		Human	PMID:21812984
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar2a	IDA		Rat	PMID:11907174|RGD:2312572
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar2a	IDA		Rat	PMID:16816331|RGD:2312556
Molecular Function	GO:0042802	identical protein binding	Prkar2a	IPI	RGD:3393	Rat	PMID:17081990|RGD:2312555
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:O75969	Human	PMID:11278869
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P03259-2	Human	PMID:11414803
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P17612,UniProtKB:Q86UN6	Human	PMID:12475942
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q86UN6	Human	PMID:12475942
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P24588	Human	PMID:16642035
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q92667	Human	PMID:16642035
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:O43823	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P15311	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P24588	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q92667	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q99996	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P31323,UniProtKB:P49841,UniProtKB:Q9P0R6	Human	PMID:20007971
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P31323,UniProtKB:Q9P0R6	Human	PMID:20007971
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P24588	Human	PMID:22343722
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P40146	Human	PMID:22976297
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q92667	Human	PMID:24083380
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q92667	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P31323,UniProtKB:Q9P0R6	Human	PMID:25920809
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:P24588	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q92667	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:Q9P0R6	Human	PMID:27484798
Molecular Function	GO:0005515	protein binding	PRKAR2A	IPI	UniProtKB:O43823	Human	PMID:9473338
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:Q8K3I4	Mouse	MGI:MGI:3762420|PMID:17827149
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:Q8NFW9	Mouse	MGI:MGI:3762420|PMID:17827149
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:Q60662	Mouse	MGI:MGI:1328474|PMID:9852104
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:O54931-3	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:D3YVF0	Mouse	MGI:MGI:5447853|PMID:22940692
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	RGD:620833	Rat	PMID:10618500|RGD:631929
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:D4A772|UniProtKB:P84060	Rat	PMID:17610895|RGD:126781731
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:Q5PPI3	Rat	PMID:20007971|RGD:13210529
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	RGD:1303071	Rat	PMID:21177871|RGD:7243101
Molecular Function	GO:0005515	protein binding	Prkar2a	IPI	UniProtKB:Q5VU43-11	Rat	PMID:21569246|RGD:10047194
Molecular Function	GO:0005515	protein binding	prkar2aa	IPI	ZFIN:ZDB-GENE-080123-1	Zfish	PMID:17827149
Molecular Function	GO:0019904	protein domain specific binding	PRKAR2A	IPI	UniProtKB:O43572	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	PRKAR2A	IPI	UniProtKB:P15311	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	PRKAR2A	IPI	UniProtKB:Q68DQ2	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	PRKAR2A	IPI	UniProtKB:Q92558	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	PRKAR2A	IPI	UniProtKB:Q9P0M2	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	PRKAR2A	IPI	UniProtKB:Q9Y6W5	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	Prkar2a	IDA		Rat	PMID:16306226|RGD:2312613
Molecular Function	GO:0019904	protein domain specific binding	Prkar2a	IPI	RGD:1305135	Rat	PMID:17081990|RGD:2312555
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR2A	IPI	UniProtKB:P17612	Human	PMID:17911601
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR2A	IPI	UniProtKB:P17612-1	Human	PMID:21812984
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR2A	IPI	UniProtKB:P17612-2	Human	PMID:21812984
Molecular Function	GO:0044877	protein-containing complex binding	Prkar2a	IDA		Rat	PMID:17081990|RGD:2312555
Molecular Function	GO:0036094	small molecule binding	Prkar2a	IDA		Rat	PMID:21177871|RGD:7243101
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PRKAR2A	IDA		Human	PMID:21423175
Cellular Component	GO:0005930	axoneme	PRKAR2A	IDA		Human	PMID:12475942
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	PRKAR2A	IDA		Human	PMID:12475942
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar2a	IDA		Mouse	PMID:21502359
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar2a	IDA		Rat	PMID:11907174|RGD:2312572
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar2a	IDA		Rat	PMID:16816331|RGD:2312556
Cellular Component	GO:0005813	centrosome	PRKAR2A	IDA		Human	PMID:21399614
Cellular Component	GO:0005737	cytoplasm	PRKAR2A	IDA		Human	PMID:21423175
Cellular Component	GO:0005737	cytoplasm	Prkar2a	IDA		Mouse	PMID:21502359
Cellular Component	GO:0005737	cytoplasm	Prkar2a	IDA		Rat	PMID:18550536|RGD:2312619
Cellular Component	GO:0070062	extracellular exosome	PRKAR2A	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PRKAR2A	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PRKAR2A	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	PRKAR2A	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2a	IDA		Mouse	PMID:15255994
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2a	IMP		Mouse	PMID:15255994
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2a	IDA		Mouse	PMID:24413018
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2a	EXP		Mouse	PMID:24413018
Cellular Component	GO:0016020	membrane	PRKAR2A	HDA		Human	PMID:19946888
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	PRKAR2A	IDA		Human	PMID:21812984
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Prkar2a	IDA		Rat	PMID:18550536|RGD:2312619
Cellular Component	GO:0005886	plasma membrane	PRKAR2A	IDA		Human	PMID:21423175
Cellular Component	GO:0044853	plasma membrane raft	PRKAR2A	IDA		Human	PMID:17911601
Cellular Component	GO:0032991	protein-containing complex	PRKAR2A	IDA		Human	PMID:25097019
Cellular Component	GO:0032991	protein-containing complex	Prkar2a	IDA		Rat	PMID:17081990|RGD:2312555
Cellular Component	GO:0045202	synapse	Prkar2a	IDA		Mouse	PMID:24413018
Cellular Component	GO:0045202	synapse	Prkar2a	EXP		Mouse	PMID:24413018
Cellular Component	GO:0030315	T-tubule	Prkar2a	IDA		Rat	PMID:14569017|RGD:1304018
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Prkar2a	IDA		Mouse	PMID:15255994
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Prkar2a	IMP		Mouse	PMID:15255994
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	PRKAR2A	IDA		Human	PMID:21812984
Biological Process	GO:0045859	regulation of protein kinase activity	Prkar2a	IDA		Rat	PMID:11907174|RGD:2312572
Biological Process	GO:0045859	regulation of protein kinase activity	Prkar2a	IDA		Rat	PMID:16816331|RGD:2312556
Biological Process	GO:0097338	response to clozapine	Prkar2a	IEP		Rat	PMID:11907174|RGD:2312572

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern