Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PARL
  • Mouse genes Parl
  • Rat genes Parl
  • Zfish genes parla
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Parl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	PARL	IGI	UniProtKB:Q5XJY4	Human	PMID:21138942
Molecular Function	GO:0004175	endopeptidase activity	PARL	IMP		Human	PMID:21426348
Molecular Function	GO:0004175	endopeptidase activity	PARL	IDA		Human	PMID:22354088
Molecular Function	GO:0004175	endopeptidase activity	Parl	IMP		Mouse	MGI:MGI:5582161|PMID:21138942
Molecular Function	GO:0005515	protein binding	PARL	IPI	UniProtKB:Q9BXM7	Human	PMID:21138942
Molecular Function	GO:0005515	protein binding	Parl	IPI	UniProtKB:O35387	Mouse	MGI:MGI:3776580|PMID:18288109
Cellular Component	GO:0005743	mitochondrial inner membrane	Parl	IMP		Mouse	MGI:MGI:3692706|PMID:16839884
Cellular Component	GO:0005739	mitochondrion	PARL	IDA		Human	PMID:22354088
Cellular Component	GO:0005739	mitochondrion	Parl	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Parl	IDA		Rat	PMID:14732705|RGD:12880444
Cellular Component	GO:0005634	nucleus	Parl	IDA		Rat	PMID:14732705|RGD:12880444
Biological Process	GO:0033619	membrane protein proteolysis	PARL	IDA		Human	PMID:22354088
Biological Process	GO:0008053	mitochondrial fusion	Parl	IMP		Mouse	MGI:MGI:6450250|PMID:16713954
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	Parl	IMP		Mouse	MGI:MGI:3692706|PMID:16839884
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	Parl	IMP		Mouse	MGI:MGI:3692706|PMID:16839884
Biological Process	GO:0030182	neuron differentiation	Parl	IEP		Rat	PMID:14732705|RGD:12880444
Biological Process	GO:0006508	proteolysis	PARL	IGI	UniProtKB:Q5XJY4	Human	PMID:21138942
Biological Process	GO:0006508	proteolysis	PARL	IMP		Human	PMID:21426348
Biological Process	GO:0006508	proteolysis	Parl	IGI	UniProtKB:Q9H300	Mouse	MGI:MGI:5582158|PMID:21426348
Biological Process	GO:0006508	proteolysis	Parl	IMP		Mouse	MGI:MGI:5582161|PMID:21138942
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	Parl	IMP		Mouse	MGI:MGI:5619462|PMID:21355049
Biological Process	GO:0010821	regulation of mitochondrion organization	PARL	IMP		Human	PMID:21355049
Biological Process	GO:1903214	regulation of protein targeting to mitochondrion	PARL	IGI	UniProtKB:O60260|UniProtKB:Q9BXM7	Human	PMID:21355049
Biological Process	GO:0030162	regulation of proteolysis	PARL	IGI	UniProtKB:Q9BXM7	Human	PMID:21355049
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	PARL	IMP		Human	PMID:21138942
Biological Process	GO:0031667	response to nutrient levels	Parl	IEP		Rat	PMID:25336449|RGD:12880438

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern