About   Help   FAQ
Plcb2 Gene Detail
Summary
  • Symbol
    Plcb2
  • Name
    phospholipase C, beta 2
  • Synonyms
    B230205M18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107465
    NCBI Gene: 18796
  • Gene Overview
    MyGene.info: PLCB2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118707517-118728438 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.43 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107465
protein coding gene Chr2:118705003-118728662 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026320
protein coding gene Chr2:121404576-121425391 (-)
A/J MGP_AJ_G0026281
protein coding gene Chr2:116482692-116503540 (-)
AKR/J MGP_AKRJ_G0026260
protein coding gene Chr2:119745648-119766505 (-)
BALB/cJ MGP_BALBcJ_G0026294
protein coding gene Chr2:116737104-116760539 (-)
C3H/HeJ MGP_C3HHeJ_G0026040
protein coding gene Chr2:120210300-120231881 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026741
protein coding gene Chr2:125413831-125434747 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024121
protein coding gene Chr2:111526956-111547688 (-)
CAST/EiJ MGP_CASTEiJ_G0025502
protein coding gene Chr2:120517250-120539835 (-)
CBA/J MGP_CBAJ_G0026016
protein coding gene Chr2:129837863-129858669 (-)
DBA/2J MGP_DBA2J_G0026155
protein coding gene Chr2:115900459-115923513 (-)
FVB/NJ MGP_FVBNJ_G0026117
protein coding gene Chr2:114729511-114750548 (-)
LP/J MGP_LPJ_G0026256
protein coding gene Chr2:121735786-121756576 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026136
protein coding gene Chr2:134206377-134228633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026796
protein coding gene Chr2:119870412-119891204 (-)
PWK/PhJ MGP_PWKPhJ_G0025238
protein coding gene Chr2:115455386-115474634 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025037
protein coding gene Chr2:119037025-119057946 (-)
WSB/EiJ MGP_WSBEiJ_G0025571
protein coding gene Chr2:120686187-120708061 (-)



Homology
more
  • Human Ortholog
    PLCB2, phospholipase C beta 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLCB2, phospholipase C beta 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PLC-beta-2
  • Links
    NCBI Gene ID: 5330
    neXtProt AC: NX_Q00722
    UniProt: Q00722

  • Chr Location
    15q15.1; chr15:40285496-40307973 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice showed an increased sensitivity to both bacterial and viral infections and exhibited abnormal taste perception in which sweet, umami, and bitter stimuli could not be sensed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040061 Ensembl Gene Model | MGI Sequence Detail 20922 C57BL/6J ±  kb
    transcript ENSMUST00000102524 Ensembl | MGI Sequence Detail 5145 Not Applicable  
    polypeptide ENSMUSP00000099583 Ensembl | MGI Sequence Detail 1181 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012829 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    • EC
    • InterPro Domains
      IPR028403 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR014815 Phospholipase C-beta, C-terminal domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR037862 PLC-beta, PH domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35937, MGI:2139001, MGI:3036256
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:259982 Weng PL, et al., Ascl3 transcription factor marks a distinct progenitor lineage for non-neuronal support cells in the olfactory epithelium. Sci Rep. 2016 Dec 2;6:38199

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory