About   Help   FAQ
Prdm5
Gene Detail
Symbol

Name
ID
Prdm5
PR domain containing 5
MGI:1918029
Synonyms
4432417F03Rik, 6530401I24Rik, E130112L17Rik, PFM2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
30.32 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:65778988-65936373 bp, + strand
From VEGA annotation of GRCm38

  157386 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRDM5
Protein SuperFamily: PR-domain zinc finger protein PRDM5
Gene Tree: Prdm5

Human
homologs
PRDM5, PR domain containing 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11107
neXtProt AC: NX_Q9NQX1

Human Synonyms: BCS2, PFM2

Human Chr (Location): 4q25-q26; chr4:120684928-120922866 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRDM5

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(33)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a hypomorphic allele display delayed bone ossification with reduced collagen fibril formation, total bone area, bone mineral content and bone mineral density.
 
Phenotype Images(1)
Interactions
Prdm5 interacts with 60 markers (Mir27a, Mir27b, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process chromatin modification, histone deacetylation, ...
Component nucleus
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (134)    Tissues (76)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 88
RT-PCR 46
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PRDM5 ZFIN prdm5    NEW 
Molecular
reagents
All nucleic(33) cDNA(30) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000036961 (Evidence)
Ensembl Gene Model ENSMUSG00000029913 (Evidence)
Entrez Gene 70779 (Evidence)
UniGene 263355
DFCI TC1582687, TC1595806, TC1606353, TC1588199, TC1594500
DoTS DT.97384451, DT.94172366, DT.91325909, DT.528468
NIA Mouse Gene Index U006968
EC 2.1.1.-
Consensus CDS Project CCDS20208.1
International Mouse Phenotyping Consortium Status Prdm5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036961 VEGA Gene Model | MGI Sequence Detail 157386 C57BL/6J ±  kb
transcript OTTMUST00000094991 VEGA | MGI Sequence Detail 2152 Not Applicable 
polypeptide OTTMUSP00000052972 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(15) UniProt(5)
Polymorphisms
SNPs within 2kb(1257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017125 PR-domain zinc finger protein PRDM5
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
InterPro IPR022755 Zinc finger, double-stranded RNA binding
Protein Ontology PR:000013188 PR domain zinc finger protein 5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212619 Galli GG, et al., Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression. Oncogene. 2014 Jun 19;33(25):3342-50
All references(44)
Other
accession IDs
MGI:1353658, MGI:1923493, MGI:1925253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory