Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pdgfra

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PDGFRA
- Mouse genes Pdgfra
- Rat genes Pdgfra
- Zfish genes pdgfra
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdgfra

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0062063	BBSome binding	Pdgfra	IDA		Mouse	PMID:23160237
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Pdgfra	IPI	RGD:3329	Rat	PMID:18421086\|RGD:4108491
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	PDGFRA	IDA		Human	PMID:10806482
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	PDGFRA	IDA		Human	PMID:2536956
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	PDGFRA	IMP		Human	PMID:2554309
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	PDGFRA	IDA		Human	PMID:8188664
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	Pdgfra	IDA		Mouse	MGI:MGI:5294530\|PMID:20110689
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	Pdgfra	IDA		Rat	PMID:2157969\|RGD:729439
Molecular Function	GO:0048407	platelet-derived growth factor binding	PDGFRA	IPI	UniProtKB:Q9NRA1	Human	PMID:10806482
Molecular Function	GO:0048407	platelet-derived growth factor binding	PDGFRA	IPI	UniProtKB:P01127	Human	PMID:2536956
Molecular Function	GO:0048407	platelet-derived growth factor binding	PDGFRA	IPI	UniProtKB:P04085	Human	PMID:2536956
Molecular Function	GO:0048407	platelet-derived growth factor binding	PDGFRA	IDA		Human	PMID:2554309
Molecular Function	GO:0048407	platelet-derived growth factor binding	PDGFRA	IDA		Human	PMID:8188664
Molecular Function	GO:0048407	platelet-derived growth factor binding	Pdgfra	IDA		Mouse	MGI:MGI:5294530\|PMID:20110689
Molecular Function	GO:0048407	platelet-derived growth factor binding	Pdgfra	IDA		Mouse	PMID:15372073
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	PDGFRA	IPI	UniProtKB:P09619	Human	PMID:2542288
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P46108	Human	PMID:10733900
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P01127	Human	PMID:10806482
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:Q9NRA1	Human	PMID:10806482
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P15692-4	Human	PMID:17470632
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P04085	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P46108	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P46109	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:Q8N6L0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:Q9NRA1	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P01127	Human	PMID:7679113
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P04085	Human	PMID:7679113
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P46108	Human	PMID:9546424
Molecular Function	GO:0005515	protein binding	PDGFRA	IPI	UniProtKB:P46109	Human	PMID:9546424
Molecular Function	GO:0042803	protein homodimerization activity	PDGFRA	IDA		Human	PMID:2542288
Molecular Function	GO:0004672	protein kinase activity	PDGFRA	IDA		Human	PMID:24190966
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PDGFRA	IDA		Human	PMID:1646396
Molecular Function	GO:0038085	vascular endothelial growth factor binding	PDGFRA	IPI	UniProtKB:P15692	Human	PMID:17470632
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	PDGFRA	IDA		Human	PMID:17470632
Cellular Component	GO:0030424	axon	Pdgfra	IDA		Rat	PMID:19909480\|RGD:11080976
Cellular Component	GO:0030054	cell junction	PDGFRA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	Pdgfra	IDA		Mouse	MGI:MGI:5448504\|PMID:22265737
Cellular Component	GO:0005929	cilium	Pdgfra	IDA		Mouse	MGI:MGI:6108066\|PMID:29237719
Cellular Component	GO:0005737	cytoplasm	Pdgfra	IDA		Mouse	PMID:22027834
Cellular Component	GO:0005737	cytoplasm	Pdgfra	IDA		Rat	PMID:11788434\|RGD:8554178
Cellular Component	GO:0009897	external side of plasma membrane	Pdgfra	IDA		Mouse	PMID:17350578
Cellular Component	GO:0005794	Golgi apparatus	Pdgfra	IDA		Mouse	MGI:MGI:6108066\|PMID:29237719
Cellular Component	GO:0016020	membrane	PDGFRA	HDA		Human	PMID:19946888
Cellular Component	GO:0005902	microvillus	Pdgfra	IDA		Mouse	PMID:23266329
Cellular Component	GO:0005654	nucleoplasm	PDGFRA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Pdgfra	IDA		Mouse	PMID:21146513
Cellular Component	GO:0005634	nucleus	Pdgfra	IDA		Rat	PMID:11788434\|RGD:8554178
Cellular Component	GO:0005886	plasma membrane	PDGFRA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PDGFRA	IDA		Human	PMID:2536956
Cellular Component	GO:0005886	plasma membrane	PDGFRA	IDA		Human	PMID:2554309
Cellular Component	GO:0005886	plasma membrane	Pdgfra	IDA		Rat	PMID:11788434\|RGD:8554178
Cellular Component	GO:0032991	protein-containing complex	PDGFRA	IDA		Human	PMID:24190966
