Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLCB2
  • Mouse genes Plcb2
  • Rat genes Plcb2
  • Zfish genes plcb2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plcb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	Plcb2	IDA		Rat	PMID:9931017|RGD:1599908
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCB2	IMP		Human	PMID:8519600
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCB2	IDA		Human	PMID:9188725
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcb2	IMP		Rat	PMID:9860142|RGD:729588
Molecular Function	GO:0004629	phospholipase C activity	Plcb2	IMP		Rat	PMID:9860142|RGD:729588
Molecular Function	GO:0005543	phospholipid binding	Plcb2	IDA		Rat	PMID:9931017|RGD:1599908
Molecular Function	GO:0005515	protein binding	PLCB2	IPI	UniProtKB:Q9UBT7	Human	PMID:21115837
Cellular Component	GO:0005737	cytoplasm	Plcb2	IDA		Mouse	PMID:23010799
Cellular Component	GO:0005737	cytoplasm	Plcb2	IDA		Mouse	PMID:21606356
Cellular Component	GO:0005829	cytosol	Plcb2	IDA		Rat	PMID:12176394|RGD:2314510
Cellular Component	GO:0031680	G-protein beta/gamma-subunit complex	Plcb2	IDA		Rat	PMID:9931017|RGD:1599908
Cellular Component	GO:0005794	Golgi apparatus	Plcb2	IDA		Rat	PMID:10070498|RGD:1599907
Cellular Component	GO:0098992	neuronal dense core vesicle	Plcb2	IDA		Mouse	PMID:21321602
Cellular Component	GO:0005886	plasma membrane	Plcb2	IDA		Rat	PMID:12176394|RGD:2314510
Biological Process	GO:0036302	atrioventricular canal development	plcb2	IMP	ZFIN:ZDB-MRPHLNO-210329-3	Zfish	PMID:32859249
Biological Process	GO:0036302	atrioventricular canal development	plcb2	IMP	ZFIN:ZDB-MRPHLNO-210329-6	Zfish	PMID:32859249
Biological Process	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	Plcb2	IDA		Rat	PMID:9860142|RGD:729588
Biological Process	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	Plcb2	IMP		Rat	PMID:9860142|RGD:729588
Biological Process	GO:0061371	determination of heart left/right asymmetry	plcb2	IMP	ZFIN:ZDB-MRPHLNO-210329-3	Zfish	PMID:32859249
Biological Process	GO:0061371	determination of heart left/right asymmetry	plcb2	IMP	ZFIN:ZDB-MRPHLNO-210329-6	Zfish	PMID:32859249
Biological Process	GO:0046488	phosphatidylinositol metabolic process	PLCB2	IDA		Human	PMID:9188725
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Plcb2	IDA		Rat	PMID:9860142|RGD:729588
Biological Process	GO:0050913	sensory perception of bitter taste	Plcb2	IMP	MGI:MGI:2653348	Mouse	PMID:15759003

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern