About   Help   FAQ
Pdgfra
Gene Detail
Symbol

Name
ID
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
MGI:97530
Synonyms
CD140a, Pdgfr-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
39.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr5:75152291-75198204 bp, + strand
From NCBI annotation of GRCm38

  45914 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Pdgfra

Human
homologs
Human Homolog PDGFRA, platelet-derived growth factor receptor, alpha polypeptide
NCBI Gene ID 5156
neXtProt AC  NX_P16234
Human Synonyms  CD140A, PDGFR2, PDGFR-2, RHEPDGFRA
Human Chr (Location)  4q12; chr4:54229097-54298245 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PDGFRA
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(1) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit incomplete cephalic closure, increased apoptosis of neural crest cells, impaired myotome and testis formation, abnormal mucosal linings, thoracic skeletal defects, and midgestational lethality.
 
Human Diseases Modeled Using Mouse Pdgfra (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Pdgfra interacts with 426 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (93 annotations)
Process adrenal gland development, anatomical structure morphogenesis, ...
Component cell surface, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (268 records)
Data Summary: Results (739)    Tissues (482)    Images (207)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 26
RNA in situ 563
In situ reporter (knock in) 72
Northern blot 8
Western blot 8
RT-PCR 46
RNase protection 16
cDNA source data(45)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) Genomic(9) cDNA(59) Primer pair(5) Other(18)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000029231 (Evidence)
Entrez Gene18595 (Evidence)
DFCITC1577498, TC1586618, TC1594036, TC1624852, TC1633686, TC1695594, TC1713840
DoTSDT.101174656, DT.101386045, DT.101386048, DT.101738466, DT.110651179, DT.40155758, DT.534547
NIA Mouse Gene IndexU040640
EC2.7.10.1
Consensus CDS ProjectCCDS19351.1
International Mouse Knockout Project StatusPdgfra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18595 NCBI Gene Model | MGI Sequence Detail 45914 C57BL/6J ±  kb
transcript NM_001083316 RefSeq | MGI Sequence Detail 6570 C57BL/6 
polypeptide P26618 UniProt | EBI | MGI Sequence Detail 1089 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(10) : SNPs within 2kb(243 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR027290 Platelet-derived growth factor receptor alpha
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology PR:000002030 alpha-type platelet-derived growth factor receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:99 Gruneberg H, et al., Two closely linked genes in the mouse. Genet Res. 1960;1:69-90
(Latest) J:211984 Wright JH, et al., Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma. Int J Cancer. 2014 Feb 15;134(4):778-88
All references(408)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13215, MGD-MRK-13216, MGI:2140805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory