Pdgfra
Gene Detail

Symbol Name ID

Pdgfra platelet derived growth factor receptor, alpha polypeptide MGI:97530

Synonyms

CD140a, Pdgfr-2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

39.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)

Sequence Map

Chr5:75152291-75198204 bp, + strand From NCBI annotation of GRCm38   45914 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Pdgfra

Human homologs

Human Homolog		PDGFRA, platelet-derived growth factor receptor, alpha polypeptide
NCBI Gene ID		5156
neXtProt AC		NX_P16234
Human Synonyms		CD140A, PDGFR2, PDGFR-2, RHEPDGFRA
Human Chr (Location)		4q12; chr4:55095264-55164412 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PDGFRA

Alleles and phenotypes

All alleles(16) : Targeted(15) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit incomplete cephalic closure, increased apoptosis of neural crest cells, impaired myotome and testis formation, abnormal mucosal linings, thoracic skeletal defects, and midgestational lethality.

 
Human Diseases Modeled Using Mouse Pdgfra (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (94 annotations)

Process	adrenal gland development, anatomical structure morphogenesis, ...
Component	cell surface, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (242 records)
Data Summary: Results (584)    Tissues (394)    Images (139)
Theiler Stages: 2, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	11
RNA in situ	495
Northern blot	8
Western blot	8
RT-PCR	46
RNase protection	16

cDNA source data(45)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(87) Genomic(9) cDNA(58) Primer pair(4) Other(16)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000029231 (Evidence)
Entrez Gene	18595 (Evidence)
DFCI	TC1577498, TC1586618, TC1594036, TC1624852, TC1633686, TC1695594, TC1713840
DoTS	DT.101174656, DT.101386045, DT.101386048, DT.101738466, DT.110651179, DT.40155758, DT.534547
NIA Mouse Gene Index	U040640
EC	2.7.10.1
Consensus CDS Project	CCDS19351.1
International Mouse Knockout Project Status	Pdgfra

Sequences

Length	Strain/Species
genomic	18595	NCBI Gene Model | MGI Sequence Detail	45914	C57BL/6J
transcript	NM_001083316	RefSeq | MGI Sequence Detail	6570	C57BL/6
polypeptide	P26618	UniProt | EBI | MGI Sequence Detail	1089	Not Applicable

All sequences(53) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(10) : SNPs(205 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR027290	Platelet-derived growth factor receptor alpha
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016243	Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
InterPro	IPR009134	Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
Protein Ontology	PR:000002030	alpha-type platelet-derived growth factor receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:99 Gruneberg H, et al., Two closely linked genes in the mouse. Genet Res. 1960;1:69-90
(Latest) J:196388 Kurahashi M, et al., A novel population of subepithelial platelet-derived growth factor receptor alpha-positive cells in the mouse and human colon. Am J Physiol Gastrointest Liver Physiol. 2013 May;304(9):G823-34
All references(368)

Other accession IDs

MGD-MRK-13215, MGD-MRK-13216, MGI:2140805