Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDM5
  • Mouse genes Prdm5
  • Rat genes Prdm5
  • Zfish genes prdm5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdm5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	PRDM5	IDA		Human	PMID:17636019
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PRDM5	IDA		Human	PMID:17636019
Molecular Function	GO:0005515	protein binding	PRDM5	IPI	UniProtKB:Q13547	Human	PMID:17636019
Molecular Function	GO:0005515	protein binding	PRDM5	IPI	UniProtKB:Q96KQ7	Human	PMID:17636019
Molecular Function	GO:0005515	protein binding	PRDM5	IPI	UniProtKB:Q99684	Human	PMID:17636019
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	PRDM5	IDA		Human	PMID:17636019
Molecular Function	GO:0043565	sequence-specific DNA binding	PRDM5	IDA		Human	PMID:17636019
Molecular Function	GO:0000976	transcription cis-regulatory region binding	PRDM5	IDA		Human	PMID:17636019
Cellular Component	GO:0016604	nuclear body	PRDM5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	PRDM5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PRDM5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRDM5	IDA		Human	PMID:17636019
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Prdm5	IEP		Mouse	PMID:20439489
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	prdm5	IMP	ZFIN:ZDB-GENO-120403-8	Zfish	PMID:23109401
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	prdm5	IGI	ZFIN:ZDB-GENO-131209-1	Zfish	PMID:23109401
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	prdm5	IGI	ZFIN:ZDB-GENO-131209-1	Zfish	PMID:23109401
Biological Process	GO:0000278	mitotic cell cycle	PRDM5	IMP		Human	PMID:17636019
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PRDM5	IDA		Human	PMID:17636019
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PRDM5	IMP		Human	PMID:21664999
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PRDM5	IDA		Human	PMID:17636019
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PRDM5	IMP		Human	PMID:21664999
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	prdm5	IMP	ZFIN:ZDB-MRPHLNO-090429-1,ZFIN:ZDB-MRPHLNO-090429-2	Zfish	PMID:19169355
Biological Process	GO:0006355	regulation of DNA-templated transcription	prdm5	IMP	ZFIN:ZDB-MRPHLNO-090429-1,ZFIN:ZDB-MRPHLNO-090429-2	Zfish	PMID:19169355
Biological Process	GO:1903053	regulation of extracellular matrix organization	PRDM5	IMP		Human	PMID:21664999
Biological Process	GO:2000050	regulation of non-canonical Wnt signaling pathway	prdm5	IMP	ZFIN:ZDB-MRPHLNO-090429-1,ZFIN:ZDB-MRPHLNO-090429-2	Zfish	PMID:19169355

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern