Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDIA6
  • Mouse genes Pdia6
  • Rat genes Pdia6
  • Zfish genes pdia6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdia6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060698	endoribonuclease inhibitor activity	Pdia6	IMP		Mouse	PMID:24508390
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:P05106	Human	PMID:15466936
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:Q13162	Human	PMID:21057456
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:O00182,UniProtKB:P07237,UniProtKB:P30101	Human	PMID:21670307
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:P11021	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:P11021	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:O43681	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDIA6	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pdia6	IPI	UniProtKB:Q9R0N3	Rat	PMID:24882364|RGD:8693368
Molecular Function	GO:0015035	protein-disulfide reductase activity	PDIA6	IDA		Human	PMID:16677074
Molecular Function	GO:0015035	protein-disulfide reductase activity	Pdia6	IMP		Mouse	PMID:24508390
Cellular Component	GO:0005829	cytosol	PDIA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	PDIA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0034663	endoplasmic reticulum chaperone complex	Pdia6	IDA		Mouse	MGI:MGI:5613481|PMID:12475965
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Pdia6	IDA		Rat	PMID:14561759|RGD:1580664
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	PDIA6	IDA		Human	PMID:15308636
Cellular Component	GO:0070062	extracellular exosome	PDIA6	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	PDIA6	IDA		Human	PMID:19995400
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Pdia6	IDA		Rat	PMID:22665516|RGD:8553430
Biological Process	GO:1903895	negative regulation of IRE1-mediated unfolded protein response	Pdia6	IMP		Mouse	PMID:24508390

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern