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Pdgfra
Gene Detail
Symbol

Name
ID
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
MGI:97530
Synonyms
CD140a, Pdgfr-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
39.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr5:75152291-75198204 bp, + strand
From Ensembl annotation of GRCm38

  45914 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDGFRA
Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Pdgfra

Human
homologs
PDGFRA, platelet-derived growth factor receptor, alpha polypeptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5156
neXtProt AC: NX_P16234

Human Synonyms: CD140A, PDGFR2, PDGFR-2, RHEPDGFRA

Human Chr (Location): 4q12; chr4:54229097-54298245 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PDGFRA

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(1) Radiation induced(1) Targeted(18)
Genomic Mutations involving Pdgfra (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit incomplete cephalic closure, increased apoptosis of neural crest cells, impaired myotome and testis formation, abnormal mucosal linings, thoracic skeletal defects, and midgestational lethality.
 
Human Diseases Modeled in Mice Using Pdgfra (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Pdgfra interacts with 426 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (94 annotations)
Process adrenal gland development, anatomical structure morphogenesis, ...
Component cell surface, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (291 records)
Data Summary: Results (839)    Tissues (536)    Images (229)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 112
RNA in situ 566
In situ reporter (knock in) 83
Northern blot 8
Western blot 8
RT-PCR 46
RNase protection 16
cDNA source data(45)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PDGFRA ; Xenbase pdgfra ; ZFIN pdgfra    NEW 
Molecular
reagents
All nucleic(92) Genomic(9) cDNA(60) Primer pair(5) Other(18)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000029231 (Evidence)
Entrez Gene 18595 (Evidence)
DFCI TC1577498, TC1586618, TC1594036, TC1624852, TC1633686, TC1695594, TC1713840
DoTS DT.101174656, DT.101386045, DT.101386048, DT.101738466, DT.110651179, DT.40155758, DT.534547
NIA Mouse Gene Index U040640
EC 2.7.10.1
Consensus CDS Project CCDS19351.1
International Mouse Phenotyping Consortium Status Pdgfra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029231 Ensembl Gene Model | MGI Sequence Detail 45914 C57BL/6J ±  kb
transcript ENSMUST00000000476 Ensembl | MGI Sequence Detail 6553 Not Applicable 
polypeptide ENSMUSP00000000476 Ensembl | MGI Sequence Detail 1089 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(10) : SNPs within 2kb(243 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR027290 Platelet-derived growth factor receptor alpha
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor family
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology PR:000002030 alpha-type platelet-derived growth factor receptor
References
(Earliest) J:99 Gruneberg H, et al., Two closely linked genes in the mouse. Genet Res. 1960;1:69-90
(Latest) J:222958 Vasudevan HN, et al., Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. Elife. 2015;4
All references(442)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13215, MGD-MRK-13216, MGI:2140805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory