Pak2
Gene Detail

Symbol Name ID

Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 MGI:1339984

Synonyms

5330420P17Rik, A130002K10Rik, D16Ertd269e, PAK-2

Feature Type

protein coding gene

Genetic Map

Chromosome 16

22.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:32016290-32079342 bp, - strand From VEGA annotation of GRCm38   63053 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:99711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pak2

Human homologs

Human Homolog		PAK2, p21 protein (Cdc42/Rac)-activated kinase 2
NCBI Gene ID		5062
neXtProt AC		NX_Q13177
Human Synonyms		PAK65, PAKgamma
Human Chr (Location)		3q29; chr3:196466728-196559518 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(73) : Targeted(5) Gene trapped(68)
 

Mice homozygous for a knock-out allele exhibit lethality between E8 and the postnatal period with prominent head folds, impaired somite development, and growth retardation. Mice homozygous for a knock-in allele exhibit increased cell proliferation and decreased apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	apoptotic process, metabolic process, ...
Component	cytoplasm, membrane, ...
Function	ATP binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (42)    Tissues (24)   
Theiler Stages: 15, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	24
Western blot	18

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000023944 (Evidence)
Ensembl Gene Model	ENSMUSG00000022781 (Evidence)
Entrez Gene	224105 (Evidence)
DFCI	TC1574202, TC1615755, TC1617710, TC1625274
DoTS	DT.536407, DT.101366193, DT.101381799, DT.110736557, DT.110736582
NIA Mouse Gene Index	U036972
EC	2.7.11.1
Consensus CDS Project	CCDS28112.1
International Mouse Knockout Project Status	Pak2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023944	VEGA Gene Model | MGI Sequence Detail	63053	C57BL/6J
transcript	OTTMUST00000058513	VEGA | MGI Sequence Detail	5741	Not Applicable
polypeptide	OTTMUSP00000028355	VEGA | MGI Sequence Detail	524	Not Applicable

All sequences(48) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(178 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000095	PAK-box/P21-Rho-binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000012241	serine/threonine-protein kinase PAK 2

References

(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:194236 Dolan BM, et al., Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5671-6
All references(65)

Other accession IDs

MGI:1098647, MGI:1924351, MGI:2146488, MGI:2442429