Biological Process	GO:0030325	adrenal gland development	Pdgfra	IGI	MGI:MGI:97531	Mouse	PMID:19056881
Biological Process	GO:0007568	aging	Pdgfra	IEP		Rat	PMID:1657776\|RGD:11080972
Biological Process	GO:0009653	anatomical structure morphogenesis	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:15543606
Biological Process	GO:0009887	animal organ morphogenesis	Pdgfra	IMP		Mouse	PMID:10806482
Biological Process	GO:0007420	brain development	Pdgfra	IEP		Rat	PMID:8714519\|RGD:11084933
Biological Process	GO:0003261	cardiac muscle progenitor cell migration to the midline involved in heart field formation	pdgfra	IMP	ZFIN:ZDB-GENO-170510-2	Zfish	PMID:28098558
Biological Process	GO:0055003	cardiac myofibril assembly	Pdgfra	IGI	UniProtKB:P05622	Mouse	MGI:MGI:1931346\|PMID:11239463
Biological Process	GO:0003317	cardioblast cell midline fusion	pdgfra	IMP	ZFIN:ZDB-GENO-170925-2	Zfish	PMID:28167492
Biological Process	GO:0060326	cell chemotaxis	PDGFRA	IMP		Human	PMID:1646396
Biological Process	GO:0060326	cell chemotaxis	Pdgfra	IMP		Mouse	MGI:MGI:5294530\|PMID:20110689
Biological Process	GO:0016477	cell migration	Pdgfra	IMP		Mouse	MGI:MGI:5294530\|PMID:20110689
Biological Process	GO:0071230	cellular response to amino acid stimulus	Pdgfra	IDA		Mouse	PMID:20548288
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Pdgfra	IEP		Rat	PMID:14593115\|RGD:1581771
Biological Process	GO:0071347	cellular response to interleukin-1	Pdgfra	IEP		Rat	PMID:7546776\|RGD:10449507
Biological Process	GO:0034614	cellular response to reactive oxygen species	PDGFRA	IDA		Human	PMID:24190966
Biological Process	GO:0061300	cerebellum vasculature development	pdgfra	IGI	ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3,ZFIN:ZDB-MRPHLNO-140310-12	Zfish	PMID:25250569
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Pdgfra	IMP		Mouse	MGI:MGI:894516\|PMID:9226440
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	pdgfra	IMP	ZFIN:ZDB-GENO-130920-1	Zfish	PMID:23861062
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Pdgfra	IMP		Mouse	MGI:MGI:1860627\|PMID:10903171
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	pdgfra	IMP	ZFIN:ZDB-GENO-130920-1	Zfish	PMID:26971580
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	pdgfra	IGI	ZFIN:ZDB-GENO-160920-8	Zfish	PMID:26971580
Biological Process	GO:0008210	estrogen metabolic process	Pdgfra	IGI	MGI:MGI:1914283	Mouse	PMID:19056881
Biological Process	GO:0030198	extracellular matrix organization	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:15543606
Biological Process	GO:0060325	face morphogenesis	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:17143286
Biological Process	GO:0008585	female gonad development	Pdgfra	IGI	MGI:MGI:1914283	Mouse	PMID:19056881
Biological Process	GO:0007507	heart development	pdgfra	IMP	ZFIN:ZDB-GENO-170925-2	Zfish	PMID:28167492
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Pdgfra	IMP		Mouse	PMID:24029230
Biological Process	GO:0001701	in utero embryonic development	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:10331973
Biological Process	GO:0001701	in utero embryonic development	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:17143286
Biological Process	GO:0048839	inner ear development	Pdgfra	IEP		Rat	PMID:15267171\|RGD:2292167
Biological Process	GO:0033327	Leydig cell differentiation	Pdgfra	IMP	MGI:MGI:2449440,MGI:MGI:3689423	Mouse	PMID:19056881
Biological Process	GO:0030324	lung development	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:11803579
Biological Process	GO:0060437	lung growth	Pdgfra	IMP		Rat	PMID:8879189\|RGD:11087558
Biological Process	GO:0001553	luteinization	Pdgfra	IMP	MGI:MGI:2449440,MGI:MGI:3689423	Mouse	PMID:19056881
Biological Process	GO:0001553	luteinization	Pdgfra	IGI	MGI:MGI:1914283	Mouse	PMID:19056881
Biological Process	GO:0030539	male genitalia development	Pdgfra	IMP	MGI:MGI:1926714	Mouse	PMID:12651897
Biological Process	GO:0008584	male gonad development	Pdgfra	IEP		Rat	PMID:11870082\|RGD:11087559
Biological Process	GO:0072277	metanephric glomerular capillary formation	Pdgfra	IGI	UniProtKB:P05622	Mouse	MGI:MGI:1931346\|PMID:11239463
Biological Process	GO:0010544	negative regulation of platelet activation	PDGFRA	IDA		Human	PMID:8188664
Biological Process	GO:0001755	neural crest cell migration	pdgfra	IGI	ZFIN:ZDB-GENE-030805-2	Zfish	PMID:28394883
Biological Process	GO:0001755	neural crest cell migration	pdgfra	IMP	ZFIN:ZDB-MRPHLNO-140310-11	Zfish	PMID:28394883
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:15543606
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	PDGFRA	IDA		Human	PMID:1646396
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	PDGFRA	IDA		Human	PMID:2536956
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	PDGFRA	IDA		Human	PMID:8188664
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Pdgfra	IDA		Mouse	MGI:MGI:5294530\|PMID:20110689
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	PDGFRA	IMP		Human	PMID:2554309
Biological Process	GO:0070527	platelet aggregation	PDGFRA	IMP		Human	PMID:8188664
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	PDGFRA	IDA		Human	PMID:10806482
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	PDGFRA	IDA		Human	PMID:2536956
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:17143286
Biological Process	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	PDGFRA	IMP		Human	PMID:2554309
Biological Process	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	Pdgfra	IDA		Mouse	MGI:MGI:5294530\|PMID:20110689
Biological Process	GO:0061047	positive regulation of branching involved in lung morphogenesis	Pdgfra	IMP		Rat	PMID:8879189\|RGD:11087558
Biological Process	GO:0030335	positive regulation of cell migration	PDGFRA	IMP		Human	PMID:1646396
Biological Process	GO:0030335	positive regulation of cell migration	PDGFRA	IDA		Human	PMID:17470632
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFRA	IDA		Human	PMID:10806482
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFRA	IMP		Human	PMID:2554309
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pdgfra	IMP		Rat	PMID:15267171\|RGD:2292167
Biological Process	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	PDGFRA	IDA		Human	PMID:17470632
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	PDGFRA	IMP		Human	PMID:2554309
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PDGFRA	IMP		Human	PMID:10734113
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	PDGFRA	IDA		Human	PMID:10806482
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Pdgfra	IDA		Rat	PMID:2157969\|RGD:729439
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PDGFRA	IMP		Human	PMID:1646396
Biological Process	GO:0010863	positive regulation of phospholipase C activity	PDGFRA	IMP		Human	PMID:1646396
Biological Process	GO:0046777	protein autophosphorylation	PDGFRA	IDA		Human	PMID:1646396
Biological Process	GO:0046777	protein autophosphorylation	PDGFRA	IDA		Human	PMID:2536956
Biological Process	GO:0046777	protein autophosphorylation	PDGFRA	IDA		Human	PMID:8188664
Biological Process	GO:0046777	protein autophosphorylation	Pdgfra	IDA		Mouse	MGI:MGI:5294530\|PMID:20110689
Biological Process	GO:0050920	regulation of chemotaxis	PDGFRA	IMP		Human	PMID:2554309
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	pdgfra	IGI	ZFIN:ZDB-GENE-030805-2	Zfish	PMID:28394883
Biological Process	GO:2000739	regulation of mesenchymal stem cell differentiation	PDGFRA	IMP		Human	PMID:21596750
Biological Process	GO:0034097	response to cytokine	Pdgfra	IEP		Rat	PMID:15155567\|RGD:2292169
Biological Process	GO:0032355	response to estradiol	Pdgfra	IEP		Rat	PMID:14724432\|RGD:2292171
Biological Process	GO:0043627	response to estrogen	Pdgfra	IEP		Rat	PMID:14724432\|RGD:2292171
Biological Process	GO:1904404	response to formaldehyde	Pdgfra	IEP		Rat	PMID:18045764\|RGD:2317372
Biological Process	GO:0009725	response to hormone	Pdgfra	IEP		Rat	PMID:15534218\|RGD:2292164
Biological Process	GO:0055093	response to hyperoxia	Pdgfra	IEP		Rat	PMID:15722379\|RGD:1580851
Biological Process	GO:0010035	response to inorganic substance	Pdgfra	IEP		Rat	PMID:17134509\|RGD:2292160
Biological Process	GO:0010033	response to organic substance	Pdgfra	IEP		Rat	PMID:17134509\|RGD:2292160
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Pdgfra	IGI	UniProtKB:P05622	Mouse	MGI:MGI:1931346\|PMID:11239463
Biological Process	GO:0060021	roof of mouth development	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:17143286
Biological Process	GO:0060021	roof of mouth development	pdgfra	IMP	ZFIN:ZDB-GENO-081008-1	Zfish	PMID:18264099
Biological Process	GO:0060021	roof of mouth development	pdgfra	IMP	ZFIN:ZDB-GENO-130920-1	Zfish	PMID:23861062
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Pdgfra	IDA		Mouse	PMID:18462699
Biological Process	GO:0048705	skeletal system morphogenesis	Pdgfra	IMP	MGI:MGI:1926728	Mouse	PMID:17143286
Biological Process	GO:0050872	white fat cell differentiation	Pdgfra	IMP	MGI:MGI:2656539,MGI:MGI:3838510	Mouse	PMID:28049691
Biological Process	GO:0050872	white fat cell differentiation	Pdgfra	IMP	MGI:MGI:2135565,MGI:MGI:3838504	Mouse	PMID:28049691
Biological Process	GO:0042060	wound healing	Pdgfra	IMP		Mouse	MGI:MGI:5294530\|PMID:20110689
Biological Process	GO:0042060	wound healing	Pdgfra	IEP		Rat	PMID:16383039\|RGD:2292163

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.