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Pdia6 Gene Detail
Summary
  • Symbol
    Pdia6
  • Name
    protein disulfide isomerase associated 6
  • Synonyms
    1700015E05Rik, CaBP5, P5, Txndc7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919103
    NCBI Gene: 71853
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:17316590-17334786 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919103
protein coding gene Chr12:17316546-17334786 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019617
protein coding gene Chr12:14692926-14711186 (+)
A/J MGP_AJ_G0019584
protein coding gene Chr12:14173401-14191603 (+)
AKR/J MGP_AKRJ_G0019554
protein coding gene Chr12:14842611-14860858 (+)
BALB/cJ MGP_BALBcJ_G0019560
protein coding gene Chr12:14418265-14436479 (+)
C3H/HeJ MGP_C3HHeJ_G0019365
protein coding gene Chr12:14742722-14760962 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020008
protein coding gene Chr12:15174344-15192539 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017634
protein coding gene Chr12:13667796-13686325 (+)
CAST/EiJ MGP_CASTEiJ_G0018920
protein coding gene Chr12:14640017-14659413 (+)
CBA/J MGP_CBAJ_G0019336
protein coding gene Chr12:16004334-16022584 (+)
DBA/2J MGP_DBA2J_G0019449
protein coding gene Chr12:14086741-14105001 (+)
FVB/NJ MGP_FVBNJ_G0019440
protein coding gene Chr12:13971321-13989580 (+)
LP/J MGP_LPJ_G0019520
protein coding gene Chr12:14809385-14827828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019475
protein coding gene Chr12:15872207-15890486 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020047
protein coding gene Chr12:14525332-14543592 (+)
PWK/PhJ MGP_PWKPhJ_G0018686
protein coding gene Chr12:14126362-14144900 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018476
protein coding gene Chr12:14721988-14740326 (+)
WSB/EiJ MGP_WSBEiJ_G0018971
protein coding gene Chr12:14653373-14671617 (+)



Homology
more
  • Human Ortholog
    PDIA6, protein disulfide isomerase family A member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDIA6, protein disulfide isomerase family A member 6
  • Synonyms
    ERP5, P5, TXNDC7
  • Links
    NCBI Gene ID: 10130
    neXtProt AC: NX_Q15084
    UniProt: Q15084

  • Chr Location
    2p25.1; chr2:10783391-10837977 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit preweaning lethality. Mice homozygous for a hypomorphic allele exhibit reduced body weight and impaired T cell-independent and dependent antibody responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71853 NCBI Gene Model | MGI Sequence Detail 18197 C57BL/6J ±  kb
    transcript NM_027959 RefSeq | MGI Sequence Detail 2146 C57BL/6  
    polypeptide Q922R8 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 500
      cDNA 499
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141538, MGI:2145086
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:54354 Ferrari DM, et al., The protein disulphide-isomerase family: unravelling a string of folds. Biochem J. 1999 Apr 1;339(Pt 1):1-10
    • Latest
      J:312492 Chhabra NF, et al., A point mutation in the Pdia6 gene results in loss of pancreatic beta-cell identity causing overt diabetes. Mol Metab. 2021 Sep 4;54:101334

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    01/12/2022
    MGI 6.17
    The Jackson Laboratory