Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDX6
  • Mouse genes Prdx6
  • Rat genes Prdx6
  • Zfish genes prdx6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdx6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	PRDX6	IDA		Human	PMID:26830860
Molecular Function	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	Prdx6	IMP		Mouse	MGI:MGI:5771599|PMID:26830860
Molecular Function	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	Prdx6	IDA		Rat	PMID:26830860|RGD:11571872
Molecular Function	GO:0045296	cadherin binding	PRDX6	HDA		Human	PMID:25468996
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	PRDX6	IMP		Human	PMID:10893423
Molecular Function	GO:0004602	glutathione peroxidase activity	PRDX6	IMP		Human	PMID:10893423
Molecular Function	GO:0004602	glutathione peroxidase activity	Prdx6	IDA		Rat	PMID:8641418|RGD:729495
Molecular Function	GO:0042802	identical protein binding	PRDX6	IMP		Human	PMID:9587003
Molecular Function	GO:0004601	peroxidase activity	Prdx6	IMP	MGI:MGI:2668338	Mouse	PMID:12732627
Molecular Function	GO:0004623	phospholipase A2 activity	PRDX6	IDA		Human	PMID:26830860
Molecular Function	GO:0004623	phospholipase A2 activity	Prdx6	IMP		Mouse	MGI:MGI:5771599|PMID:26830860
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:Q8IWL8	Human	PMID:16186110
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P27695	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P12004	Human	PMID:20849852
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P29991:PRO_0000308465	Human	PMID:21911577
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P12004	Human	PMID:26030842
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P09622	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P21796	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:Q7KZN9	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:P48556	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRDX6	IPI	UniProtKB:Q9NP61	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Prdx6	IPI	UniProtKB:O70145	Mouse	MGI:MGI:5494778|PMID:23401562
Molecular Function	GO:0005515	protein binding	Prdx6	IPI	RGD:2617	Rat	PMID:17877381|RGD:2302074
Molecular Function	GO:0005515	protein binding	Prdx6	IPI	UniProtKB:P62259	Rat	PMID:21346153|RGD:8554151
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PRDX6	IPI	UniProtKB:O60260	Human	PMID:19725078
Cellular Component	GO:0005737	cytoplasm	PRDX6	IDA		Human	PMID:16186110
Cellular Component	GO:0005737	cytoplasm	PRDX6	IDA		Human	PMID:19188445
Cellular Component	GO:0005737	cytoplasm	PRDX6	IDA		Human	PMID:25468996
Cellular Component	GO:0005829	cytosol	Prdx6	IDA		Mouse	PMID:12732627
Cellular Component	GO:0070062	extracellular exosome	PRDX6	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PRDX6	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PRDX6	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	PRDX6	HDA		Human	PMID:23580065
Cellular Component	GO:0016020	membrane	PRDX6	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Prdx6	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	PRDX6	IDA		Human	PMID:16186110
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PRDX6	IDA		Human	PMID:16186110
Biological Process	GO:0032060	bleb assembly	Prdx6	IMP		Mouse	PMID:17135244
Biological Process	GO:0098869	cellular oxidant detoxification	PRDX6	IMP		Human	PMID:10893423
Biological Process	GO:0046475	glycerophospholipid catabolic process	PRDX6	IMP		Human	PMID:10893423
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Prdx6	IDA		Rat	PMID:8641418|RGD:729495
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	PRDX6	IGI	UniProtKB:Q8IWL8	Human	PMID:16186110
Biological Process	GO:0006979	response to oxidative stress	PRDX6	IMP		Human	PMID:10893423
Biological Process	GO:0000302	response to reactive oxygen species	Prdx6	IMP	MGI:MGI:2668338	Mouse	PMID:12732627

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern