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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Pak2
p21 (RAC1) activated kinase 2
MGI:1339984
25 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Pak2em1(IMPC)H/Pak2+
C57BL/6NTac-Pak2em1(IMPC)H/H
increased circulating amylase level J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular volume J:211773
prolonged RR interval J:211773
Pak2em1(IMPC)H/Pak2em1(IMPC)H
C57BL/6NTac-Pak2em1(IMPC)H/H
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Pak2Gt(OST104058)Lex/Pak2+
B6;129S5-Pak2Gt(OST104058)Lex/J
abnormal actin cytoskeleton morphology J:271067
abnormal excitatory postsynaptic potential J:271067
abnormal neuronal migration J:271067
abnormal postsynaptic density morphology J:271067
abnormal response to social novelty J:271067
abnormal social investigation J:271067
normal behavior/neurological phenotype J:271067
decreased dendritic spine density J:271067
increased grooming behavior J:271067
increased stereotypic behavior J:271067
reduced long-term potentiation J:271067
social withdrawal J:271067
Pak2tm1.1Cher/Pak2tm1.1Cher
Not Specified
abnormal hematopoietic stem cell physiology J:195865
Pak2tm1.1Rjak/Pak2tm1.1Rjak
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cell death J:171914
increased fibroblast proliferation J:171914
Pak2tm1Dgen/Pak2tm1Dgen
involves: 129P2/OlaHsd * C57BL/6J
preweaning lethality, complete penetrance J:82809
Pak2tm1Rjak/Pak2tm1Rjak
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
decreased embryo size J:171914
embryonic growth retardation J:171914
impaired somite development J:171914
open neural tube J:171914
preweaning lethality, complete penetrance J:171914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory