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Prkar2a Gene Detail
Summary
  • Symbol
    Prkar2a
  • Name
    protein kinase, cAMP dependent regulatory, type II alpha
  • Synonyms
    1110061A24Rik, RII(alpha)
  • Feature Type
    protein coding gene
  • IDs
    MGI:108025
    NCBI Gene: 19087
  • Gene Overview
    MyGene.info: PRKAR2A
Location & Maps
more
  • Sequence Map
    Chr9:108689314-108750436 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61123 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRKAR2A, protein kinase cAMP-dependent type II regulatory subunit alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKAR2A, protein kinase cAMP-dependent type II regulatory subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PKR2, PRKAR2
  • Links
    NCBI Gene ID: 5576
    neXtProt AC: NX_P13861

  • Chr Location
    3p21.3-p21.2; chr3:48744601-48847837 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
  • All Mutations and Alleles
    60
  • Gene trapped
    59
  • Targeted
    1
  • Incidental Mutations
Homozygous null mice are viable and appear healthy. They have normal growth and no deficits in locomotor activity, muscle strength, or exploratory behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050671 VEGA Gene Model | MGI Sequence Detail 61123 C57BL/6J ±  kb
transcript OTTMUST00000128449 VEGA | MGI Sequence Detail 4965 Not Applicable  
polypeptide OTTMUSP00000069099 VEGA | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    108 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 23
    Genomic 3
    cDNA 18
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-37061, MGI:1913460, MGI:2143017, MGI:2143127
References
more
  • Summaries
    All 68
    Developmental Gene Expression 13
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:36741 Scott JD, et al., The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5192-6
  • Latest
    J:228948 Deak VA, et al., The A-kinase Anchoring Protein GSKIP Regulates GSK3beta Activity and Controls Palatal Shelf Fusion in Mice. J Biol Chem. 2016 Jan 8;291(2):681-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory