Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PFN1
  • Mouse genes Pfn1
  • Rat genes Pfn1
  • Zfish genes pfn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pfn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	PFN1	IPI	UniProtKB:P68135	Human	PMID:17914456
Molecular Function	GO:0003779	actin binding	PFN1	IPI	UniProtKB:P68135	Human	PMID:7758455
Molecular Function	GO:0003785	actin monomer binding	PFN1	IDA		Human	PMID:18573880
Molecular Function	GO:0000774	adenyl-nucleotide exchange factor activity	PFN1	IDA		Human	PMID:7758455
Molecular Function	GO:0045296	cadherin binding	PFN1	HDA		Human	PMID:25468996
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PFN1	IDA		Human	PMID:7758455
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Pfn1	IDA		Rat	PMID:16741017|RGD:2324852
Molecular Function	GO:0001784	phosphotyrosine residue binding	PFN1	IPI	UniProtKB:Q14247	Human	PMID:24700464
Molecular Function	GO:0070064	proline-rich region binding	PFN1	IPI	UniProtKB:P50552	Human	PMID:17914456
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P68135	Human	PMID:16531231
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P68135	Human	PMID:17470807
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P42858	Human	PMID:18573880
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P07830	Human	PMID:18689676
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P60709	Human	PMID:19000816
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P60709	Human	PMID:19338310
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P50552	Human	PMID:23153535
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:P70429	Human	PMID:23153535
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:O08816	Human	PMID:9822597
Molecular Function	GO:0005515	protein binding	PFN1	IPI	UniProtKB:Q92558	Human	PMID:9843499
Molecular Function	GO:0005515	protein binding	Pfn1	IPI	UniProtKB:P03372	Mouse	MGI:MGI:5514125|PMID:23576398
Molecular Function	GO:0005515	protein binding	Pfn1	IPI	PR:Q8R4U1	Mouse	PMID:15615774
Molecular Function	GO:0005515	protein binding	Pfn1	IPI	PR:Q0QWG9	Mouse	PMID:11826110
Molecular Function	GO:0005515	protein binding	Pfn1	IPI	RGD:69194	Rat	PMID:12967995|RGD:2324853
Molecular Function	GO:0003723	RNA binding	PFN1	HDA		Human	PMID:22681889
Molecular Function	GO:0005102	signaling receptor binding	Pfn1	IDA		Rat	PMID:10966486|RGD:2324858
Molecular Function	GO:0031267	small GTPase binding	Pfn1	IPI	UniProtKB:P17081	Mouse	MGI:MGI:3843447|PMID:10445846
Cellular Component	GO:0072562	blood microparticle	PFN1	HDA		Human	PMID:22516433
Cellular Component	GO:0005938	cell cortex	PFN1	IDA		Human	PMID:24700464
Cellular Component	GO:0005737	cytoplasm	PFN1	IDA		Human	PMID:24700464
Cellular Component	GO:0005737	cytoplasm	Pfn1	IDA		Mouse	PMID:11274401
Cellular Component	GO:0005737	cytoplasm	Pfn1	IDA		Rat	PMID:12967995|RGD:2324853
Cellular Component	GO:0070062	extracellular exosome	PFN1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PFN1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PFN1	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	PFN1	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Pfn1	IMP		Mouse	PMID:26951674
Cellular Component	GO:0098978	glutamatergic synapse	Pfn1	IDA		Mouse	PMID:26951674
Cellular Component	GO:0016020	membrane	PFN1	HDA		Human	PMID:19946888
Cellular Component	GO:0043005	neuron projection	Pfn1	IDA		Rat	PMID:8106880|RGD:2324862
Cellular Component	GO:0005634	nucleus	PFN1	IDA		Human	PMID:24700464
Cellular Component	GO:0005634	nucleus	Pfn1	IDA		Mouse	PMID:15615774
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Pfn1	IDA		Rat	PMID:15654839|RGD:13702446
Cellular Component	GO:0098794	postsynapse	Pfn1	IDA		Rat	PMID:15654839|RGD:13702446
Cellular Component	GO:0098793	presynapse	Pfn1	IDA		Rat	PMID:15654839|RGD:13702446
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Pfn1	IDA		Rat	PMID:15654839|RGD:13702446
Cellular Component	GO:0045202	synapse	Pfn1	IDA		Rat	PMID:12967995|RGD:2324853
Biological Process	GO:0071363	cellular response to growth factor stimulus	Pfn1	IEP		Rat	PMID:10703666|RGD:2324859
Biological Process	GO:0060027	convergent extension involved in gastrulation	pfn1	IGI	ZFIN:ZDB-MRPHLNO-090115-2,ZFIN:ZDB-MRPHLNO-090115-3	Zfish	PMID:18941507
Biological Process	GO:0060027	convergent extension involved in gastrulation	pfn1	IMP	ZFIN:ZDB-MRPHLNO-090115-3	Zfish	PMID:18941507
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	pfn1	IMP	ZFIN:ZDB-MRPHLNO-090115-3	Zfish	PMID:18941507
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	pfn1	IGI	ZFIN:ZDB-MRPHLNO-090115-2,ZFIN:ZDB-MRPHLNO-090115-3	Zfish	PMID:18941507
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	Pfn1	IDA		Mouse	PMID:26951674
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	Pfn1	IMP		Mouse	PMID:26951674
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pfn1	IDA		Mouse	PMID:26951674
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pfn1	IMP		Mouse	PMID:26951674
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	PFN1	IMP		Human	PMID:23153535
Biological Process	GO:0030837	negative regulation of actin filament polymerization	PFN1	IDA		Human	PMID:7758455
Biological Process	GO:0051497	negative regulation of stress fiber assembly	PFN1	IMP		Human	PMID:23153535
Biological Process	GO:0001843	neural tube closure	Pfn1	IGI	MGI:MGI:108360	Mouse	PMID:10069337
Biological Process	GO:0030838	positive regulation of actin filament polymerization	PFN1	IGI	UniProtKB:P35080	Human	PMID:23153535
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	PFN1	IDA		Human	PMID:7758455
Biological Process	GO:0051054	positive regulation of DNA metabolic process	Pfn1	IDA		Rat	PMID:10966486|RGD:2324858
Biological Process	GO:0010634	positive regulation of epithelial cell migration	PFN1	IMP		Human	PMID:23153535
Biological Process	GO:1900029	positive regulation of ruffle assembly	PFN1	IMP		Human	PMID:23153535
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Pfn1	IMP		Rat	PMID:12740026|RGD:2324854
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pfn1	IDA		Rat	PMID:10966486|RGD:2324858
Biological Process	GO:0050434	positive regulation of viral transcription	Pfn1	IMP		Rat	PMID:12740026|RGD:2324854
Biological Process	GO:0050821	protein stabilization	PFN1	IDA		Human	PMID:18573880
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Pfn1	IGI	MGI:MGI:2446472	Mouse	PMID:15615774
Biological Process	GO:0010033	response to organic substance	Pfn1	IEP		Rat	PMID:8297366|RGD:2324861
Biological Process	GO:0060074	synapse maturation	Pfn1	IDA		Mouse	PMID:26951674
Biological Process	GO:0060074	synapse maturation	Pfn1	IMP		Mouse	PMID:26951674

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern