Pak3
Gene Detail

Symbol Name ID

Pak3 p21 protein (Cdc42/Rac)-activated kinase 3 MGI:1339656

Synonyms

PAK-3

Feature Type

protein coding gene

Genetic Map

Chromosome X

64.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:143518591-143797792 bp, + strand From VEGA annotation of GRCm38   279202 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Pak3

Human homologs

Human Homolog		PAK3, p21 protein (Cdc42/Rac)-activated kinase 3
NCBI Gene ID		5063
neXtProt AC		NX_O75914
Human Synonyms		bPAK, CDKN1A, hPAK3, MRX30, MRX47, OPHN3, PAK3beta
Human Chr (Location)		Xq23; chrX:110187513-110464173 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PAK3

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for one knock-out allele display a selective impairment in hippocampal late-phase long-term potentiation, and deficits in learning and memory.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	activation of MAPK activity, axonogenesis, ...
Component	cytoplasm, intracellular
Function	ATP binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (105)    Tissues (82)    Images (10)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	24
RNA in situ	55
Northern blot	18
Western blot	8

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(1) cDNA(11)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018957 (Evidence)
Ensembl Gene Model	ENSMUSG00000031284 (Evidence)
Entrez Gene	18481 (Evidence)
DFCI	TC1584463, TC1584764, TC1618789
DoTS	DT.60118025, DT.91327589, DT.94189195
NIA Mouse Gene Index	U043797
EC	2.7.11.1
PDB	1EES
Consensus CDS Project	CCDS30454.1, CCDS57779.1
International Mouse Knockout Project Status	Pak3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018957	VEGA Gene Model | MGI Sequence Detail	279202	C57BL/6J
transcript	OTTMUST00000045575	VEGA | MGI Sequence Detail	8348	Not Applicable
polypeptide	OTTMUSP00000020496	VEGA | MGI Sequence Detail	559	Not Applicable

All sequences(75) RefSeq(10) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(301 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000095	PAK-box/P21-Rho-binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000012242	serine/threonine-protein kinase PAK 3

References

(Earliest) J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
(Latest) J:194236 Dolan BM, et al., Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5671-6
All references(53)

Other accession IDs

MGD-MRK-33717, MGI:106033