Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PCSK6
  • Mouse genes Pcsk6
  • Rat genes Pcsk6
  • Zfish genes pcsk6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pcsk6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	PCSK6	IDA		Human	PMID:9242664
Molecular Function	GO:0008201	heparin binding	PCSK6	IDA		Human	PMID:12535616
Molecular Function	GO:0048406	nerve growth factor binding	PCSK6	IDA		Human	PMID:8615794
Molecular Function	GO:0005515	protein binding	PCSK6	IPI	UniProtKB:Q96D15	Human	PMID:16433634
Molecular Function	GO:0005515	protein binding	PCSK6	IPI	UniProtKB:Q8N8Z8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PCSK6	IPI	UniProtKB:Q92824-2	Human	PMID:32296183
Molecular Function	GO:0004252	serine-type endopeptidase activity	PCSK6	IDA		Human	PMID:8218226
Molecular Function	GO:0004252	serine-type endopeptidase activity	PCSK6	IDA		Human	PMID:8615794
Molecular Function	GO:0004252	serine-type endopeptidase activity	PCSK6	IDA		Human	PMID:8906861
Cellular Component	GO:0009986	cell surface	PCSK6	IDA		Human	PMID:12535616
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PCSK6	IDA		Human	PMID:12535616
Cellular Component	GO:0005615	extracellular space	PCSK6	IDA		Human	PMID:8906861
Biological Process	GO:0007368	determination of left/right symmetry	Pcsk6	IGI	MGI:MGI:97359	Mouse	PMID:10809672
Biological Process	GO:0009100	glycoprotein metabolic process	PCSK6	IDA		Human	PMID:8218226
Biological Process	GO:0032902	nerve growth factor production	PCSK6	IDA		Human	PMID:8615794
Biological Process	GO:0016486	peptide hormone processing	PCSK6	IDA		Human	PMID:9242664
Biological Process	GO:0016486	peptide hormone processing	Pcsk6	IEP		Rat	PMID:8070361|RGD:729476
Biological Process	GO:0016485	protein processing	PCSK6	IDA		Human	PMID:8218226
Biological Process	GO:0016485	protein processing	PCSK6	IDA		Human	PMID:9242664
Biological Process	GO:0016485	protein processing	PCSK6	IDA		Human	PMID:9738469
Biological Process	GO:0016485	protein processing	Pcsk6	IMP		Mouse	PMID:23918928
Biological Process	GO:0032940	secretion by cell	PCSK6	IDA		Human	PMID:8615794
Biological Process	GO:0007354	zygotic determination of anterior/posterior axis, embryo	Pcsk6	IMP	MGI:MGI:2181754	Mouse	PMID:10809672
Biological Process	GO:0007354	zygotic determination of anterior/posterior axis, embryo	Pcsk6	IGI	MGI:MGI:97359	Mouse	PMID:10809672

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern