Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OPRK1
  • Mouse genes Oprk1
  • Rat genes Oprk1
  • Zfish genes oprk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Oprk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038048	dynorphin receptor activity	OPRK1	IMP		Human	PMID:7624359
Molecular Function	GO:0038048	dynorphin receptor activity	OPRK1	IDA		Human	PMID:8755601
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	OPRK1	IDA		Human	PMID:22437504
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	Oprk1	IDA		Mouse	MGI:MGI:1197118|PMID:9463367
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	Oprk1	IMP		Mouse	PMID:26635353
Molecular Function	GO:0042277	peptide binding	oprk1	IDA		Zfish	PMID:16842913
Molecular Function	GO:0005515	protein binding	OPRK1	IPI	UniProtKB:Q9H0R8	Human	PMID:16431922
Molecular Function	GO:0005515	protein binding	OPRK1	IPI	UniProtKB:P35414	Human	PMID:22200678
Molecular Function	GO:0005515	protein binding	OPRK1	IPI	UniProtKB:Q16617	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Oprk1	IPI	RGD:3234	Rat	PMID:21041644|RGD:9831449
Molecular Function	GO:0033612	receptor serine/threonine kinase binding	Oprk1	IPI	RGD:2062	Rat	PMID:27865836|RGD:13513990
Cellular Component	GO:0043679	axon terminus	Oprk1	IDA		Rat	PMID:17120286|RGD:9831429
Cellular Component	GO:0005829	cytosol	OPRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Oprk1	IDA		Rat	PMID:17120286|RGD:9831429
Cellular Component	GO:0016020	membrane	OPRK1	IDA		Human	PMID:22437504
Cellular Component	GO:0043025	neuronal cell body	Oprk1	IDA		Rat	PMID:17120286|RGD:9831429
Cellular Component	GO:0005654	nucleoplasm	OPRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043204	perikaryon	Oprk1	IDA		Rat	PMID:17120286|RGD:9831429
Cellular Component	GO:0005886	plasma membrane	OPRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	OPRK1	IMP		Human	PMID:7624359
Cellular Component	GO:0005886	plasma membrane	Oprk1	IDA		Mouse	MGI:MGI:1197118|PMID:9463367
Cellular Component	GO:0005886	plasma membrane	Oprk1	IDA		Rat	PMID:17120286|RGD:9831429
Cellular Component	GO:0045211	postsynaptic membrane	Oprk1	IDA		Rat	PMID:11746715|RGD:13702363
Cellular Component	GO:0042734	presynaptic membrane	Oprk1	IDA		Rat	PMID:11746715|RGD:13702363
Cellular Component	GO:0045202	synapse	Oprk1	IDA		Rat	PMID:17120286|RGD:9831429
Cellular Component	GO:0030672	synaptic vesicle membrane	Oprk1	IDA		Rat	PMID:11746715|RGD:13702363
Biological Process	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	OPRK1	IDA		Human	PMID:22437504
Biological Process	GO:0048148	behavioral response to cocaine	Oprk1	IMP		Rat	PMID:24919534|RGD:9831434
Biological Process	GO:0071333	cellular response to glucose stimulus	Oprk1	IDA		Rat	PMID:27865836|RGD:13513990
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Oprk1	IEP		Rat	PMID:9645969|RGD:9831421
Biological Process	GO:1990708	conditioned place preference	Oprk1	IMP		Rat	PMID:21549821|RGD:9831443
Biological Process	GO:0051607	defense response to virus	OPRK1	IDA		Human	PMID:8755601
Biological Process	GO:0042755	eating behavior	Oprk1	IMP		Rat	PMID:11961051|RGD:9831406
Biological Process	GO:0044849	estrous cycle	Oprk1	IEP		Rat	PMID:21041644|RGD:9831449
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	OPRK1	IDA		Human	PMID:8755601
Biological Process	GO:0006955	immune response	OPRK1	IDA		Human	PMID:8755601
Biological Process	GO:0007626	locomotory behavior	Oprk1	IMP		Mouse	MGI:MGI:1197118|PMID:9463367
Biological Process	GO:0042711	maternal behavior	Oprk1	IDA		Rat	PMID:22641418|RGD:9831394
Biological Process	GO:0033685	negative regulation of luteinizing hormone secretion	Oprk1	IMP		Rat	PMID:23391862|RGD:9831393
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Oprk1	IDA		Rat	PMID:9572309|RGD:8553369
Biological Process	GO:0033603	positive regulation of dopamine secretion	Oprk1	IDA		Rat	PMID:17568430|RGD:9831445
Biological Process	GO:1904000	positive regulation of eating behavior	Oprk1	IMP		Rat	PMID:17456590|RGD:9831437
Biological Process	GO:0040017	positive regulation of locomotion	Oprk1	IDA		Rat	PMID:17568430|RGD:9831445
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	Oprk1	IDA		Rat	PMID:16648139|RGD:9831415
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	Oprk1	IDA		Rat	PMID:12815037|RGD:9831413
Biological Process	GO:0046877	regulation of saliva secretion	Oprk1	IMP		Mouse	MGI:MGI:1197118|PMID:9463367
Biological Process	GO:0051930	regulation of sensory perception of pain	Oprk1	IMP		Rat	PMID:10908631|RGD:9831416
Biological Process	GO:1903937	response to acrylamide	Oprk1	IEP		Rat	PMID:22197712|RGD:9831396
Biological Process	GO:0042220	response to cocaine	Oprk1	IEP		Rat	PMID:10554970|RGD:9831419
Biological Process	GO:0042220	response to cocaine	Oprk1	IEP		Rat	PMID:9645969|RGD:9831421
Biological Process	GO:0043627	response to estrogen	Oprk1	IEP		Rat	PMID:8904783|RGD:9831422
Biological Process	GO:0045471	response to ethanol	Oprk1	IEP		Rat	PMID:10554970|RGD:9831419
Biological Process	GO:0045471	response to ethanol	Oprk1	IEP		Rat	PMID:9645969|RGD:9831421
Biological Process	GO:0032868	response to insulin	Oprk1	IDA		Rat	PMID:10995763|RGD:9831420
Biological Process	GO:0032868	response to insulin	Oprk1	IEP		Rat	PMID:9645969|RGD:9831421
Biological Process	GO:0043278	response to morphine	Oprk1	IEP		Rat	PMID:16753266|RGD:9831397
Biological Process	GO:0009314	response to radiation	Oprk1	IEP		Rat	PMID:22337865|RGD:9831403
Biological Process	GO:0019233	sensory perception of pain	Oprk1	IMP		Mouse	MGI:MGI:1197118|PMID:9463367
Biological Process	GO:0050951	sensory perception of temperature stimulus	Oprk1	IMP		Rat	PMID:21041644|RGD:9831449

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern