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Pfn1
Gene Detail
Symbol

Name
ID
Pfn1
profilin 1
MGI:97549
Synonyms
actin binding protein, Pfn
Feature Type
protein coding gene
Genetic Map
Chromosome 11
43.21 cM, cytoband A-D
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:70651850-70654644 bp, - strand
From VEGA annotation of GRCm38

  2795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3684  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: profilin
Gene Tree: Pfn1

Human
homologs
Human Homolog PFN1, profilin 1
NCBI Gene ID 5216
neXtProt AC  NX_P07737
Human Synonyms  ALS18
Human Chr (Location)  17p13.3; chr17:4945650-4949086 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PFN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(9) Targeted(7)
Incidental mutations (data from Mutagenetix )
 
Homozygous mice die at early embryonic stages. Some heterozygous mice die either in early embryonic stages or in the perinatal period; animals that survive reach adulthood and are phenotypically normal.
 
Interactions
Pfn1 interacts with 119 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (32)    Tissues (14)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
Western blot 20
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(11) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006068 (Evidence)
Ensembl Gene ModelENSMUSG00000018293 (Evidence)
Entrez Gene18643 (Evidence)
DoTSDT.101195573, DT.101208796, DT.101725796, DT.110532472, DT.537015, DT.91310643
NIA Mouse Gene IndexU033007
Consensus CDS ProjectCCDS24960.1
International Mouse Knockout Project StatusPfn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006068 VEGA Gene Model | MGI Sequence Detail 2795 C57BL/6J ±  kb
transcript OTTMUST00000013681 VEGA | MGI Sequence Detail 861 Not Applicable 
polypeptide OTTMUSP00000006342 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005455 Profilin
InterPro IPR005454 Profilin, chordates
InterPro IPR027310 Profilin conserved site
Protein Ontology PR:000012585 profilin-1
References
(Earliest) J:15669 Kwiatkowski DJ, et al., Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis. J Biol Chem. 1988 Apr 25;263(12):5910-5
(Latest) J:208691 Zheng J, et al., Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood. 2014 Feb 13;123(7):992-1001
All references(59)
Other
accession IDs
MGD-MRK-13248, MGD-MRK-13249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory