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Prdx6 Gene Detail
Summary
  • Symbol
    Prdx6
  • Name
    peroxiredoxin 6
  • Synonyms
    1-cysPrx, 1-Cys Prx, 9430088D19Rik, acidic calcium-independent phospholipase A2, aiPLA2, Aop2, Brp-12, CC26, CP-3, GPx, Ltw4, Ltw-4, Lvtw-4, NSGP
  • Feature Type
    protein coding gene
  • IDs
    MGI:894320
    NCBI Gene: 11758
  • Gene Overview
    MyGene.info: PRDX6
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161240112-161251210 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894320
protein coding gene Chr1:161240112-161251219 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016651
protein coding gene Chr1:166502906-166532802 (-)
A/J MGP_AJ_G0016632
protein coding gene Chr1:159725692-159736799 (-)
AKR/J MGP_AKRJ_G0016598
protein coding gene Chr1:164594241-164605348 (-)
BALB/cJ MGP_BALBcJ_G0016593
protein coding gene Chr1:160276354-160287482 (-)
C3H/HeJ MGP_C3HHeJ_G0016417
protein coding gene Chr1:164812074-164823211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017054
protein coding gene Chr1:172154466-172165568 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014763
protein coding gene Chr1:151845942-151857326 (-)
CAST/EiJ MGP_CASTEiJ_G0015997
protein coding gene Chr1:164419210-164430310 (-)
CBA/J MGP_CBAJ_G0016392
protein coding gene Chr1:178248665-178259811 (-)
DBA/2J MGP_DBA2J_G0016498
protein coding gene Chr1:158706486-158718066 (-)
FVB/NJ MGP_FVBNJ_G0016496
protein coding gene Chr1:157112166-157123273 (-)
LP/J MGP_LPJ_G0016569
protein coding gene Chr1:167594779-167609337 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016521
protein coding gene Chr1:185806135-185817242 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017090
protein coding gene Chr1:164420919-164432022 (-)
PWK/PhJ MGP_PWKPhJ_G0015783
protein coding gene Chr1:157865179-157876300 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015570
protein coding gene Chr1:163318056-163329162 (-)
WSB/EiJ MGP_WSBEiJ_G0016059
protein coding gene Chr1:164604861-164615990 (-)



Homology
more
  • Human Ortholog
    PRDX6, peroxiredoxin 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRDX6, peroxiredoxin 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1-Cys, aiPLA2, AOP2, HEL-S-128m, NSGPx, p29, PRX
  • Links
    NCBI Gene ID: 9588
    neXtProt AC: NX_P30041
    UniProt: P30041

  • Chr Location
    1q25.1; chr1:173477347-173488807 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3606
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRDX6
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 5 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene show no macroscopic or microscopic abnormalities. However, they have an increased susceptibility to oxidative stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11758 NCBI Gene Model | MGI Sequence Detail 11099 C57BL/6J ±  kb
    transcript NM_001303408 RefSeq | MGI Sequence Detail 2489 C57BL/6  
    polypeptide O08709 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 404
      Genomic 4
      cDNA 397
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11921, MGD-MRK-11926, MGD-MRK-11944, MGD-MRK-1637, MGI:2444784, MGI:3035058, MGI:96849
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 41
    • Earliest
      J:6130 Elliott RW, Use of two-dimensional electrophoresis to identify and map new mouse genes. Genetics. 1979 Feb;91(2):295-308
    • Latest
      J:273236 Vazquez-Medina JP, et al., Genetic inactivation of the phospholipase A2 activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L656-L668

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory