Pfn1
Gene Detail

Symbol Name ID

Pfn1 profilin 1 MGI:97549

Synonyms

actin binding protein, Pfn

Feature Type

protein coding gene

Genetic Map

Chromosome 11

43.21 cM, cytoband A-D
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:70651850-70654644 bp, - strand From VEGA annotation of GRCm38   2795 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Pfn1 ± 2 cM)

Protein SuperFamily: profilin
Gene Tree: Pfn1

Human ortholog

PFN1 profilin 1 NCBI Gene ID 5216
Human Synonyms: ALS18
Human Chr17:4848947-4851825 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PFN1 (1)

Alleles and phenotypes

All alleles(15) : Targeted(6) Gene trapped(9)
 

Homozygous mice die at early embryonic stages. Some heterozygous mice die either in early embryonic stages or in the perinatal period; animals that survive reach adulthood and are phenotypically normal.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	actin cytoskeleton organization, neural tube closure, ...
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, phosphatidylinositol-4,5-bisphosphate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (32)    Tissues (14)    Images (3)
Theiler Stages: 16, 21, 23, 25, 26, 28

Assay Type	Results
Northern blot	12
Western blot	20

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(2) cDNA(11) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006068 (Evidence)
Ensembl Gene Model	ENSMUSG00000018293 (Evidence)
Entrez Gene	18643 (Evidence)
DoTS	DT.101195573, DT.101208796, DT.101725796, DT.110532472, DT.537015, DT.91310643
NIA Mouse Gene Index	U033007
Consensus CDS Project	CCDS24960.1
International Mouse Knockout Project Status	Pfn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006068	VEGA Gene Model | MGI Sequence Detail	2795	C57BL/6J
transcript	OTTMUST00000013681	VEGA | MGI Sequence Detail	861	Not Applicable
polypeptide	OTTMUSP00000006342	VEGA | MGI Sequence Detail	140	Not Applicable

All sequences(44) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002097	Profilin/allergen
InterPro	IPR005454	Profilin, Mammalian
Protein Ontology	PR:000012585	profilin-1

References

(Earliest) J:15669 Kwiatkowski DJ, et al., Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis. J Biol Chem. 1988 Apr 25;263(12):5910-5
(Latest) J:193938 Fan Y, et al., Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol. 2012 Oct;14(10):1046-56
All references(53)

Other accession IDs

MGD-MRK-13248, MGD-MRK-13249