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Pak2
Gene Detail
 Symbol
Name
ID
Pak2
p21 protein (Cdc42/Rac)-activated kinase 2
MGI:1339984
Synonyms 5330420P17Rik, A130002K10Rik, D16Ertd269e, PAK-2
Feature Type protein coding gene
Genetic Map
Chromosome 16
22.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:32016290-32079342 bp, - strand
From VEGA annotation of GRCm38

  63053 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Pak2

Human
homologs
Human Homolog PAK2, p21 protein (Cdc42/Rac)-activated kinase 2
NCBI Gene ID 5062
neXtProt AC  NX_Q13177
Human Synonyms  PAK65, PAKgamma
Human Chr (Location)  3q29; chr3:196739857-196832647 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(68) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit lethality between E8 and the postnatal period with prominent head folds, impaired somite development, and growth retardation. Mice homozygous for a knock-in allele exhibit increased cell proliferation and decreased apoptosis.
 
Interactions
Pak2 interacts with 399 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process apoptotic process, cytokinesis, ...
Component cytoplasm, membrane, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (42)    Tissues (24)   
Theiler Stages: 15, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 24
Western blot 18
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000023944 (Evidence)
Ensembl Gene ModelENSMUSG00000022781 (Evidence)
Entrez Gene224105 (Evidence)
DFCITC1574202, TC1615755, TC1617710, TC1625274
DoTSDT.101366193, DT.101381799, DT.110736557, DT.110736582, DT.536407
NIA Mouse Gene IndexU036972
EC2.7.11.1
Consensus CDS ProjectCCDS28112.1
International Mouse Knockout Project StatusPak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023944 VEGA Gene Model | MGI Sequence Detail 63053 C57BL/6J ±  kb
transcript OTTMUST00000058513 VEGA | MGI Sequence Detail 5741 Not Applicable 
polypeptide OTTMUSP00000028355 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012241 serine/threonine-protein kinase PAK 2
References (Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:195865 Dorrance AM, et al., The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 2013 Mar 28;121(13):2474-82
All references(68)
Other
accession IDs
MGI:1098647, MGI:1924351, MGI:2146488, MGI:2442429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory