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Pcsk6
Gene Detail
Symbol

Name
ID
Pcsk6
proprotein convertase subtilisin/kexin type 6
MGI:102897
Synonyms
PACE4, SPC4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
35.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:65861734-66050340 bp, + strand
From VEGA annotation of GRCm38

  188607 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20569  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PCSK6
Protein SuperFamily: proprotein convertase, subtilisin/kexin type
Gene Tree: Pcsk6

Human
homologs
PCSK6, proprotein convertase subtilisin/kexin type 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5046
neXtProt AC: NX_P29122

Human Synonyms: PACE4, SPC4

Human Chr (Location): 15q26.3; chr15:101303928-101489984 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(59) : Gene trapped(57) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in partial lethality by E15.5. Embryos develop situs ambiguus with left pulmonary isomerism or craniofacial malformations including cyclopia, or both.
 
Interactions
Pcsk6 interacts with 203 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process determination of left/right symmetry, glycoprotein metabolic process, ...
Component cell surface, extracellular matrix, ...
Function endopeptidase activity, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (252)    Tissues (71)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 244
RT-PCR 8
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PCSK6 ; Xenbase pcsk6    NEW 
Molecular
reagents
All nucleic(62) Genomic(1) cDNA(58) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000042239 (Evidence)
Ensembl Gene Model ENSMUSG00000030513 (Evidence)
Entrez Gene 18553 (Evidence)
UniGene 294007
DFCI TC1603517, TC1601297, TC1598112
DoTS DT.489888, DT.101399918, DT.101178696
NIA Mouse Gene Index U042815
Consensus CDS Project CCDS52267.1, CCDS71978.1
International Mouse Phenotyping Consortium Status Pcsk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042239 VEGA Gene Model | MGI Sequence Detail 188607 C57BL/6J ±  kb
transcript OTTMUST00000111029 VEGA | MGI Sequence Detail 4354 Not Applicable 
polypeptide OTTMUSP00000062052 VEGA | MGI Sequence Detail 959 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(2523 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR006212 Furin-like repeat
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000209 Peptidase S8/S53 domain
InterPro IPR023827 Peptidase S8, subtilisin, Asp-active site
InterPro IPR022398 Peptidase S8, subtilisin, His-active site
InterPro IPR015500 Peptidase S8, subtilisin-related
InterPro IPR023828 Peptidase S8, subtilisin, Ser-active site
InterPro IPR010909 PLAC
InterPro IPR002884 Proprotein convertase, P
InterPro IPR009020 Proteinase inhibitor, propeptide
Protein Ontology PR:000012438 proprotein convertase subtilisin/kexin type 6
References
(Earliest) J:52522 Steiner DF, et al., The new enzymology of precursor processing endoproteases. J Biol Chem. 1992 Nov 25;267(33):23435-8
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(71)
Other
accession IDs
MGD-MRK-23731, MGI:2142365

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory