Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PAK3
  • Mouse genes Pak3
  • Rat genes Pak3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pak3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051020	GTPase binding	Pak3	IDA		Rat	PMID:7559638|RGD:729464
Molecular Function	GO:0004708	MAP kinase kinase activity	PAK3	IDA		Human	PMID:21177870
Molecular Function	GO:0005515	protein binding	PAK3	IPI	UniProtKB:P60953-2	Human	PMID:11157984
Molecular Function	GO:0005515	protein binding	Pak3	IPI	UniProtKB:P60953	Mouse	MGI:MGI:77540|PMID:7493928
Molecular Function	GO:0005515	protein binding	Pak3	IPI	UniProtKB:P60953	Mouse	MGI:MGI:5512934|PMID:23022564
Molecular Function	GO:0004672	protein kinase activity	Pak3	IDA		Mouse	PMID:23509247
Molecular Function	GO:0004672	protein kinase activity	Pak3	IDA		Rat	PMID:7559638|RGD:729464
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK3	EXP		Human	PMID:17060906
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pak3	IDA		Rat	PMID:12237306|RGD:730063
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pak3	IDA		Rat	PMID:9823899|RGD:7775047
Molecular Function	GO:0031267	small GTPase binding	Pak3	IPI	UniProtKB:P17081	Mouse	MGI:MGI:3843447|PMID:10445846
Cellular Component	GO:0005768	endosome	Pak3	IDA		Rat	PMID:12890786|RGD:7775030
Cellular Component	GO:0098978	glutamatergic synapse	Pak3	IMP		Mouse	PMID:25851601
Cellular Component	GO:0098978	glutamatergic synapse	Pak3	IDA		Mouse	PMID:25851601
Cellular Component	GO:0098978	glutamatergic synapse	Pak3	IDA		Mouse	PMID:15182717
Cellular Component	GO:0098978	glutamatergic synapse	Pak3	IEP		Mouse	PMID:15182717
Cellular Component	GO:0014069	postsynaptic density	Pak3	IDA		Mouse	PMID:15182717
Cellular Component	GO:0014069	postsynaptic density	Pak3	IEP		Mouse	PMID:15182717
Biological Process	GO:0007409	axonogenesis	Pak3	IMP		Mouse	MGI:MGI:4940954|PMID:21115725
Biological Process	GO:0071407	cellular response to organic cyclic compound	Pak3	IDA		Mouse	PMID:23509247
Biological Process	GO:0016358	dendrite development	Pak3	IMP		Mouse	MGI:MGI:4940954|PMID:21115725
Biological Process	GO:0060996	dendritic spine development	Pak3	IGI	MGI:MGI:95564	Mouse	PMID:23509247
Biological Process	GO:0060997	dendritic spine morphogenesis	Pak3	IMP		Mouse	MGI:MGI:5825418|PMID:25851601
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Pak3	IMP		Rat	PMID:18481281|RGD:7775053
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	Pak3	IMP		Rat	PMID:12890786|RGD:7775030
Biological Process	GO:0010763	positive regulation of fibroblast migration	Pak3	IMP		Rat	PMID:23818969|RGD:10412710
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Pak3	IMP		Rat	PMID:12890786|RGD:7775030
Biological Process	GO:0006468	protein phosphorylation	Pak3	IDA		Rat	PMID:12237306|RGD:730063
Biological Process	GO:0006468	protein phosphorylation	Pak3	IDA		Rat	PMID:9823899|RGD:7775047
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Pak3	IMP		Rat	PMID:23818969|RGD:10412710
Biological Process	GO:0030833	regulation of actin filament polymerization	PAK3	IDA		Human	PMID:21177870
Biological Process	GO:0010975	regulation of neuron projection development	Pak3	IMP		Rat	PMID:15574732|RGD:7775029
Biological Process	GO:0099175	regulation of postsynapse organization	Pak3	IDA		Mouse	PMID:25851601
Biological Process	GO:0099175	regulation of postsynapse organization	Pak3	IMP		Mouse	PMID:25851601

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern