About   Help   FAQ
Pdgfra Gene Detail
Summary
  • Symbol
    Pdgfra
  • Name
    platelet derived growth factor receptor, alpha polypeptide
  • Synonyms
    CD140a, Pdgfr-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97530
    NCBI Gene: 18595
  • Alliance
  • Transcription Start Sites
    15 TSS
  • Candidate for QTL
    5 QTL
Location &
Maps
more
  • Sequence Map
    Chr5:75312953-75358876 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 39.55 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97530
protein coding gene Chr5:75311988-75358876 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029637
protein coding gene Chr5:75272496-75321528 (+)
A/J MGP_AJ_G0029605
protein coding gene Chr5:72417985-72463684 (+)
AKR/J MGP_AKRJ_G0029553
protein coding gene Chr5:74773377-74819490 (+)
BALB/cJ MGP_BALBcJ_G0029614
protein coding gene Chr5:73119517-73167632 (+)
C3H/HeJ MGP_C3HHeJ_G0029337
protein coding gene Chr5:75158918-75205393 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030068
protein coding gene Chr5:78303537-78349133 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027309
protein coding gene Chr5:68087175-68132222 (+)
CAST/EiJ MGP_CASTEiJ_G0028745
protein coding gene Chr5:74273468-74324456 (+)
CBA/J MGP_CBAJ_G0029306
protein coding gene Chr5:80899053-80944561 (+)
DBA/2J MGP_DBA2J_G0029451
protein coding gene Chr5:72487557-72534558 (+)
FVB/NJ MGP_FVBNJ_G0029412
protein coding gene Chr5:71641990-71691916 (+)
LP/J MGP_LPJ_G0029538
protein coding gene Chr5:75704640-75754183 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029440
protein coding gene Chr5:84104679-84153109 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030101
protein coding gene Chr5:74306542-74359382 (+)
PWK/PhJ MGP_PWKPhJ_G0028468
protein coding gene Chr5:71481898-71531947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028303
protein coding gene Chr5:73654603-73717107 (+)
WSB/EiJ MGP_WSBEiJ_G0028825
protein coding gene Chr5:74596075-74649079 (+)



Homology
more
  • Human Ortholog
    PDGFRA, platelet derived growth factor receptor alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDGFRA, platelet derived growth factor receptor alpha
  • Synonyms
    CD140A, PDGFR2, PDGFR-2
  • Links
    NCBI Gene ID: 5156
    neXtProt AC: NX_P16234
    UniProt: P16234

  • Chr Location
    4q12; chr4:54229280-54298245 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Pdgfra mouse models; 6 with human PDGFRA associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    139 phenotypes from 15 alleles in 13 genetic backgrounds
    79 phenotypes from multigenic genotypes
    677 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit incomplete cephalic closure, increased apoptosis of neural crest cells, impaired myotome and testis formation, abnormal mucosal linings, thoracic skeletal defects, and midgestational lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029231 Ensembl Gene Model | MGI Sequence Detail 45924 C57BL/6J ±  kb
    transcript ENSMUST00000000476 Ensembl | MGI Sequence Detail 6549 Not Applicable  
    polypeptide ENSMUSP00000000476 Ensembl | MGI Sequence Detail 1089 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      Genomic 9
      cDNA 64
      Primer pair 22
      Other 27

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13215, MGD-MRK-13216, MGI:2140805
    References
    more
    • Summaries
      All 1236
      Developmental Gene Expression 524
      Diseases 3
      Gene Ontology 30
      Phenotypes 677
    • Earliest
      J:99 Gruneberg H, et al., Two closely linked genes in the mouse. Genet Res. 1960;1(1):69-90
    • Latest
      J:344961 Simpson JE, et al., Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling. Dev Cell. 2024 Jan 22;59(2):228-243.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory