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Prdm5 Gene Detail
Summary
  • Symbol
    Prdm5
  • Name
    PR domain containing 5
  • Synonyms
    4432417F03Rik, 6530401I24Rik, E130112L17Rik, PFM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918029
    NCBI Gene: 70779
Location & Maps
more
  • Sequence Map
    Chr6:65778988-65937010 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      158023 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRDM5, PR domain 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRDM5, PR domain 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCS2, PFM2
  • Links
    NCBI Gene ID: 11107
    neXtProt AC: NX_Q9NQX1

  • Chr Location
    4q27; chr4:120684928-120922866 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PRDM5 associations

Human Disease Mouse Models
       Brittle Cornea Syndrome 2; BCS2   OMIM: 614170
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele display delayed bone ossification with reduced collagen fibril formation, total bone area, bone mineral content and bone mineral density.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036961 VEGA Gene Model | MGI Sequence Detail 158023 C57BL/6J ±  kb
transcript OTTMUST00000094991 VEGA | MGI Sequence Detail 2155 Not Applicable  
polypeptide OTTMUSP00000052972 VEGA | MGI Sequence Detail 599 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1270 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 33
    cDNA 30
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGI:1353658, MGI:1923493, MGI:1925253
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:212619 Galli GG, et al., Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression. Oncogene. 2014 Jun 19;33(25):3342-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory