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Prdm5
Gene Detail
 Symbol
Name
ID
Prdm5
PR domain containing 5
MGI:1918029
Synonyms 4432417F03Rik, 6530401I24Rik, E130112L17Rik, PFM2
Feature Type protein coding gene
Genetic Map
Chromosome 6
30.32 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:65778988-65936373 bp, + strand
From VEGA annotation of GRCm38

  157386 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: PR-domain zinc finger protein PRDM5
Gene Tree: Prdm5

Human
homologs
Human Homolog PRDM5, PR domain containing 5
NCBI Gene ID 11107
neXtProt AC  NX_Q9NQX1
Human Synonyms  BCS2, PFM2
Human Chr (Location)  4q25-q26; chr4:120691915-120922858 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRDM5
Alleles
and
phenotypes
All alleles(33) : Gene trapped(33)
 
Mice homozygous for a hypomorphic allele display delayed bone ossification with reduced collagen fibril formation, total bone area, bone mineral content and bone mineral density.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process chromatin modification, histone deacetylation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (141)    Tissues (80)    Images (11)
Theiler Stages: 2, 3, 4, 5, 16, 17, 19, 20, 21, 23, 28
Assay TypeResults
RNA in situ 88
RT-PCR 53
cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(33) cDNA(30) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000036961 (Evidence)
Ensembl Gene ModelENSMUSG00000029913 (Evidence)
Entrez Gene70779 (Evidence)
UniGene263355
DFCITC1582687, TC1588199, TC1594500, TC1595806, TC1606353
DoTSDT.528468, DT.91325909, DT.94172366, DT.97384451
NIA Mouse Gene IndexU006968
EC2.1.1.-
Consensus CDS ProjectCCDS20208.1
International Mouse Knockout Project StatusPrdm5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036961 VEGA Gene Model | MGI Sequence Detail 157386 C57BL/6J ±  kb
transcript OTTMUST00000094991 VEGA | MGI Sequence Detail 2152 Not Applicable 
polypeptide OTTMUSP00000052972 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(15) UniProt(5)
Polymorphisms SNPs within 2kb(1257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017125 PR-domain zinc finger protein PRDM5
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
InterPro IPR022755 Zinc finger, double-stranded RNA binding
Protein Ontology PR:000013188 PR domain zinc finger protein 5
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185118 Galli GG, et al., Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone. PLoS Genet. 2012 May;8(5):e1002711
All references(42)
Other
accession IDs
MGI:1353658, MGI:1923493, MGI:1925253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory