Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLA2R1
  • Mouse genes Pla2r1
  • Rat genes Pla2r1
  • Zfish genes pla2r1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pla2r1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043274	phospholipase binding	Pla2r1	IPI	UniProtKB:P00592|UniProtKB:P97391	Mouse	MGI:MGI:5297792|PMID:11830583
Molecular Function	GO:0043274	phospholipase binding	Pla2r1	IPI	UniProtKB:P00592	Mouse	MGI:MGI:68989|PMID:7925459
Cellular Component	GO:0009986	cell surface	PLA2R1	IDA		Human	PMID:15611272
Cellular Component	GO:0005576	extracellular region	Pla2r1	IDA		Mouse	MGI:MGI:5297792|PMID:11830583
Cellular Component	GO:0005886	plasma membrane	PLA2R1	IDA		Human	PMID:12225974
Cellular Component	GO:0043235	receptor complex	PLA2R1	IDA		Human	PMID:23382219
Biological Process	GO:1900139	negative regulation of arachidonic acid secretion	Pla2r1	IDA		Mouse	MGI:MGI:5297792|PMID:11830583
Biological Process	GO:1900138	negative regulation of phospholipase A2 activity	Pla2r1	IDA		Mouse	MGI:MGI:5297792|PMID:11830583
Biological Process	GO:0090403	oxidative stress-induced premature senescence	PLA2R1	IMP		Human	PMID:19197340
Biological Process	GO:0090238	positive regulation of arachidonic acid secretion	Pla2r1	IDA		Mouse	MGI:MGI:5297793|PMID:10946309
Biological Process	GO:0001819	positive regulation of cytokine production	PLA2R1	IMP		Human	PMID:15611272
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	PLA2R1	IMP		Human	PMID:19197340
Biological Process	GO:1904635	positive regulation of podocyte apoptotic process	PLA2R1	IMP		Human	PMID:25335547
Biological Process	GO:0072593	reactive oxygen species metabolic process	PLA2R1	IDA		Human	PMID:19197340
Biological Process	GO:0006898	receptor-mediated endocytosis	Pla2r1	IDA		Mouse	MGI:MGI:68989|PMID:7925459
Biological Process	GO:0090399	replicative senescence	PLA2R1	IMP		Human	PMID:19197340

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern