Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE5A
  • Mouse genes Pde5a
  • Rat genes Pde5a
  • Zfish genes pde5ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde5a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	PDE5A	IDA		Human	PMID:14687666
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Pde5a	IDA		Rat	PMID:15100365|RGD:1582531
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Pde5a	IDA		Rat	PMID:15623434|RGD:1582533
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Pde5a	IMP		Mouse	PMID:19474061
Molecular Function	GO:0030553	cGMP binding	Pde5a	IDA		Mouse	PMID:18534985
Molecular Function	GO:0030553	cGMP binding	Pde5a	IDA		Mouse	PMID:12554648
Molecular Function	GO:0004112	cyclic-nucleotide phosphodiesterase activity	Pde5a	IDA		Mouse	PMID:12554648
Molecular Function	GO:0005515	protein binding	PDE5A	IPI	UniProtKB:Q13976	Human	PMID:18757735
Molecular Function	GO:0005515	protein binding	PDE5A	IPI	UniProtKB:Q9NZD8	Human	PMID:32296183
Cellular Component	GO:0005829	cytosol	Pde5a	IDA		Rat	PMID:17141339|RGD:2314470
Biological Process	GO:0046069	cGMP catabolic process	Pde5a	IDA		Mouse	PMID:12554648
Biological Process	GO:0046068	cGMP metabolic process	Pde5a	IMP		Mouse	PMID:19474061
Biological Process	GO:0046068	cGMP metabolic process	Pde5a	IMP		Mouse	PMID:20511540
Biological Process	GO:0055118	negative regulation of cardiac muscle contraction	Pde5a	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0042130	negative regulation of T cell proliferation	Pde5a	IMP		Mouse	PMID:17101732
Biological Process	GO:0007399	nervous system development	Pde5a	IEP		Rat	PMID:9370351|RGD:729513
Biological Process	GO:0048599	oocyte development	Pde5a	IMP		Mouse	PMID:19474061
Biological Process	GO:0048599	oocyte development	Pde5a	IGI	MGI:MGI:1860764	Mouse	PMID:19474061
Biological Process	GO:0043065	positive regulation of apoptotic process	Pde5a	IMP		Rat	PMID:19474186|RGD:2314462
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	Pde5a	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0002678	positive regulation of chronic inflammatory response	Pde5a	IMP		Rat	PMID:19129291|RGD:2314463
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Pde5a	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0060282	positive regulation of oocyte development	Pde5a	IGI	MGI:MGI:1860764	Mouse	PMID:19474061
Biological Process	GO:0060282	positive regulation of oocyte development	Pde5a	IMP		Mouse	PMID:19474061
Biological Process	GO:0045907	positive regulation of vasoconstriction	Pde5a	IMP		Rat	PMID:19542492|RGD:2314461
Biological Process	GO:0010749	regulation of nitric oxide mediated signal transduction	Pde5a	IGI	MGI:MGI:2446107	Mouse	PMID:16150726
Biological Process	GO:0002026	regulation of the force of heart contraction	Pde5a	IMP		Rat	PMID:17606845|RGD:2314467
Biological Process	GO:0055119	relaxation of cardiac muscle	Pde5a	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0001666	response to hypoxia	Pde5a	IEP		Rat	PMID:12466227|RGD:1582528
Biological Process	GO:0032496	response to lipopolysaccharide	Pde5a	IEP		Rat	PMID:17141339|RGD:2314470
Biological Process	GO:0033574	response to testosterone	Pde5a	IEP		Rat	PMID:17138653|RGD:2314518
Biological Process	GO:0007614	short-term memory	Pde5a	IMP		Rat	PMID:19129291|RGD:2314463
Biological Process	GO:0042098	T cell proliferation	Pde5a	IMP		Mouse	PMID:17101732
Biological Process	GO:0042311	vasodilation	Pde5a	IEP		Rat	PMID:16545481|RGD:1582534

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern