Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPY
  • Mouse genes Npy
  • Rat genes Npy
  • Zfish genes npy
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npy

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	Npy	IGI	MGI:MGI:104963	Mouse	PMID:9623984
Molecular Function	GO:0001664	G protein-coupled receptor binding	Npy	IDA		Mouse	PMID:10698177
Molecular Function	GO:0031841	neuropeptide Y receptor binding	Npy	IMP		Rat	PMID:12446577|RGD:628420
Molecular Function	GO:0031841	neuropeptide Y receptor binding	npy	IDA		Zfish	PMID:23508731
Molecular Function	GO:0005515	protein binding	NPY	IPI	UniProtKB:F1D8P7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NPY	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	npy	IPI	ZFIN:ZDB-GENE-040924-8	Zfish	PMID:16257457
Molecular Function	GO:0031843	type 2 neuropeptide Y receptor binding	npy	IPI	UniProtKB:Q1ACB0	Zfish	PMID:16359756
Molecular Function	GO:0031843	type 2 neuropeptide Y receptor binding	npy	IPI	UniProtKB:Q1ACB1	Zfish	PMID:16359756
Molecular Function	GO:0031843	type 2 neuropeptide Y receptor binding	npy	IDA		Zfish	PMID:16257457
Cellular Component	GO:0005737	cytoplasm	Npy	IDA		Mouse	PMID:24582971
Cellular Component	GO:0005615	extracellular space	Npy	IDA		Rat	PMID:17353067|RGD:10448941
Cellular Component	GO:0005615	extracellular space	Npy	IDA		Rat	PMID:9590691|RGD:8554847
Cellular Component	GO:0098982	GABA-ergic synapse	Npy	EXP		Mouse	PMID:22190627
Cellular Component	GO:0098982	GABA-ergic synapse	Npy	IDA		Mouse	PMID:22190627
Cellular Component	GO:0005794	Golgi apparatus	NPY	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043005	neuron projection	Npy	IDA		Rat	PMID:17353067|RGD:10448941
Cellular Component	GO:0098992	neuronal dense core vesicle	Npy	IDA		Rat	PMID:29775703|RGD:155230710
Cellular Component	GO:0098992	neuronal dense core vesicle	Npy	IDA		Rat	PMID:29166604|RGD:15023486
Cellular Component	GO:0098992	neuronal dense core vesicle	Npy	IDA		Rat	PMID:30021165|RGD:14995321
Cellular Component	GO:0043204	perikaryon	Npy	IDA		Rat	PMID:21344400|RGD:10448936
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Npy	IDA		Rat	PMID:17353067|RGD:10448941
Cellular Component	GO:0043195	terminal bouton	Npy	IDA		Rat	PMID:21344400|RGD:10448936
Biological Process	GO:0008343	adult feeding behavior	Npy	IDA		Rat	PMID:9590691|RGD:8554847
Biological Process	GO:0007568	aging	Npy	IEP		Rat	PMID:21595512|RGD:10448272
Biological Process	GO:0021954	central nervous system neuron development	NPY	IEP		Human	PMID:20846339
Biological Process	GO:0021987	cerebral cortex development	NPY	IEP		Human	PMID:9067840
Biological Process	GO:0007268	chemical synaptic transmission	Npy	IDA		Rat	PMID:12482942|RGD:628512
Biological Process	GO:0042117	monocyte activation	Npy	IDA		Rat	PMID:15342191|RGD:1580787
Biological Process	GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	Npy	IDA		Rat	PMID:18805447|RGD:10448932
Biological Process	GO:0071878	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	npy	IMP	ZFIN:ZDB-GENO-180625-3	Zfish	PMID:29225025
Biological Process	GO:0045776	negative regulation of blood pressure	Npy	IMP		Rat	PMID:15699473|RGD:1357410
Biological Process	GO:1901215	negative regulation of neuron death	Npy	IDA		Rat	PMID:22860197|RGD:10448933
Biological Process	GO:0031175	neuron projection development	NPY	IEP		Human	PMID:20846339
Biological Process	GO:0007218	neuropeptide signaling pathway	Npy	IMP		Rat	PMID:15703301|RGD:1580180
Biological Process	GO:0007218	neuropeptide signaling pathway	Npy	IMP		Rat	PMID:16040808|RGD:1580181
Biological Process	GO:0032100	positive regulation of appetite	Npy	IDA		Rat	PMID:9590691|RGD:8554847
Biological Process	GO:0008284	positive regulation of cell population proliferation	Npy	IDA		Rat	PMID:21595512|RGD:10448272
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Npy	IDA		Rat	PMID:15342191|RGD:1580787
Biological Process	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	npy	IMP	ZFIN:ZDB-GENO-180625-3	Zfish	PMID:29225025
Biological Process	GO:0045964	positive regulation of dopamine metabolic process	Npy	IDA		Rat	PMID:19579268|RGD:10448966
Biological Process	GO:1904000	positive regulation of eating behavior	Npy	IDA		Rat	PMID:21303672|RGD:10448958
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Npy	IDA		Rat	PMID:21595512|RGD:10448272
Biological Process	GO:2000253	positive regulation of feeding behavior	npy	IMP	ZFIN:ZDB-MRPHLNO-130312-6	Zfish	PMID:23300705
Biological Process	GO:1904407	positive regulation of nitric oxide metabolic process	Npy	IDA		Rat	PMID:18805447|RGD:10448932
Biological Process	GO:0008217	regulation of blood pressure	Npy	IDA		Mouse	PMID:9623984
Biological Process	GO:0032903	regulation of nerve growth factor production	Npy	IDA		Rat	PMID:22860197|RGD:10448933
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	Npy	EXP		Rat	PMID:16026936|RGD:155230755
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	Npy	IDA		Rat	PMID:16026936|RGD:155230755
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Npy	EXP		Rat	PMID:16026936|RGD:155230755
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Npy	IDA		Rat	PMID:16026936|RGD:155230755
Biological Process	GO:0050909	sensory perception of taste	Npy	IEP		Rat	PMID:16040808|RGD:1580181
Biological Process	GO:0048572	short-day photoperiodism	Npy	IEP		Rat	PMID:19490367|RGD:6480663
Biological Process	GO:0099538	synaptic signaling via neuropeptide	Npy	IDA		Mouse	PMID:22190627
Biological Process	GO:0099538	synaptic signaling via neuropeptide	Npy	EXP		Mouse	PMID:22190627

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern