Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PAK2
  • Mouse genes Pak2
  • Rat genes Pak2
  • Zfish genes pak2a,pak2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pak2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PAK2	HDA		Human	PMID:25468996
Molecular Function	GO:0042802	identical protein binding	PAK2	IPI	UniProtKB:Q13177	Human	PMID:16837009
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P03406	Human	PMID:10607567
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:O60504	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:O94875	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P08631	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P12931	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P16333	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P62993	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q14155	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q15052	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q8TEJ3	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q9BX66	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:O55043	Human	PMID:16527308
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q14155	Human	PMID:16787945
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P04049	Human	PMID:16837009
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P53667	Human	PMID:16837009
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q14160	Human	PMID:18716323
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P42858	Human	PMID:19240112
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P63000	Human	PMID:19264842
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q5PP90	Human	PMID:19435845
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P63000	Human	PMID:20696164
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P60953	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P63000	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:O60504	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P55210	Human	PMID:21555521
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P63000	Human	PMID:22705156
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:O60504	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P60953	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q9H4E5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:O43639	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:O43639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P16333	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P60953	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q15052	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q9H4E5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:Q9NYB9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P60953	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PAK2	IPI	UniProtKB:P63000	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Pak2	IPI	UniProtKB:Q80U72	Mouse	MGI:MGI:3812202|PMID:18716323
Molecular Function	GO:0005515	protein binding	Pak2	IPI	UniProtKB:P42859	Mouse	MGI:MGI:3836371|PMID:19240112
Molecular Function	GO:0004672	protein kinase activity	Pak2	IDA		Mouse	PMID:23509247
Molecular Function	GO:0019901	protein kinase binding	PAK2	IPI	UniProtKB:P00519	Human	PMID:11121037
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK2	IDA		Human	PMID:11121037
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK2	EXP		Human	PMID:11278486
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK2	IDA		Human	PMID:11805089
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK2	EXP		Human	PMID:17060906
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK2	IDA		Human	PMID:21555521
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK2	IDA		Human	PMID:27889207
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK2	IMP		Human	PMID:33693784
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pak2	IDA		Mouse	PMID:28408623
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	PAK2	IDA		Human	PMID:11121037
Molecular Function	GO:0031267	small GTPase binding	PAK2	IPI	UniProtKB:P60953	Human	PMID:8625410
Molecular Function	GO:0031267	small GTPase binding	PAK2	IPI	UniProtKB:P63000	Human	PMID:8625410
Cellular Component	GO:0005911	cell-cell junction	PAK2	IMP		Human	PMID:25753039
Cellular Component	GO:0005737	cytoplasm	PAK2	IDA		Human	PMID:21555521
Cellular Component	GO:0005737	cytoplasm	PAK2	IDA		Human	PMID:25468996
Cellular Component	GO:0005829	cytosol	PAK2	IDA		Human	PMID:8625410
Cellular Component	GO:0098978	glutamatergic synapse	Pak2	IDA		Mouse	PMID:15182717
Cellular Component	GO:0098978	glutamatergic synapse	Pak2	IEP		Mouse	PMID:15182717
Cellular Component	GO:0005634	nucleus	PAK2	IDA		Human	PMID:21555521
Cellular Component	GO:0014069	postsynaptic density	Pak2	IDA		Mouse	PMID:15182717
Cellular Component	GO:0014069	postsynaptic density	Pak2	IEP		Mouse	PMID:15182717
Cellular Component	GO:0030141	secretory granule	Pak2	IDA		Rat	PMID:11943200|RGD:9835039
Biological Process	GO:0034333	adherens junction assembly	PAK2	IMP		Human	PMID:25753039
Biological Process	GO:0070830	bicellular tight junction assembly	PAK2	IMP		Human	PMID:25753039
Biological Process	GO:0001568	blood vessel development	pak2a	IGI	ZFIN:ZDB-GENO-071121-3,ZFIN:ZDB-MRPHLNO-071121-2	Zfish	PMID:17715297
Biological Process	GO:0001568	blood vessel development	pak2a	IMP	ZFIN:ZDB-GENO-071121-1	Zfish	PMID:17715297
Biological Process	GO:0001568	blood vessel development	pak2a	IMP	ZFIN:ZDB-MRPHLNO-071121-1	Zfish	PMID:17715297
Biological Process	GO:0001568	blood vessel development	pak2a	IMP	ZFIN:ZDB-MRPHLNO-071213-4,ZFIN:ZDB-MRPHLNO-071213-5	Zfish	PMID:17573532
Biological Process	GO:0001568	blood vessel development	pak2b	IGI	ZFIN:ZDB-GENO-071121-3,ZFIN:ZDB-MRPHLNO-071121-2	Zfish	PMID:17715297
Biological Process	GO:0003300	cardiac muscle hypertrophy	Pak2	IEP		Rat	PMID:22564263|RGD:9835036
Biological Process	GO:0071407	cellular response to organic cyclic compound	Pak2	IDA		Mouse	PMID:23509247
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Pak2	IEP		Rat	PMID:15629889|RGD:8693572
Biological Process	GO:0060996	dendritic spine development	Pak2	IGI	MGI:MGI:95564	Mouse	PMID:23509247
Biological Process	GO:0051179	localization	PAK2	IMP		Human	PMID:31391252
Biological Process	GO:0043066	negative regulation of apoptotic process	PAK2	IDA		Human	PMID:21555521
Biological Process	GO:0043066	negative regulation of apoptotic process	PAK2	IMP		Human	PMID:21555521
Biological Process	GO:0043066	negative regulation of apoptotic process	PAK2	IDA		Human	PMID:27889207
Biological Process	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	PAK2	IDA		Human	PMID:21555521
Biological Process	GO:0051497	negative regulation of stress fiber assembly	PAK2	IMP		Human	PMID:25753039
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PAK2	IDA		Human	PMID:11121037
Biological Process	GO:0016310	phosphorylation	PAK2	IDA		Human	PMID:21555521
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PAK2	IMP		Human	PMID:19240112
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PAK2	IDA		Human	PMID:11121037
Biological Process	GO:0046777	protein autophosphorylation	PAK2	IDA		Human	PMID:11805089
Biological Process	GO:0150105	protein localization to cell-cell junction	PAK2	IMP	UniProtKB:P10916|UniProtKB:P18206|UniProtKB:Q9UKX2	Human	PMID:25753039
Biological Process	GO:0006468	protein phosphorylation	PAK2	IDA		Human	PMID:11805089
Biological Process	GO:0051493	regulation of cytoskeleton organization	PAK2	IMP		Human	PMID:25753039

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern