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Pak2 Gene Detail
Summary
  • Symbol
    Pak2
  • Name
    p21 protein (Cdc42/Rac)-activated kinase 2
  • Synonyms
    5330420P17Rik, A130002K10Rik, D16Ertd269e, PAK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339984
    NCBI Gene: 224105
  • Gene Overview
    MyGene.info: PAK2
Location & Maps
more
  • Sequence Map
    Chr16:32016290-32079342 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63053 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 22.40 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PAK2, p21 (RAC1) activated kinase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PAK2, p21 (RAC1) activated kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAK65, PAKgamma
  • Links
    NCBI Gene ID: 5062
    neXtProt AC: NX_Q13177

  • Chr Location
    3q29; chr3:196739857-196832647 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 99711
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PAK2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 4 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality between E8 and the postnatal period with prominent head folds, impaired somite development, and growth retardation. Mice homozygous for a knock-in allele exhibit increased cell proliferation and decreased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023944 VEGA Gene Model | MGI Sequence Detail 63053 C57BL/6J ±  kb
transcript OTTMUST00000058513 VEGA | MGI Sequence Detail 5741 Not Applicable  
polypeptide OTTMUSP00000028355 VEGA | MGI Sequence Detail 524 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    248 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGI:1098647, MGI:1924351, MGI:2146488, MGI:2442429
References
more
  • Summaries
    All 69
    Developmental Gene Expression 13
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
  • Latest
    J:233013 Reddy PN, et al., p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with beta-Pix. Blood. 2016 Apr 21;127(16):1967-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory