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Pak3 Gene Detail
Summary
  • Symbol
    Pak3
  • Name
    p21 (RAC1) activated kinase 3
  • Synonyms
    PAK-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339656
    NCBI Gene: 18481
  • Gene Overview
    MyGene.info: PAK3
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:143518591-143797796 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 64.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    956 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339656
protein coding gene ChrX:143518371-143797796 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036155
protein coding gene ChrX:141072232-141361859 (+)
A/J MGP_AJ_G0036132
protein coding gene ChrX:140412113-140687644 (+)
AKR/J MGP_AKRJ_G0036058
protein coding gene ChrX:144956789-145245114 (+)
BALB/cJ MGP_BALBcJ_G0036123
protein coding gene ChrX:138635016-138921504 (+)
C3H/HeJ MGP_C3HHeJ_G0035831
protein coding gene ChrX:141150435-141435508 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036646
protein coding gene ChrX:145014220-145308036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033470
protein coding gene ChrX:131934602-132215545 (+)
CAST/EiJ MGP_CASTEiJ_G0035122
protein coding gene ChrX:121845616-122131762 (+)
CBA/J MGP_CBAJ_G0035808
protein coding gene ChrX:149593814-149877803 (+)
DBA/2J MGP_DBA2J_G0035966
protein coding gene ChrX:139507947-139783897 (+)
FVB/NJ MGP_FVBNJ_G0035900
protein coding gene ChrX:138704430-138979141 (+)
LP/J MGP_LPJ_G0036057
protein coding gene ChrX:142019596-142304389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035936
protein coding gene ChrX:157273817-157588050 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036683
protein coding gene ChrX:140383002-140657539 (+)
PWK/PhJ MGP_PWKPhJ_G0034816
protein coding gene ChrX:118647512-118927589 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034641
protein coding gene ChrX:122383372-122677605 (+)
WSB/EiJ MGP_WSBEiJ_G0035257
protein coding gene ChrX:138729328-139018517 (+)



Homology
more
  • Human Ortholog
    PAK3, p21 (RAC1) activated kinase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PAK3, p21 (RAC1) activated kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARA, beta-PAK, bPAK, MRX30, MRX47, OPHN3, PAK-3, PAK3beta
  • Links
    NCBI Gene ID: 5063
    neXtProt AC: NX_O75914
    UniProt: O75914

  • Chr Location
    Xq23; chrX:110944241-111227361 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PAK3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele display a selective impairment in hippocampal late-phase long-term potentiation, and deficits in learning and memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031284 Ensembl Gene Model | MGI Sequence Detail 279206 C57BL/6J ±  kb
transcript ENSMUST00000033640 Ensembl | MGI Sequence Detail 8348 Not Applicable  
polypeptide ENSMUSP00000033640 Ensembl | MGI Sequence Detail 559 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 1
    cDNA 12

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33717, MGI:106033
References
more
  • Summaries
    All 62
    Developmental Gene Expression 17
    Gene Ontology 13
    Phenotypes 12
  • Earliest
    J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
  • Latest
    J:239194 Jaudon F, et al., The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Mol Biol Cell. 2015 Jun 01;26(11):2112-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory