About   Help   FAQ
Prdx6
Gene Detail
 Symbol
Name
ID
Prdx6
peroxiredoxin 6
MGI:894320
Synonyms 1-cysPrx, 1-Cys Prx, 9430088D19Rik, acidic calcium-independent phospholipase A2, aiPLA2, Aop2, Brp-12, CC26, CP-3, GPx, Ltw4, Ltw-4, Lvtw-4, NSGP
Feature Type protein coding gene
Genetic Map
Chromosome 1
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr1:161240112-161251219 bp, - strand
From VEGA annotation of GRCm38

  11108 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: AHPC
Gene Tree: Prdx6

Human
homologs
Human Homolog PRDX6, peroxiredoxin 6
NCBI Gene ID 9588
neXtProt AC  NX_P30041
Human Synonyms  1-Cys, aiPLA2, AOP2, HEL-S-128m, NSGPx, p29, PRX
Human Chr (Location)  1q25.1; chr1:173477347-173488807 (+)  GRCh38
Alleles
and
phenotypes
All alleles(49) : Gene trapped(44) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene show no macroscopic or microscopic abnormalities. However, they have an increased susceptibility to oxidative stress.
 
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process bleb assembly, hydrogen peroxide catabolic process, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function 1-oxa-2-oxocycloheptane lactonase activity, 3,4-dihydrocoumarin hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (288)    Tissues (130)    Images (35)
Theiler Stages: 11, 13, 15, 17, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 272
Northern blot 14
Western blot 2
cDNA source data(396)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(403) Genomic(4) cDNA(396) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016463 (Evidence)
Ensembl Gene ModelENSMUSG00000026701 (Evidence)
Entrez Gene11758 (Evidence)
UniGene186185
DFCITC1573936, TC1589460, TC1597770
DoTSDT.101257763, DT.101710019, DT.110890045, DT.522575, DT.60118218, DT.99863902
NIA Mouse Gene IndexU021957
EC3.1.1.-, 1.11.1.15, 1.11.1.9
Consensus CDS ProjectCCDS15415.1
International Mouse Knockout Project StatusPrdx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016463 VEGA Gene Model | MGI Sequence Detail 11108 C57BL/6J ±  kb
transcript OTTMUST00000039666 VEGA | MGI Sequence Detail 2387 Not Applicable 
polypeptide OTTMUSP00000017703 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(4) UniProt(6)
Polymorphisms PCR(3) : SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
InterPro IPR024706 Peroxiredoxin, AhpC-type
InterPro IPR019479 Peroxiredoxin, C-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000013196 peroxiredoxin-6
References (Earliest) J:13782 Elliott RW, New variants among mouse liver soluble proteins. Mouse News Lett. 1978;59:59
(Latest) J:198347 Rolfs F, et al., Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis. Cancer Res. 2013 Jun 1;73(11):3460-9
All references(93)
Other
accession IDs
MGD-MRK-11921, MGD-MRK-11926, MGD-MRK-11944, MGD-MRK-1637, MGI:2444784, MGI:3035058, MGI:96849

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory