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Prkar2a Gene Detail
Summary
  • Symbol
    Prkar2a
  • Name
    protein kinase, cAMP dependent regulatory, type II alpha
  • Synonyms
    1110061A24Rik, RII(alpha)
  • Feature Type
    protein coding gene
  • IDs
    MGI:108025
    NCBI Gene: 19087
  • Gene Overview
    MyGene.info: PRKAR2A
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108692143-108749512 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108025
protein coding gene Chr9:108689314-108750436 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035311
protein coding gene Chr9:110668680-110738445 (+)
A/J MGP_AJ_G0035290
protein coding gene Chr9:106611138-106672930 (+)
AKR/J MGP_AKRJ_G0035222
protein coding gene Chr9:109286381-109352927 (+)
BALB/cJ MGP_BALBcJ_G0035284
protein coding gene Chr9:106306743-106369084 (+)
C3H/HeJ MGP_C3HHeJ_G0034994
protein coding gene Chr9:109686121-109750246 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035804
protein coding gene Chr9:113692188-113756529 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032702
protein coding gene Chr9:104032520-104086699 (+)
CAST/EiJ MGP_CASTEiJ_G0034305
protein coding gene Chr9:109643631-109713661 (+)
CBA/J MGP_CBAJ_G0034962
protein coding gene Chr9:117706005-117779590 (+)
DBA/2J MGP_DBA2J_G0035123
protein coding gene Chr9:106067505-106128858 (+)
FVB/NJ MGP_FVBNJ_G0035071
protein coding gene Chr9:104834016-104895745 (+)
LP/J MGP_LPJ_G0035199
protein coding gene Chr9:110860897-110927330 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035110
protein coding gene Chr9:119265521-119332166 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035825
protein coding gene Chr9:109559604-109625005 (+)
PWK/PhJ MGP_PWKPhJ_G0034012
protein coding gene Chr9:106396548-106459854 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033847
protein coding gene Chr9:109630062-109693102 (+)
WSB/EiJ MGP_WSBEiJ_G0034426
protein coding gene Chr9:109448280-109518606 (+)



Homology
more
  • Human Ortholog
    PRKAR2A, protein kinase cAMP-dependent type II regulatory subunit alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKAR2A, protein kinase cAMP-dependent type II regulatory subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PKR2, PRKAR2
  • Links
    NCBI Gene ID: 5576
    neXtProt AC: NX_P13861
    UniProt: P13861

  • Chr Location
    3p21.31; chr3:48744601-48847850 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Homozygous null mice are viable and appear healthy. They have normal growth and no deficits in locomotor activity, muscle strength, or exploratory behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19087 NCBI Gene Model | MGI Sequence Detail 57370 C57BL/6J ±  kb
transcript NM_008924 RefSeq | MGI Sequence Detail 4041 C57BL/6  
polypeptide P12367 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 24
    Genomic 3
    cDNA 19
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-37061, MGI:1913460, MGI:2143017, MGI:2143127
References
more
  • Summaries
    All 73
    Developmental Gene Expression 13
    Gene Ontology 12
    Phenotypes 12
  • Earliest
    J:36741 Scott JD, et al., The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5192-6
  • Latest
    J:237274 Kong D, et al., PKA regulatory IIalpha subunit is essential for PGD2-mediated resolution of inflammation. J Exp Med. 2016 Sep 19;213(10):2209-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory