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Pak3
Gene Detail
 Symbol
Name
ID
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
MGI:1339656
Synonyms PAK-3
Feature Type protein coding gene
Genetic Map
Chromosome X
64.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:143518591-143797792 bp, + strand
From VEGA annotation of GRCm38

  279202 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Pak3

Human
homologs
Human Homolog PAK3, p21 protein (Cdc42/Rac)-activated kinase 3
NCBI Gene ID 5063
neXtProt AC  NX_O75914
Human Synonyms  bPAK, CDKN1A, hPAK3, MRX30, MRX47, OPHN3, PAK3beta
Human Chr (Location)  Xq23; chrX:110944285-111227362 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PAK3
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele display a selective impairment in hippocampal late-phase long-term potentiation, and deficits in learning and memory.
 
Interactions
Pak3 interacts with 503 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin cytoskeleton organization, activation of MAPK activity, ...
Component cytoplasm, endosome
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (105)    Tissues (82)    Images (10)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 24
RNA in situ 55
Northern blot 18
Western blot 8
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018957 (Evidence)
Ensembl Gene ModelENSMUSG00000031284 (Evidence)
Entrez Gene18481 (Evidence)
DFCITC1584463, TC1584764, TC1618789
DoTSDT.60118025, DT.91327589, DT.94189195
NIA Mouse Gene IndexU043797
EC2.7.11.1
PDB1EES
Consensus CDS ProjectCCDS30454.1, CCDS57779.1
International Mouse Knockout Project StatusPak3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018957 VEGA Gene Model | MGI Sequence Detail 279202 C57BL/6J ±  kb
transcript OTTMUST00000045533 VEGA | MGI Sequence Detail 8657 Not Applicable 
polypeptide OTTMUSP00000020470 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(26) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(969 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012242 serine/threonine-protein kinase PAK 3
References (Earliest) J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
(Latest) J:209016 Piccand J, et al., Pak3 promotes cell cycle exit and differentiation of beta-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes. 2014 Jan;63(1):203-15
All references(57)
Other
accession IDs
MGD-MRK-33717, MGI:106033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory