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Pak2
Gene Detail
Symbol

Name
ID
Pak2
p21 protein (Cdc42/Rac)-activated kinase 2
MGI:1339984
Synonyms
5330420P17Rik, A130002K10Rik, D16Ertd269e, PAK-2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
22.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:32016290-32079342 bp, - strand
From VEGA annotation of GRCm38

  63053 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PAK2
Gene Tree: Pak2

Human
homologs
PAK2, p21 protein (Cdc42/Rac)-activated kinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5062
neXtProt AC: NX_Q13177

Human Synonyms: PAK65, PAKgamma

Human Chr (Location): 3q29; chr3:196739857-196832647 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(68) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit lethality between E8 and the postnatal period with prominent head folds, impaired somite development, and growth retardation. Mice homozygous for a knock-in allele exhibit increased cell proliferation and decreased apoptosis.
 
Interactions
Pak2 interacts with 398 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process actin cytoskeleton organization, activation of protein kinase activity, ...
Component cytoplasm, membrane, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (42)    Tissues (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
Western blot 18
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pak2 ; ZFIN pak2a, pak2b    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000023944 (Evidence)
Ensembl Gene Model ENSMUSG00000022781 (Evidence)
Entrez Gene 224105 (Evidence)
DFCI TC1617710, TC1615755, TC1574202, TC1625274
DoTS DT.110736557, DT.101381799, DT.101366193, DT.110736582, DT.536407
NIA Mouse Gene Index U036972
EC 2.7.11.1
Consensus CDS Project CCDS28112.1
International Mouse Phenotyping Consortium Status Pak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023944 VEGA Gene Model | MGI Sequence Detail 63053 C57BL/6J ±  kb
transcript OTTMUST00000058513 VEGA | MGI Sequence Detail 5741 Not Applicable 
polypeptide OTTMUSP00000028355 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016253 Integrin-linked protein kinase
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012241 serine/threonine-protein kinase PAK 2
References
(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:213213 Phee H, et al., Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife. 2014;3:e02270
All references(68)
Other
accession IDs
MGI:1098647, MGI:1924351, MGI:2146488, MGI:2442429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory