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Pak2 Gene Detail
Summary
  • Symbol
    Pak2
  • Name
    p21 (RAC1) activated kinase 2
  • Synonyms
    5330420P17Rik, A130002K10Rik, D16Ertd269e, PAK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339984
    NCBI Gene: 224105
  • Gene Overview
    MyGene.info: PAK2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32016290-32079342 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 22.40 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339984
protein coding gene Chr16:32016290-32079342 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022727
protein coding gene Chr16:30033904-30105041 (-)
A/J MGP_AJ_G0022692
protein coding gene Chr16:28646396-28709723 (-)
AKR/J MGP_AKRJ_G0022665
protein coding gene Chr16:29688221-29752500 (-)
BALB/cJ MGP_BALBcJ_G0022694
protein coding gene Chr16:28797672-28860870 (-)
C3H/HeJ MGP_C3HHeJ_G0022459
protein coding gene Chr16:29808964-29875751 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023143
protein coding gene Chr16:30685678-30755021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020661
protein coding gene Chr16:29014882-29080968 (-)
CAST/EiJ MGP_CASTEiJ_G0021987
protein coding gene Chr16:29941762-30005912 (-)
CBA/J MGP_CBAJ_G0022429
protein coding gene Chr16:31938260-32013305 (-)
DBA/2J MGP_DBA2J_G0022562
protein coding gene Chr16:28496837-28561726 (-)
FVB/NJ MGP_FVBNJ_G0022537
protein coding gene Chr16:28481507-28545471 (-)
LP/J MGP_LPJ_G0022629
protein coding gene Chr16:29815853-29889000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022556
protein coding gene Chr16:31401231-31466739 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023155
protein coding gene Chr16:29665729-29729836 (-)
PWK/PhJ MGP_PWKPhJ_G0021726
protein coding gene Chr16:28814980-28853625 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021557
protein coding gene Chr16:29443648-29516290 (-)
WSB/EiJ MGP_WSBEiJ_G0022031
protein coding gene Chr16:29602759-29669486 (-)



Homology
more
  • Human Ortholog
    PAK2, p21 (RAC1) activated kinase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PAK2, p21 (RAC1) activated kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAK65, PAKgamma
  • Links
    NCBI Gene ID: 5062
    neXtProt AC: NX_Q13177
    UniProt: Q13177

  • Chr Location
    3q29; chr3:196739857-196832647 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 99711
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PAK2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 3 genetic backgrounds
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality between E8 and the postnatal period with prominent head folds, impaired somite development, and growth retardation. Mice homozygous for a knock-in allele exhibit increased cell proliferation and decreased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224105 NCBI Gene Model | MGI Sequence Detail 63053 C57BL/6J ±  kb
    transcript NM_177326 RefSeq | MGI Sequence Detail 5741 C57BL/6  
    polypeptide Q8CIN4 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1098647, MGI:1924351, MGI:2146488, MGI:2442429
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
    • Latest
      J:243667 Chang JK, et al., Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization. J Biol Chem. 2017 Jun 09;292(23):9523-9539

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory